ERGIC

作品数：25被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：刘磊谢印良邵晓枫许元富方理本更多>>
相关机构：清华大学北京协和医学院中国医学科学院北京协和医学院浙江大学更多>>
相关期刊：《天津医药》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金北京市自然科学基金广东省自然科学基金天津市自然科学基金更多>>
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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion
《Neural Regeneration Research》2025年第10期2838-2854,共17页Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du 
supported by the National Natural Science Foundation of China,Nos.82374561(to JD),82174490(to JF);the Medical and Health Science and Technology Program of Zhejiang Province,No.2021RC098(to JD);the Research Project of Zhejiang Chinese Medical University,Nos.2022JKZKTS44(to JD),2022FSYYZZ07(to JF).
Pain is often comorbid with emotional disorders such as anxiety and depression.Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairme...
关键词：anterior cingulate cortex ANXIETY chronic pain circuit communication COMORBIDITY depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission 
A spinal neural circuit for electroacupuncture that regulates gastric functional disorders
《Journal of Integrative Medicine》2025年第1期56-65,共10页Meng-ting Zhang Yi-feng Liang Qian Dai He-ren Gao Hao Wang Li Chen Shun Huang Xi-yang Wang Guo-ming Shen 
supported by the Anhui Province Scientific Research Planning Project(No.2023AH050851 and No.2022AH050438);National Natural Science Foundation of China(No.81904095,No.82205274 and No.82101483);Research Project of Xin’an Medical and Chinese Medicine Modernization Research Institute(No.2023CXMMTCM016);Anhui University of Chinese Medicine 2018–2019 High-level Talents Introduction Support Plan(No.2019rcyb002);Excellent Youth Project of Anhui Universities of China(No.2022AH030065).
Objective Acupuncture therapies are known for their effectiveness in treating a variety of gastric diseases,although the mechanisms underlying these effects are not fully understood.This study tested the effectiveness...
关键词：Acupuncture therapies Gastric motility disorder Spinalγ-aminobutyric acid-ergic neurons Sympathetic nerve ZHONGWAN WEISHU 
Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress
《World Journal of Psychiatry》2025年第2期209-221,共13页Si-Hai Chen Bo Lan Ying-Ying Zhang Guo-Hui Li Yu-Long Qian Ming-Xing Hu Yin-Lin Tian Wei-Dong Zang Jing Cao Guang-Hai Wang Yi-Gang Wang 
Supported by the Natural Science Foundation of Xiaogan,China,No.XGKJ2023010036.
BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,b...
关键词：Zona incerta Gamma-aminobutyric acid-ergic DEPRESSION ANXIETY Animal behavior studies Whole-cell patchclamp 
Intelligent cholinergic white matter pathways algorithm based on U-net reflects cognitive impairment in patients with silent cerebrovascular disease
《Stroke & Vascular Neurology》2024年第6期699-707,共9页Beini Fei Yu Cheng Ying Liu Guangzheng Zhang Anyan Ge Junyi Luo Shan Wu He Wang Jing Ding Xin Wang 
Shanghai Municipal Committee of Science and Technology(Code 20Z11900800).
Background and objective The injury of the cholinergic white matter pathway underlies cognition decline in patients with silent cerebrovascular disease(SCD)with white matter hyperintensities(WMH)of vascular origin.How...
关键词：CHOLINERGIC PATIENTS impairment 
Reconstitution of membrane contact by unilamellar vesicles
《Biophysics Reports》2023年第4期188-194,共7页Shulin Li Min Zhang Liang Ge 
funded by National Natural Science Foundation of China(32225013,32130023,9225430003,31872832);Ministry of Science and Technology of the People’s Republic of China(2021YFA0804802,2019YFA0508602);Beijing Natural Science Foundation(JQ20028);supported by Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University(2022Z82WKJ009)
Eukaryotic cells compartmentalize diverse biochemical functions within organelles defined by intracellular membranes.Recent focus has intensified on studying the interactions among organelles and the role of membrane ...
关键词：Membrane contacts Organelle interaction network Giant unilamellar vesicle(GUV) Liposome ER-Golgi intermediate compartment(ERGIC) ER-exit sites(ERES) COPII TMED9 SEC12 Autophagy AUTOPHAGOSOME 
Corrigendum to“Biogenesis of autophagosomes from the ERGIC membrane system”[Journal of Genetics and Genomics (2023) 50,3-6]
《Journal of Genetics and Genomics》2023年第4期293-293,共1页Yaping Han Shulin Li Liang Ge 
This corrigendum clarifies statement in the article"Biogenesis of autophagosomes from the ERGIC membrane system"by Han et al.(2023).In the"The role of ERGIC-equivalents and COPll vesicles in autophagy in yeast"section...
关键词：STATEMENT system REMOVE 
Biogenesis of autophagosomes from the ERGIC membrane system被引量：1
《Journal of Genetics and Genomics》2023年第1期3-6,共4页Yaping Han Shulin Li Liang Ge 
funded by Beijing Natural Science Foundation(JQ20028);the National Natural Science Foundation of China(32130023,91854114,32061143009);Ministry of Science and Technology of the People’s Republic of China(2019YFA0508602,2021YFA0804802)。
Introduction Macroautophagy(hereafter referred as autophagy)is a process of cellular self-degradation.In response to nutrient deprivation or other stimuli,a nascent double-membrane autophagosome,encapsulating intracel...
关键词：ERGIC COPII vesicle Autophagosome biogenesis Autophagy ERES 
The diverse role of the raphe 5-HTergic systems in epilepsy被引量：2
《Acta Pharmacologica Sinica》2022年第11期2777-2788,共12页He-ming Cheng Chen-shu Gao Qiu-wen Lou Zhong Chen Yi Wang 
the National Natural Science Foundation of China(81630098,82022071);the Starry Night Science Fund of the Zhejiang UniversityShanghai InstituteforAdvancedStudy(SN-ZJU-SIAS-0011).
The raphe nuclei comprise nearly all of 5-hydroxytryptaminergic(5-HTergic)neurons in the brain and are widely acknowledged to participate in the modulation of neural excitability.“Excitability-inhibition imbalance”r...
关键词：raphe nuclei 5-HT EPILEPSY epilepsy-associated comorbidities SSRI sudden unexpected death in epilepsy(SUDEP) 
Diverse cellular strategies for the export of leaderless proteins被引量：3
《National Science Open》2022年第3期10-25,共16页Jianfei Zheng Liang Ge 
supported by the National Natural Science Foundation of China(32130023,91854114,and 32061143009);the Ministry of Science and Technology of the People’s Republic of China(2019YFA0508602 and 2021YFA0804802);the Beijing Natural Science Foundation(JQ20028)。
Unconventional protein export/secretion(UPE/UPS),in contrast to the classical ER-Golgi-dependent export/secretion of proteins with a leader sequence(signal peptide),employs multiple means to release leaderless cargoes...
关键词：secretion unconventional protein secretion TRANSLOCATION ERGIC AUTOPHAGOSOME multi-vesicular body LYSOSOME vesicle transport FGF2 GSDMD IL-1 
A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis被引量：6
《Cell Research》2022年第2期119-138,共20页Shulin Li Rui Yan Jialu Xu Shiqun Zhao Xinyu Ma Qiming Sun Min Zhang Ying Li Jun-Jie Gogo Liu Liangyi Chen Sai Li Ke Xu Liang Ge 
The work is funded by National Key R&D Program of China(2019YFA0508602);the National Natural Science Foundation of China(91854114,32061143009,31872832,31872826);Beijing Natural Science Foundation(JQ20028);Tsinghua Independent Research Program(2019Z06QCX02);Tsinghua University COVID-19 Emergency Aid Fund(2020Z99CFZ024),and Tsinghua-Peking Center for Life Sciences.
Under stress,the endomembrane system undergoes reorganization to support autophagosome biogenesis,which is a central step in autophagy.How the endomembrane system remodels has been poorly understood.Here we identify a...
关键词：system stress GENESIS 
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