supported in parts by CNRS UMR 8640,Ecole Normale Supérieure,PSL University and Sorbonne Université.F.B.T.thanks the doctoral school ED388“Chimie Physique et de Chimie Analytique de Paris Centre”for a PhD grant.We thank Gilles Clodic(MS3U platform,Sorbonne Université)for MALDI-TOF mass spectrometry analysis.N.S.acknowledges the financial support from Agence Nationale de la Recherche(ELISE-ANR-21-CE42).
The permeabilization of liposomes by melittin,an antimicrobial peptide(AMP),has been studied by an electrochemiluminescence(ECL)imaging strategy.The methodology consisted ffrst of encapsulating ECL reagents in sealed ...
supported by the National Natural Science Foundation of China(No.81772714).
Objective:It has been reported that intrinsic apoptosis is associated with the progression of bladder cancer(BC).Recent evidence suggests that polyribonucleotide nucleotidyltransferase 1(PNPT1)is a pivotal mediator in...
The increased importance of the G. mellonella for wide range of scientific research and commercial sides will need to create a germplasm resource banking by cryopreservation. Impermeability is a fundamental limiting f...
Supported by the grants from the National Natural Science Foundation of China(21176220,20876143,31470793);the Natural Science Foundation of Zhejiang Province(Z13B060008);the Key Technology Research and Development Project of Ningbo(2011C11023)
The activity of whole-cell biocatalysts is strongly compromised by the cell envelope, which is a permeability harrier against the diffusion of substrates and products. Although common chemical or physical permeahiliza...
According to epidemiological studies,twice as many women as men are affected by irritable bowel syndrome(IBS)in western countries,suggesting a role for sex hormones in IBS pathophysiology.Despite growing evidence abou...
Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domainlike (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis. Upon...
This study reports the capacity of three nitro substituted benzazolo[3,2-a]quinolinium salts NBQs: NBQ 95 (NSC-763304), NBQ 38 (NSC 763305), and NBQ 97 (NSC-763306) as potential antitumor agents. NBQ’s are unnatural ...
Many conventional anticancer drugs have an associated lack of safety by their toxicity. Relatively faster mutations in tumor cells pose a significant obstacle in treatment of cancer. Recently, “Mitocans” have emerge...
We reported previously that chymotrypsin B is cached in the lysosomes of rat hepatocytes and mediates apoptosis induced by TNF-alpha (1) and H2O2. However, the mechanism
The p53 protein is mutated or inactivated in more than 50% of human cancers, underscoring its cardinal importance as an oncosuppressor, p53 is expressed in all nucleated cells and can be activated by a plethora of pos...