Effect of celecoxib on improving depression:A systematic review and meta-analysis  

作　　者：Zhi Wang Qiao Wu Qing Wang 

机构地区：[1]Integrated Traditional Chinese Medicine&Western Medicine Department,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China [2]Department of Neurology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China [3]Department of Rehabilitation Center of Wuhan Puren Hospital,Wuhan University of Science and Technology,Wuhan 430080,Hubei Province,China

出　　处：《World Journal of Clinical Cases》2022年第22期7872-7882,共11页世界临床病例杂志

基　　金：Supported by the Sixth Batch of Wuhan Young and Middle-aged Medical Backbone Talents Training Project Wuhan Health and Family Planning Commission,No.[2018]116

摘　　要：BACKGROUND Anti-inflammation drugs were uncovered to be a potential therapy for depression.Celecoxib as a selective COX2 inhibitor is also one anti-inflammation drugs.Celecoxib is widely used in the clinic,which is well known by medical workers.It is uncertain whether celecoxib has efficacy in improving depression.AIM To estimate the effect of celecoxib on improving depression.METHODS All literature was searched until 2022.The databases included PubMed,OVID database,Cochrane library,Web of Science,CNKI,Clinicaltrials.gov database and Wanfang database.The random effects model was used to estimate the standardized mean differences with 95%CIs.With determined diagnostic criteria,studies containing patients with depression in the celecoxib group and the control group were included in the meta-analysis.The primary outcome measures were set for depression scale scores.RESULTS Twenty-nine randomized controlled studies were included in the meta-analysis(including 847 subjects with depression and 810 control subjects).The metaanalysis showed that celecoxib had an effect of anti-depression.At the same time,heterogeneity was observed(I2=82.1%,P=0.00),and meta-regression was implemented to estimate the source of heterogeneity,which showed that the type of depression scale and depression type may lead to the heterogeneity.Subgroup analysis with respect to depression scale and depression type suggested that depression type was the possible main source of heterogeneity.Moreover,Egger’s test,Begg’s test,funnel plot and Doi plot was implemented,and publication bias was found to be significant.Next,the trim and fill method was used to estimate the influence of publication bias on the outcome of the meta-analysis,which showed that the outcome of the meta-analysis was reliable.Sensitivity analysis was estimated by deleting a study one by one,and the outcome of the meta-analysis was significantly stable.The quality of all randomized controlled trial studies was assessed by risk of bias,which indicated the rank of evidence in the

关 键 词：CELECOXIB DEPRESSION Systematic review META-ANALYSIS INFLAMMATION 

分 类 号：R749.4[医药卫生—神经病学与精神病学]