PROTEOLYTIC

作品数：32被引量：99H指数：6
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he BCM1-EGY1 module balances chlorophyll biosynthesis and breakdown to confer chlorophyll homeostasis in land plants
《Molecular Plant》2025年第1期76-94,共19页Dali Fu Hanlin Zhou Bernhard Grimm Peng Wang 
supported by funds from the Deutsche Forschungsgemeinschaft(FOR2092,GR 936/18-1,SFB TRR175,subproject C04,and WA 4599/2-2);the National Natural Science Foundation of China(Excellent Young Scientists Fund for Hong Kong and Macao,32322089);the Research Grant Council of Hong Kong(Early Career Scheme,27118022;and General Research Fund,17107223);the State Key Laboratory of Agrobiotechnology at the Chinese University of Hong Kong(the ITC Funding);the University of Hong Kong(the Seed Fund for Basic Research,66620211115918 and the Startup fund);Any opinions,findings,conclusions,or recommendations expressed in this publication do not reflect the views of the Government of the Hong Kong Special Administrative Region or the Innovation and Technology Commission.
Chlorophyll metabolism has evolved during plant evolution.The strictly light-dependent nature of chlorophyll biosynthesis found in angiosperms requires tight coordination of chlorophyll biosynthesis and breakdown to a...
关键词：chlorophyll homeostasis scaffold protein BCM1 proteolytic machinery EGY1 post-translational control 
Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects被引量：1
《International Journal of Oral Science》2024年第3期539-552,共14页Fen Liu Bofeng Zhu Ying An Zhifei Zhou Peiying Xiong Xuan Li Yang Mi Tongqiang He Faming Chen Buling Wu 
supported by the Major Research Program of the National Natural Science Foundation of China(Subproject No.81991503);the Youth Research Program of the National Natural Science Foundation of China(No.82201069);the Innovative Talent Promotion Plan of Shaanxi Province-Research Fund for Young Star of Science and Technology(No.2021KJXX-24,No.2022KJXX-100);Basic and Applied Basic Research Fund of Guangdong Province(No.2023A1515012126).
Periodontitis is a critical risk factor for the occurrence and development of diabetes.Porphyromonas gingivalis may participate in insulin resistance(IR)caused by periodontal inflammation,but the functional role and s...
关键词：gingivalis INFLAMMATION resistance 
Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma
《Oncology Research》2024年第4期679-690,共12页XINFENG ZHANG SHUANG LI MEIRU SONG YUE CHEN LIANGZHENG CHANG ZHERUI LIU HONGYUAN DAI YUTAO WANG GANGQI YANG YUN JIANG YINYING LU 
supported by the National Natural Science Foundation of China Fund Project(82272956).
Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expr...
关键词：Hepatocellular carcinoma(HCC) Focal adhesion kinase(FAK) Proteolytic targeting chimera technology(PROTAC) Epithelial-mesenchymal transformation(EMT) METASTASIS 
Non-proteolytic ubiquitination of HBx controls HBV replication
《Virologica Sinica》2024年第2期338-342,共5页Xiangpeng Sheng Yi Yang Min Zhu Linlin Zhou Fang Zhu Yuanfei Zhu Siying Dong Hui Kong Honghua Wang Ji Jiang Mingyue Wan Mingyang Feng Qiang Deng Yumin Xu Qing You Ronggui Hu 
funded by the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900);the Ministry of Science and Technology of China(No.2019YFA0802103);the National Natural Science Foundation of China(No.92253302);the Department of Science and Technology of Zhejiang Province(No.2021C03104);the Guangzhou Science Innovation and Development Program(No.201803010092);athe Shenzhen-Hong Kong Institute of Brain Science(No.NYKFKT2019006).
Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health threat.Persistent HBV infection remains the principal cause of liver cirrh...
关键词：INFECTION CIRRHOSIS 
Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing被引量：1
《Cell Research》2023年第7期516-532,共17页Christopher C.Pan Raquel Maeso-Díaz Tylor R.Lewis Kun Xiang Lianmei Tan Yaosi Liang Liuyang Wang Fengrui Yang Tao Yin Calvin Wang Kuo Du De Huang Seh Hoon Oh Ergang Wang Bryan Jian Wei Lim Mengyang Chong Peter B.Alexander Xuebiao Yao Vadim Y.Arshavsky Qi-Jing Li Anna Mae Diehl Xiao-Fan Wang 
supported by grants from National Institutes of Health(R01CA244564 to X.F.W.,R01DK077794 to A.M.D.);Duke Eye Center EM Facility Core(P30EY005722 to V.Y.A.);NIH Pathway to Independence Award(K99EY033763 to T.R.L.);Florence McAlister Professorship of Medicine(A.M.D.).
Cellular senescence is a stress-induced,stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment,leading to chronic inflammation and age-associated diseases.Determining the fundamental mo...
关键词：homeostasis initiated IRREVERSIBLE 
Calcium supplementation in low nutrient density diet for meat ducksimproves breast meat tenderness associated with myocyte apoptosisand proteolytic changes被引量：1
《Animal Nutrition》2022年第2期49-59,共11页Huaiyong Zhang Quifeng Zeng Shiping Bai Jianping Wang Xuemei Ding Yue Xuan Zhuowei Su Joris Michiels Keying Zhang 
the“111”Project;the financial support by China Agriculture Research System of MOF and MARA.
To define the relationship between dietary nutrient density, calcium (Ca), and meat quality in meatducks. A total of 288 male Cherry Valley SM3 medium ducklings were fed a common standard starter dietuntil d 14. At 15...
关键词：Nutrient density Ca TENDERNESS Meat duck 
Trimethylamine Adsorption Mechanism on Activated Carbon and Removal in Water and Oyster Proteolytic Solution被引量：3
《Journal of Ocean University of China》2021年第6期1578-1586,共9页CHEN Deke WAN Peng CAI Bingna YE Ziqing CHEN Hua CHEN Xin SUN Huili PAN Jianyu 
the National Key R&D Program of China(No.2018YFC0311202);the Key-Area Research and Development Program of Guang-dong Province(No.2020B1111030004);the Science and Technology Program of Guangzhou,China(Nos.201804010364 and 201804010321);the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0406);the National Key R&D Program of China(No.2018YFC0311202);the Natural Science Foun-dation of Guangdong Province,China(Nos.2018A030313088,2018A030313626);the Academician Work-station Foundation for Young Scientists of Chinese Aca-demy of Sciences Guangzhou Branch(No.20180313).
In this study,seven coal-based activated carbons(ACs)were adopted to remove trimethylamine(TMA)in an aqueous solution as environmentally friendly and harmless adsorbents.The results showed that columnar AC(CAC)had a c...
关键词：TRIMETHYLAMINE activated carbon adsorption mechanism OYSTER proteolytic solution 
Role of ethylene and proteolytic N-degron pathway in the regulation of Arabidopsis seed dormancy被引量：1
《Journal of Integrative Plant Biology》2021年第12期2110-2122,共13页Xu Wang Malaika Maraya Gomes Christophe Bailly Eiji Nambara Francoise Corbineau 
a scholarship from China Scholarship Council。
Primary dormant seeds of Arabidopsis thaliana did not germinate in darkness at temperature higher than 10–15℃.Ethylene improved the germination of dormant wild-type(Col-0)seeds at 25℃ in darkness but seeds of the m...
关键词：abscisic acid/gibberellin Arabidopsis thaliana L DORMANCY Ethylene Response Factors ETHYLENE germination N-degron pathway proteolysis6 
AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions
《Neural Regeneration Research》2021年第5期851-855,共5页Jeffrey ALowell Kar Men Mah John LBixby Vance PLemmon 
This work was supported by grants to JLB and VPL from the National Institutes of Health(NS100531);the Craig H.Neilsen Foundation(598684);the Miami Project to Cure Paralysis.VPL holds the Walter G.Ross Distinguished Chair in Developmental Neuroscience.
Adeno-associated virus(AAV)is an essential instrument in the neuroscientist’s toolkit,which allows delivery of DNA to provide labeling with fluorescent proteins or genetic instructions to regulate gene expression.In ...
关键词：adeno-associated virus autolytic CAPSID low pH PROTEASE PROTEOLYTIC temperature TRAFFICKING TRANSDUCTION viral inactivation 
Effect of proteolytic starter culture isolated from Chinese Dong fermented pork(Nanx Wudl)on microbiological,biochemical and organoleptic attributes in dry fermented sausages被引量：12
《Food Science and Human Wellness》2021年第1期13-22,共10页Xi Chen Ruifang Mi Biao Qi Suyue Xiong Jiapeng Li Chao Qu Xiaoling Qiao Wenhua Chen Shouwei Wang 
the National Key R&D Program of China(grant no.2018YFD0400404).
The effect of a proteolytic starter culture isolated from Nanx Wudl,on microbiological,biochemical and organoleptic attributes of dry fermented sausages was investigated during processing.Based on preliminary screenin...
关键词：Staphylococcus xylosus proteolytic activity Lactobacillus plantarum Nanx Wudl fermented sausage 
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