A COPII subunit interacting with ER-phagy receptor:a new potential avenue to maintaining neuronal homeostasis  

作　　者：Shifang Huang Mingzhu Tang Honglu Jiang Yuting Li Haoliang Hu 

机构地区：[1]Department of Pharmacology,Yongzhou Vocational Technical College,Yongzhou 425000,China [2]Guangzhou Regenerative Medicine and Health Guangdong Laboratory,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,China [3]Department of Pharmacology,Yongzhou Radio and TV University,Yongzhou 425000,China

出　　处：《Acta Biochimica et Biophysica Sinica》2020年第6期698-700,共3页生物化学与生物物理学报（英文版）

基　　金：the grants from the Scientific Research Project of Education Department of Hunan Province,China(Nos.18C1748 and 19B578).

摘　　要：Endoplasmic reticulum(ER)-associated degradation(ERAD)plays an essential role in protein quality control in the ER.It acts through recognizing misfolded or unassembled proteins and retrotranslocating them across the ER membrane into the cytosol for degradation.ER-phagy,which is an ERAD pathway,also controls the quality and abundance of proteins and organelles by activating ERresident receptors.ER membrane is the important site of initiation for phagophores(crescent-shaped membranes that form and mature into autophagosomes);however,specific sites that are restricted on ER during ER-phagy remain to be identified.Recently,Cui et al.[1]found that a COPII coat subunit,Lstl/SEC24C-Sec23,plays an unconventional role in targeting ER domains for degradation of the ER-phagy receptor,which makes them essential to ER-phagy.

关 键 词：HOMEOSTASIS shaped POTENTIAL 

分 类 号：Q26[生物学—细胞生物学]