云南高校图书馆联盟文献共享服务平台- MELITTIN

MELITTIN: 作品数：52被引量：112H指数：6; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：杨申张雪梅李柏郭忠张福林更多>>; 相关机构：中国农业大学第二军医大学南京师范大学复旦大学更多>>; 相关期刊：《Communications in Theoretical Physics》《北方药学》《中华微生物学和免疫学杂志》《商丘师范学院学报》更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家科技支撑计划“九五”国家科技攻关计划更多>>

蜂毒及其主要活性成分蜂毒肽(Melittin)对癌症的作用及机制: 《蜜蜂杂志》2025年第3期13-15,共3页方子祺胡福良(指导); 蜂毒是蜜蜂用于抵御天敌的一种重要武器,传统认为蜂毒中的化学成分对生物具有毒性,但近年来其在癌症治疗中具有潜在应用价值。文章对国内外有关蜂毒及其主要活性成分蜂毒肽(Melittin)对癌症的作用及其机制的研究进展进行了综述,并对蜂...; 关键词：蜂毒蜂毒肽(Melittin) 癌症

Melittin enhanced intracellular trehalose with synergistic membrane stabilization of macromolecular protectants for cell cryopreservation: 《Science China(Technological Sciences)》2024年第4期1160-1169,共10页NIU QingJing GAO ShuHui ZHU KongYing REN LiXia YUAN XiaoYan; Cryopreservation plays an essential role in biobanking and cell therapy,but the physiological toxicity of traditional cryoprotectants such as glycerol and dimethyl sulfoxide(DMSO)has raised safety issues for biomedica...; 关键词：MELITTIN intracellular trehalose membrane stabilization macromolecular protectants cell cryopreservation

Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency被引量：1: 《Journal of Integrative Medicine》2024年第1期72-82,共11页Jing-shun Meng Yun He Heng-bin Yang Li-ping Zhou Si-yuan Wang Xi-lin Feng Omar Yahya Al-shargi Xiao-min Yu Li-qing Zhu Chang-quan Ling; sponsored by grants from the National Natural Science Foundation of China(No.82030117);the Wenzhou major scientific and technological innovation project(No.ZY2022001).; Objective Melittin and its derivatives have been characterized to establish effective gene delivery systems.Their capability of facilitating endosomal release enhances the nanoparticles-based gene delivery.Nevertheles...; 关键词：MELITTIN Recombinant adeno-associated virus Capsid engineering Transduction efficiency

Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy: 《Asian Journal of Pharmaceutical Sciences》2024年第1期135-146,共12页Sujie Huang Yuxuan Gao Ling Ma Bo Jia Wenhao Zhao Yufan Yao Wenyuan Li Tongyi Lin Rui Wang Jingjing Song Wei Zhang; supported by the grants from the National Natural Science Foundation of China(Nos.81773566 and 21602092);Innovation Project of Medicine and Health Science and Technology of Chinese Academy of Medical Sciences(2019-I2M-5-074);the Funds for Fundamental Research Creative Groups of Gansu Province(No.20JR5RA310);the Fundamental Research Funds for the Central Universities(No.lzujbky-2021-38).; Melittin,a classical antimicrobial peptide,is a highly potent antitumor agent.However,its significant toxicity seriously hampers its application in tumor therapy.In this study,we developed novel melittin analogs with ...; 关键词：Antimicrobial peptide Peptide-drug conjugate Cell-penetrating activity Membrane disruption Antitumor activity

Metal–Phenolic Network-Facilitated“Foe-to-Friend”Conversion of Melittin for Cancer Immunotherapy with Boosted Abscopal Effect被引量：1: 《Research》2023年第3期727-739,共13页Yuxin Guo Xinping Zhang Shao-Zhe Wang Hui-Heng Feng Shun-Yu Wu Fu-Gen Wu; the Natural Science Foundation of Jiangsu Province(BK20211510);the National Natural Science Foundation of China(21673037)。; As a naturally occurring cytolytic peptide,melittin(Mel)has strong cytolytic activity and is a potent therapeutic peptide for cancer therapy.However,the serious hemolytic activity of Mel largely impedes its clinical a...; 关键词：STIMULATION loaded considerably

The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitro and in vivo被引量：2: 《Journal of Integrative Medicine》2023年第1期106-116,共11页Yi-lin Xie Ji-yao Wang Yun He Xiao-min Yu Qing-yun Zheng Chen Ling Xi-lin Feng Li-qing Zhu; This work was sponsored by grants from the National Natural Science Foundation of China,(No.81972713 to CL);the Natural Science Foundation of Zhejiang Province(No.LY22H200004 to LZ);the Traditional Chinese Medicine Science and Technology Program Project of Zhejiang Province(No.2021ZB181 to LZ);CL is supported by the Oriental Scholars of Shanghai Universities(No.GZ2020001)。; Objective: Melittin, a cell-penetrating peptide, improves the efficiency of many non-viral gene delivery vectors, yet its application in viral vectors has not been well studied. The non-pathogenic recombinant adeno-as...; 关键词：TAAV MELITTIN Capsid engineering CO-ADMINISTRATION Transduction efficiency

Electrochemiluminescence Imaging of Liposome Permeabilization by an Antimicrobial Peptide:Melittin: 《Chemical & Biomedical Imaging》2023年第1期58-65,共8页Fatma Ben Trad Jérôme Delacotte Manon Guille-Collignon Frédéric Lemaître Stéphane Arbault Neso Sojic Fabienne Burlina Eric Labbé Olivier Buriez; supported in parts by CNRS UMR 8640,Ecole Normale Supérieure,PSL University and Sorbonne Université.F.B.T.thanks the doctoral school ED388“Chimie Physique et de Chimie Analytique de Paris Centre”for a PhD grant.We thank Gilles Clodic(MS3U platform,Sorbonne Université)for MALDI-TOF mass spectrometry analysis.N.S.acknowledges the financial support from Agence Nationale de la Recherche(ELISE-ANR-21-CE42).; The permeabilization of liposomes by melittin,an antimicrobial peptide(AMP),has been studied by an electrochemiluminescence(ECL)imaging strategy.The methodology consisted ffrst of encapsulating ECL reagents in sealed ...; 关键词：ELECTROCHEMILUMINESCENCE LIPOSOME ECL imaging PERMEABILIZATION Membrane active peptide MELITTIN

Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy被引量：2: 《Bioactive Materials》2022年第3期541-553,共13页Yuhan Zhou Ting Ye Chengzhi Ye Chao Wan Siyue Yuan Yushuai Liu Tianyu Li Fagang Jiang Jonathan F.Lovell Honglin Jin Jing Chen; This work was supported by the National Natural Science Foundation of China(No.81773285,81874233 and 82022040);Health Commission of Hubei Province scientific research project(WJ2021Z004);Scientific Research Project of Hubei Provincial Health and Family Planning Commission,China(WJ2015MB017 to J.C.).; Autologous tumor cells and cell-derived secretions(CDS)can induce antitumor immune responses.The conditions in which cells are cultured and treated impact CDS,and cellular insults alter their composition and function....; 关键词：Cancer immunotherapy HYDROGEL MELITTIN Anti-PD-1 Cell-derived secretions

SP94-melittin与RGD-melittin杂合肽抗肿瘤性及溶血性研究: 《商丘师范学院学报》2022年第3期43-47,共5页曹静; 河南省科技厅项目(182102310677)。; 目的:比较连接有不同肿瘤靶向头的抗菌肽SP94-melittin、RGD-melittin与单独的melittin三者抗肿瘤性以及溶血性的差异,寻找能够减毒增效的新型靶向抗肿瘤药物.方法:选择抗菌肽melittin分别与不同特异性的肿瘤细胞靶向肽SP94、RGD连接,...; 关键词：抗菌肽靶向抗肿瘤性溶血性

Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect被引量：4: 《Acta Pharmacologica Sinica》2021年第8期1256-1266,共11页Xue-gong Fan Si-ya Pei Dan Zhou Peng-cheng Zhou Yan Huang Xing-wang Hu Teng Li Yang Wang Ze-bing Huang Ning Li; supported by the project funded by China Postdoctoral Science Foundation(no's.2016M600639 and 2017T100614);the National Natural Science Foundation of China(no's.81673719,81970550,81700561 and 81873574);Natural Science Foundation of Hunan Province(no's.2019JJ30042 and 11JJ6072)。; Acute liver failure(ALF)is a fatal clinical syndrome with no special drug.Recent evidence shows that modulation of macrophage to inhibit inflammation may be a promising strategy for ALF treatment.In this study we inve...; 关键词：MELITTIN acute liver failure M2-type pyruvate kinase GLYCOLYSIS Warburg effect INFLAMMATION Akt/mTOR/PKM2/HIF-1αsignaling

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