ER exit pathways and the control of proteostasis:Crucial role of the UPR,COPII,and ER-phagy in the secretory pathway  

作　　者：GIUSEPPINA AMODIO VALENTINA PAGLIARA PAOLO REMONDELLI ORNELLA MOLTEDO 

机构地区：[1]Dipartimento di Medicina,Chirurgia e Odontoiatria“Scuola Medica Salernitana”,Universitàdegli Studi di Salerno,Baronissi,84034,Italy,2 Dipartimento di Farmacia,Universitàdegli Studi di Salerno,Fisciano,84084,Italy

出　　处：《BIOCELL》2022年第5期1131-1137,共7页生物细胞（英文）

基　　金：This work was supported by POR FERS Regione Campania 2014–2020 ASSE 1 O.S 1.2;grant System Innovation for Cancer Early Diagnosis(SICED).

摘　　要：The endoplasmic reticulum(ER)is the site of entry of all proteins that function in the secretory pathway including the extracellular environment.Because it controls the folding of newly synthesized secretory proteins,the ER is indispensable for the maintenance of proteostasis in the secretory pathway.Within the ER and,in part,in post-ER compartments,the quality control of protein folding is under the regulation of the unfolded protein response(UPR)pathways.The UPR strategy is to enhance protein folding,increase the ER degradation pathway of misfolded proteins,and allow the exit from the ER of only correctly folded proteins.The latter is controlled by the multimeric complex COPII,which also provides some of the components for ER-phagy the only route for the disposal of protein aggregates.In this overview,we wish to contribute to the introduction of new perspectives in the study of the mechanisms underlying the control of proteostasis within the secretory pathway.

关 键 词：PROTEOSTASIS ER stress Unfolded protein response COPII ER-phagy 

分 类 号：Q26[生物学—细胞生物学]