PRESENILIN

作品数：29被引量：62H指数：5
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相关作者：贾建平叶承金王晓平张应玖徐广伟更多>>
相关机构：华东师范大学首都医科大学宣武医院第二军医大学东南大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《解剖学杂志》《China Medical Abstracts(Internal Medicine)》更多>>
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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways被引量：1
《Neural Regeneration Research》2025年第9期2706-2726,共21页Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li 
supported by the National Natural Science Foundation of China,No.82001155(to LL);the Natural Science Foundation of Zhejiang Province,No.LY23H090004(to LL);the Natural Science Foundation of Ningbo,No.2023J068(to LL);the Fundamental Research Funds for the Provincial Universities of Zhejiang Province,No.SJLY2023008(to LL);the College Students'Scientific and Technological Innovation Project(Xin Miao Talent Plan)of Zhejiang Province,No.2022R405A045(to CC);the Student Research;Innovation Program(SRIP)of Ningbo University,Nos.20235RIP1919(to CZ),2023SRIP1938(to YZ);the K.C.Wong Magna Fund in Ningbo University。
A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating d...
关键词：acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites 
Effects of lipids on the activity and structural dynamics of gamma secretase: A study using coarse-grained molecular dynamics simulations
《ChemPhysMater》2024年第3期303-313,共11页Ahmad Sajjad Jinfei Mei Chuanbo Wang Hongqi Ai 
supported by Shandong Provincial Natural Science Foundation of China(ZR2022MB073).
Gamma secretase(GS)is an intramembranous enzyme that acts on the amyloid precursor protein and Notch inside lipid membranes.The enzyme is responsible for amyloid-β propagation,one of the well-known causes of Alzheime...
关键词：Five lipids Gamma secretase PRESENILIN NICASTRIN Effect of lipid on GS 
Investigational treatments for neurodegenerative diseases caused by inheritance of gene mutations:lessons from recent clinical trials
《Neural Regeneration Research》2023年第8期1679-1683,共5页Bruno P.Imbimbo Viviana Triaca Camillo Imbimbo Robert Nisticò 
We reviewed recent major clinical trials with investigational drugs for the treatment of subjects with neurodegenerative diseases caused by inheritance of gene mutations or associated with genetic risk factors.Specifi...
关键词：Alzheimer's disease amyotrophic lateral sclerosis amyloid precursor protein GLUCOCEREBROSIDASE HUNTINGTIN Huntington's disease Parkinson's disease presenilin 1 presenilin 2 superoxide dismutase 1 
Converging links between adult-onset neurodegenerative Alzheimer’s disease and early life neurodegenerative neuronal ceroid lipofuscinosis?被引量：1
《Neural Regeneration Research》2023年第7期1463-1471,共9页Marcel Klein Guido Hermey 
supported by the Deutsche Forschungsgemeinschaft(DFG,425373668,HE 3220/4-1)(to GH).
Evidence from genetics and from analyzing cellular and animal models have converged to suggest links between neurodegenerative disorders of early and late life.Here,we summarize emerging links between the most common ...
关键词：Alzheimer’s disease autophagy Batten disease CLN3 disease dementia ENDOSOME LYSOSOME neurodegeneration neuronal ceroid lipofuscinosis PRESENILIN 
Presenilin and Alzheimer’s disease interactions with aging,exercise and high-fat diet:A systematic review
《BIOCELL》2023年第1期41-49,共9页YINGHUI GAO DENGTAI WEN SHIJIE WANG JINGFENG WANG 
This work was supported by the National Natural Science Foundation of China[Grant No.32000832];the Shandong Province Natural Science Foundation[Grant No.ZR2020QC096].
Presenilin(Psn)protein is associated with organismal aging.Mutations in the Psn gene may lead to Alzheimer’s disease(AD),dilated cardiomyopathy(DCM),and many age-dependent degenerative diseases.These diseases serious...
关键词：Genetic mutations DROSOPHILA Cardiac aging Muscle aging Neurodegenerative disease 
APOE ε4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer’s disease被引量：1
《Translational Neurodegeneration》2022年第1期248-261,共14页Hongwon Kim Siyoung Kim Byounggook Cho Jaein Shin Jongpil Kim 
Ministry of Science and ICT,and Ministry of Health and Welfare(2021M3E5E5096464,Republic of Korea);Basic Science Research Program of the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2022R1A6A1A03053343).
Background: The ε4 allele of apolipoprotein E (APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it is not clear how APOE ε...
关键词：Alzheimer’s disease Direct conversion Apolipoprotein E Induced neuron AMYLOID PRESENILIN 
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
《Neural Regeneration Research》2022年第1期31-37,共7页Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre 
supported by the Consejo Nacional de Ciencia y Tecnología Scholarship 711893(to MAH)and 711874(to EER)。
The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressiv...
关键词：familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex 
MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing被引量：7
《Neural Regeneration Research》2021年第10期2099-2108,共10页Li Zeng Hai-Lun Jiang Ghulam Md Ashraf Zhuo-Rong Li Rui Liu 
This study was supported by the National Natural Science Foundation of China(General Program),No.81673411;the United Fund Project of National Natural Science Foundation of China,No.U1803281;Young Medical Talents Award Project of Chinese Academy of Medical Sciences,No.2018RC350013;Chinese Academy of Medical Sciences Innovation Project for Medical Science,No.2017-I2M-1-016(all to RL).
In a previous study,we found that long non-coding genes in Alzheimer’s disease(AD)are a result of endogenous gene disorders caused by the recruitment of microRNA(miRNA)and mRNA,and that miR-200a-3p and other represen...
关键词：3ʹ-untranslated region Alzheimer’s disease BIOMARKER cerebral cortex Gene Ontology high-throughput sequencing intracellular neurofibrillary tangles microtubule-associated protein-τ miRNA-mRNA network presenilin 1 
Investigation of a Chinese pedigree with early-onset familial Alzheimer’s disease caused by presenilin 1 p.M233T mutation
《China Medical Abstracts(Internal Medicine)》2019年第2期122-123,共2页WU Si 
Objective To analyze the clinical presentation andgenotype of a Chinese pedigree with early-onset familialAlzheimer's disease. Methods A pedigree with early-onsetfamilial Alzheimer's disease was recruited. The clinica...
关键词：Alzheimer a CHINESE PEDIGREE EARLY-ONSET FAMILIAL Alzheimer’s disease 
Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models被引量：1
《Translational Neurodegeneration》2019年第1期433-449,共17页Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler 
This work has been developed and supported through the LABEX(excellence laboratory,program investment for the future)DISTALZ(Development of lnnovative Strategies for a Transdisciplinary approach to ALZheimers disease)and by Fondation Alzheimer.A.Be and A.Bo were granted from DISTALZ.
Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with th...
关键词：Extracellular vesicles C99 APP-CTFs Homo-and hetero-oligomerization ENDOSOMES LYSOSOMES trans-Golgi network SorLA γ-Secretase inhibition Presenilin knockout Alzheimer’s disease 
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