Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions  

作　　者：Tiantian Ma Feng Zhang Yaqing Wang Zhiheng Xu 

机构地区：[1]Center for Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Journal of Genetics and Genomics》2022年第6期519-522,共4页遗传学报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(91854118,31921002,31730108,32061143026);the major projects of the Ministry of Science and Technology(2021ZD0202300);Chinese Academy of Sciences(XDB32020100,YJKYYQ20200052)。

摘　　要：Coat protein complex Ⅱ(COPⅡ)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum(ER) to different destinations. c TAGE5/MEA6 is essential for the development and function of different organs. It regulates the assembly of COPⅡ carrier and cargo trafficking through direct or indirect interaction with COPII components. c TAGE5/MEA6 mainly coordinates with another scaffold protein, TANGO1, to play essential roles in the trafficking and secretion of both large and small cargoes in multiple organs. In this viewpoint, we would like to discuss the molecular mechanisms underlying c TAGE5/MEA6-mediated cargo transport and biological functions.

关 键 词：cTAGE5/MEA6 COPII ER Cargo secretion 

分 类 号：Q945[生物学—植物学]