Diverse cellular strategies for the export of leaderless proteins  

作　　者：Jianfei Zheng Liang Ge 

机构地区：[1]The State Key Laboratory of Membrane Biology,Tsinghua University-Peking University Joint Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《National Science Open》2022年第3期10-25,共16页国家科学进展（英文）

基　　金：supported by the National Natural Science Foundation of China(32130023,91854114,and 32061143009);the Ministry of Science and Technology of the People’s Republic of China(2019YFA0508602 and 2021YFA0804802);the Beijing Natural Science Foundation(JQ20028)。

摘　　要：Unconventional protein export/secretion(UPE/UPS),in contrast to the classical ER-Golgi-dependent export/secretion of proteins with a leader sequence(signal peptide),employs multiple means to release leaderless cargoes(and in some special cases,cargoes with a leader sequence)to the extracellular space.By far,two major types of UPE have been classified,vesicle-independent UPE and vesicle-dependent UPE.In the former,UPE cargoes can directly translocate across the plasma membrane from the cytoplasm without the assistance of a vesicle carrier.In the latter,UPE cargoes translocate into the lumen of a vesicle which then delivers them out of the cell through membrane trafficking.Both types of UPE require multiple unconventional solutions to complete secretion.Here,we briefly discuss the multiple strategies for a UPE cargo release,focusing on two key steps of leaderless cargoes release in UPE:protein translocation and membrane trafficking.

关 键 词：secretion unconventional protein secretion TRANSLOCATION ERGIC AUTOPHAGOSOME multi-vesicular body LYSOSOME vesicle transport FGF2 GSDMD IL-1 

分 类 号：Q257[生物学—细胞生物学]