CAPSID

作品数：52被引量：132H指数：5
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相关作者：刘思远王乃东朱国强叶超杨佳佳更多>>
相关机构：湖南农业大学扬州优邦生物药品有限公司科技实业有限公司扬州大学更多>>
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猪Lck蛋白在猪圆环病毒2型体外复制过程中的作用
《畜牧兽医学报》2024年第12期5751-5761,共11页刘伟姣 何庆 蒋一凡 曹思雨 张时瑞 吕佳璐 龙娉 杨凌宸 周川 王乃东 
湖南省自然科学基金面上项目(2022JJ30298);湖南省技术攻关“揭榜挂帅”项目(2021NK1030);湖南省大学生创新创业训练计划一般项目(S202310537036)。
为了鉴定猪圆环病毒2型(PCV2)侵染细胞建立感染的重要宿主因子,本文分析在PK-15细胞中猪淋巴细胞特异性酪氨酸激酶Lck表达及活性对PCV2感染复制的影响,确定Lck是调控PCV2感染复制的新靶点。首先,本研究基于猪Lck结构特性和序列保守性分...
关键词：PCV2 CAPSID LCK SH3结构域 病毒复制 
Sunlenca■(Lenacapavir):A first-in-class,long-acting HIV-1 capsid inhibitor for treating highly multidrug-resistant HIV-1 infection
《Acta Pharmaceutica Sinica B》2024年第12期5512-5514,共3页Chunhua Ma Junbiao Chang Bin Yu 
support from the National Natural Science Foundation of China(Nos.22277110 and 82003585)and Tianjian Laboratory of Advanced Biomedical Sciences.
Lenacapavir,also known as GS-6207,under the brand name Sunlenca,was developed by Gilead Sciences Inc.It has been approved in the EU,Canada,and US for use alongside other antiretrovirals in adults with multidrug-resist...
关键词：Lenacapavir Capsid inhibitor HIV-1 infection HIV prevention Multidrug resistance Antiretroviral medication 
Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency被引量：1
《Journal of Integrative Medicine》2024年第1期72-82,共11页Jing-shun Meng Yun He Heng-bin Yang Li-ping Zhou Si-yuan Wang Xi-lin Feng Omar Yahya Al-shargi Xiao-min Yu Li-qing Zhu Chang-quan Ling 
sponsored by grants from the National Natural Science Foundation of China(No.82030117);the Wenzhou major scientific and technological innovation project(No.ZY2022001).
Objective Melittin and its derivatives have been characterized to establish effective gene delivery systems.Their capability of facilitating endosomal release enhances the nanoparticles-based gene delivery.Nevertheles...
关键词：MELITTIN Recombinant adeno-associated virus Capsid engineering Transduction efficiency 
Insights into varicella-zoster virus assembly from the B-and C-capsid at near-atomic resolution structures
《hLife》2024年第2期64-74,共11页Lei Cao Nan Wang Zhe Lv Wenyuan Chen Zhonghao Chen Lifei Song Xueyan Sha Guiqiang Wang Yaling Hu Xiaojun Lian Guoliang Cui Jinyan Fan Yaru Quan Hongrong Liu Hai Hou Xiangxi Wang 
supported by the Strategic Priority Research Program (XDB29010000);National Key Research and Development Program (2018YFA0900801);National Science Foundation Grants 32200135 and 12034006;supported by National Science Fund for Distinguished Young Scholar (No.32325004);the NSFS Innovative Research Group (No.81921005);supported by the Young Elite Scientists Sponsorship Program by CAST (2022QNRC001);the Youth Innovation Promotion Association of CAS grant;supported by the Special Research Assistant Project of the Chinese Academy of Sciences.
Varicella-zoster is a highly communicable virus that can be transmitted through the airborne route.About one quarter of people are infected with this virus.Previous studies have described the structure of A-capsid and...
关键词：varicella-zoster virus capsid structure virus assembly 
A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys
《Neuroscience Bulletin》2024年第1期90-102,共13页Yefei Chen Jingyi Wang Jing Liu Jianbang Lin Yunping Lin Jinyao Nie Qi Yue Chunshan Deng Xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu 
supported by Ministry of Science and Technology of China(2019YFA0903803 and 2018YFA0801404);National Natural Science Foundation of China(31871090,32000730,81961128019,and 81901397);Shenzhen Science and Technology Innovation Commission(JCYJ20190809171003698,JCYJ202103243001018,JCYJ20180507182505475,and JCYJ20180504165804015);Shenzhen Technological Research Center for Primate Translational Medicine(F-2021-Z99-504979);Youth Innovation Promotion Association(CAS 2017120);Chinese Academy of Sciences International Partnership Program(172644KYSB20170004);China Postdoctoral Science Foundation(2019M653115.);CAS Key Laboratory of Brain Connectome and Manipulation(2019DP173024);Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017);International Science and Technology Cooperation Base of Guangdong Province(2019A050505008).
Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural networks.However,few retro-gr...
关键词：Retrograde AAV Capsid variant Cortical projection neuron OPTOGENETICS Monkey 
The capsid revolution
《Journal of Molecular Cell Biology》2023年第11期1-11,共11页Ian A.Taylor Ariberto Fassati 
supported by the UK Medical Research Council(MR/W001241/1 to A.F.);the Canadian Institute of Health Research(PJT-178127 to A.F.);the Francis Crick Institute(to I.A.T.),with core funding from Cancer Research UK(CC2029);the UK Medical Research Council(CC2029);the Wellcome Trust(CC2029).
Lenacapavir,targeting the human immunodeficiency virus type-1(HIV-1)capsid,is the first-in-class antiretroviral drug recently approved for clinical use.The development of Lenacapavir is attributed to the remarkable pr...
关键词：HIV-1 capsid CPSF6 Lenacapavir INTEGRATION IP6 NUCLEUS reverse transcription 
Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators(2018-2022 update)被引量：2
《Chinese Chemical Letters》2023年第11期20-30,共11页Xiaoyu Shao Shujing Xu Xufeng Wan Yang Zhou Shuo Wang Shuo Wu Yuhuan Li Xinyong Liu Peng Zhan 
financial support from the National Natural Science Foundation of China(NSFC Nos.82173677,82211530493);the Science Foundation for Outstanding Young Scholars of Shandong Province(No.ZR2020JQ31).
Despite the improving coverage of preventative vaccines,hepatitis B remains a severe global public health problem,with more than 250 million patients living with hepatitis B virus(HBV)infection.Current available thera...
关键词：HBV CAPSID CpAMs Medicinal chemistry strategies Drug design 
Elucidating cellular interactome of chikungunya virus identifies host dependency factors被引量：1
《Virologica Sinica》2023年第4期497-507,共11页Peiqi Yin Xia Jian Yihan Liu Yuwen Liu Lu Lv Haoran Cui Leiliang Zhang 
supported by National Natural Science Foundation of China (82072270 and 82272306);Taishan Scholars Program (tstp20221142);Shandong Provincial Natural Science Foundation (ZR2021QC095);Academic Promotion Programme of Shandong First Medical University (2019LJ001).
Chikungunya virus(CHIKV)is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain.To better understand how CHIKV rewires the host cell and usurps host cell functions,we generated a systematic CHIKV...
关键词：Chikungunya virus(CHIKV) INTERACTOME STIP1 homology and U-box containing protein 1(STUB1) Valosin-containing protein(VCP) CAPSID 
鸭坦布苏病毒Capsid蛋白原核表达及多克隆抗体制备被引量：1
《中国畜牧兽医》2023年第6期2395-2402,共8页焦琳琳 成玉婷 吴庆国 吴双 吴植 朱善元 钱莺娟 
江苏省高等学校自然科学研究面上项目(22KJB230005);“凤城英才”青年科技人才托举工程项目(泰科协发[2021]45号);江苏农牧科技职业学院校级科研课题(NSF2021CB05);江苏省大学生创新创业训练计划项目(202112806011Y)。
【目的】本研究选择原核表达系统表达鸭坦布苏病毒(Duck Tembusu virus,DTMUV)核衣壳蛋白(Capsid protein),并制备其多克隆抗体,为DTMUV分子机制研究奠定基础。【方法】根据DTMUV-201909株基因序列,运用一步克隆技术将Capsid基因克隆至...
关键词：鸭坦布苏病毒(DTMUV) 核衣壳蛋白 原核表达 多克隆抗体 
Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity被引量：3
《Acta Pharmaceutica Sinica B》2023年第5期2219-2233,共15页Fuhua Wu Shuang Luo Yongshun Zhang Yangsen Ou Hairui Wang Zhaofei Guo Chunting He Shuting Bai Penghui He Min Jiang Xiaoyan Chen Guangsheng Du Xun Sun 
the National Natural Science Foundation of China,China(Grant Nos.81925036 and 81872814);the Key Research and Development Program of Science and Technology Department of Sichuan Province,China(Grant No.2020YFS0570);111 project,China(Grant No.B18035);the Fundamental Research Funds for the Central Universities,China。
Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines,the epidemic prevention and control are still challenging.Here,we employ a capsid and antige...
关键词：AAV vectors Capsid engineering VACCINE Antigen structure design SARS-CoV-2 
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