PROTEASE

作品数:332被引量:727H指数:11
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相关领域:医药卫生生物学更多>>
相关作者:杨鹏李云曹文静李伟国肖进更多>>
相关机构:清华大学北京大学武汉大学中国科学院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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A dual-protease-triggered chemiluminescent probe for precise tumor imaging
《Chinese Chemical Letters》2025年第2期274-278,共5页Zhihui Zhang Ru Sun Chong Bian Hongbo Wang Zhen Zhao Panpan Lv Jianzhong Lu Haixin Zhang Hulie Zeng Yuanyuan Chen Zhijuan Cao 
financial support by National Key R&D Program of China,MOST(No.2023YFC2510000);Shanghai Science and Technology(No.21N31900500);Shanghai Municipal Health Commission Project(No.202140016);Training Program for Outstanding Young Medical and Pharmaceutical Talents of Minhang District Health System(No.mwyjyx08);the Project of Basic Medicine funded by Fudan-Minhang Health Consortium(Nos.2021MHJC10 and 2023FM09)。
Imaging detection of interlinked dual proteases is imperative for precise tumor imaging,which remains challenging due to limited modification position of specific substrate and possible steric hindrance.Herein,we have...
关键词:Dual-protease imaging Tripeptide substrate Chemiluminescent Phenoxy-dioxetane scaffold Logic gates 
The regulatory network and critical factors promoting programmed cell death during embryogenesis
《Journal of Integrative Plant Biology》2025年第1期55-70,共16页An Luo Ce Shi Pan Luo Zifu Zhao Meng-Xiang Sun 
financially supported by the National Natural Science Foundation of China(31700281,32000248,32130031);the Postdoctoral Science Foundation of China(BX20200256,2020M682466)。
Programmed cell death(PCD)is essential for animal and plant development.However,the knowledge of the mechanism regulating PCD in plants remains limited,largely due to technical limitations.Previously,we determined tha...
关键词:programmed cell death PROTEASE reactive oxygen species SUSPENSOR TRANSCRIPTOME 
Sanhan Huashi Formula and Its Bioactive Compounds Exert Antiviral and Anti-Inflammatory Effects on COVID-19
《Engineering》2024年第12期159-172,共14页Chuanxi Tian Hang Liu Qian Wang Jinyue Zhao Chensi Yao Yanfeng Yao Xu Zhang Qinhai Ma Weihao Wang Yanyan Zhou Mengxiao Wang Xiaomeng Shi Xiangyan Li Shan Wang Yingying Yang Xiaowen Gou Lijuan Zhou Jingyi Zhao Li Wan Jiarui Li Stefanie Tiefenbacher Juntao Gao Rudolf Bauer Min Li Xiaolin Tong 
supported by the National Key Research and Development Program of China(2021YFE0201100 and 2022YFC0868300);the National Natural Science Foundation of China(22107004)。
Sanhan Huashi formula(SHHS),a traditional Chinese medicine(TCM),has shown significant therapeutic effects on coronavirus disease 2019(COVID-19)in clinical settings.However,its specific mechanism and components still r...
关键词:Sanhan Huashi formula Coronavirus disease 2019 Anti-inflammatory properties Nodakenin 3C-like protease 
Unveiling the dynamic role of innate and adaptive immune cells in COPD pathogenesis induced by cigarette smoke
《Life Research》2024年第4期29-41,共13页Dur E Maknoon Razia Syed Sib Tul Hassan Shah Tabish Faheem 
Chronic obstructive pulmonary disease(COPD)is a multifaceted syndrome characterized by a dysregulated inflammatory cascade within the respiratory system,primarily triggered by exposure to harmful particles and gases,n...
关键词:chronic obstructive pulmonary disease innate immunity adaptive immunity cigarette smoke inflammation oxidative stress protease-antiprotease imbalance 
Addition of Protease Enzyme to Dog and Cat Feed and Its Influence on the Digestibility Coefficient, Immune Response, and Metabolic Biomarkers
《Food and Nutrition Sciences》2024年第11期1043-1054,共12页Bruno Giorgio de Oliveira Cécere Emanuela Cristina Zatti Anzigliero Angelo Schonorr Thiago Pereira Ribeiro Walter Hugo Cuelho Suarez Daniel Pigatto Monteiro Aleksandro S. Da Silva 
Promoting better protein digestibility through exogenous enzymes in the diet is essential in the nutrition of companion animals, mainly for better performance and maintenance of the animals’ physiological and metabol...
关键词:CANINES Diet Enzymes exogenous FELINES Metabolism 
Research on the quality deterioration of UHT milk products during shelf life:core microorganisms and related characteristics
《Food Science and Human Wellness》2024年第5期2866-2875,共10页Ruixue Ding Kairu He Rina Wu Mengxue Lou Zhili Liu Yuqiong Piao Xiaoyan Liu Zhishen Mu Junrui Wu 
supported by the National Natural Science Foundation of China(32172279,31871831);Shenyang Science and Technology Innovation Platform Project(21-103-0-14,21-104-0-28);Shenyang City Youth Science and Technology Innovation Leading Talent Project(RC200495).
Commercial sterility does not guarantee the sustained stability of ultrahigh temperature(UHT)milk over 6 months shelf life.We explore the microbiota presented in normal(SZ)and quality deteriorated UHT milk(QY and WY)p...
关键词:Ultrahigh temperature(UHT) Quality deterioration High-throughput sequencing Core functional microbiota LIPASE PROTEASE 
Biomineralized synthesis of luminescent protease-(NH_(4))_(2)Y_(3)F_(11)·H_(2)O hybrid nanospheres and their applications as a stable and reusable enzyme reactor
《Collagen and Leather》2024年第3期107-118,共12页Wenyu Wei Manman He Jianrui Ma Huixia He Peng Liu Jianxi Xiao 
supported by grants from the National Natural Science Foundation of China(grant nos.22074057 and 21775059)
Proteases,such as trypsin,are essential for extracting collagen in various industrial applications.The potential applications of rare earth nanomaterials,specifically yttrium nanoparticles,have attracted significant i...
关键词:BIOMINERALIZATION NANOSPHERE PROTEASE Collagen 
Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A
《Virologica Sinica》2024年第4期685-693,共9页Yanyan Dong Enze Shao Siwei Li Ruiqi Wang Dan Wang Lixin Wang Hong Yang Yingxia He Tian Luan Yang Chen Yao Wang Lexun Lin Yan Wang Zhaohua Zhong Wenran Zhao 
supported by the National Natural Science Foundation of China(82172247 and 81971920 to WZ,82072278 to ZZ,and 82202493 to LL,82302502 to Yao Wang);Natural Science Foundation of Heilongjiang Province of China(YQ2023H003);China Postdoctoral Science Foundation(2021M693818);Heilongjiang Postdoctoral Fund,Heilongjiang Province of China(LBH-Z21023).
Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy.Group B coxsackievirus(CVB)is one of the leading causative pathogens of viral myocarditis,which prim...
关键词:BAICALEIN Coxsackievirus B(CVB) MYOCARDITIS 2A protease CASPASE-1 
Retraction: miR-148b Functions as a Tumor Suppressor by Targeting Endoplasmic Reticulum Metallo Protease 1 in Human Endometrial Cancer Cells
《Oncology Research》2024年第8期1379-1379,共1页Oncology Research Editorial Office 
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...
关键词:raised shaped BANDS 
The application of protease in aquaculture:Prospects for enhancing the aquafeed industry被引量:1
《Animal Nutrition》2024年第1期105-121,共17页Shiyou Chen Sahya Maulu Jie Wang Xiaoze Xie Xiaofang Liang Hao Wang Junjun Wang Min Xue 
supported by National Key Research and Development Program of China(2022YFD1300600);the Agricultural Science and Technology Innovation Program of CAAS,China(IFR-ZDRW202303);Beijing Innovation Consortium of Agriculture Research System(BAIC07-2023);Xinjiang key Research and Development Program(2022B02039-3)
Low-fishmeal and protein-saving diets are two prominent nutritional strategies utilized to address challenges related to the scarcity and sustainability of protein sources in aquaculture.However,these diets have been ...
关键词:PROTEASE Low-fishmeal diet Protein-saving diets Exogenous digestive enzyme Aquafeed 
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