MICROSOMES

作品数：40被引量：76H指数：4
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相关领域：医药卫生更多>>
相关作者：杨秀伟许振华周宏灏鲁文红王乃平更多>>
相关机构：北京大学华中科技大学湖南医科大学广西中医学院更多>>
相关期刊：《Asian Journal of Pharmaceutical Sciences》《Journal of Traditional Chinese Medical Sciences》《沈阳药科大学学报》《癌变．畸变．突变》更多>>
相关基金：国家自然科学基金国家科技支撑计划国家重点基础研究发展计划广西壮族自治区自然科学基金更多>>
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Enrichment of ER tubule-derived microsomes by differential centrifugation and immunoprecipitation
《Biophysics Reports》2024年第2期61-66,共6页Yiduo Liu Junjie Hu Bing Yan 
supported by grants from the National Key R&D Program of China(2021YFA1300800);Project for Young Scientists in Basic Research(YSBR-075)of the Chinese Academy of Sciences。
The endoplasmic reticulum(ER)is an essential component of the endomembrane system in eukaryotes and plays a crucial role in protein and lipid synthesis,as well as the maintenance of calcium homeostasis.Morphologically...
关键词：Endoplasmic reticulum MICROSOME Differential centrifugation IMMUNOPRECIPITATION 
Benoxacor is enantioselectively metabolized by microsomes and cytosol from the human liver
《Emerging Contaminants》2023年第1期10-19,共10页Derek Simonsen Jacob Heffelfinger David M.Cwiertny Hans-Joachim Lehmler 
supported by the National Science Foundation (NSF) [grant numbers CBET-1703796,CBET-1702610,CBET-1335711,CHE-1609791];the National Institute of Environmental Health Sciences/National Institute of Health [grant number P30 ES005605].
Benoxacor is a safener added to current-use herbicide formulations to protect the target crop from herbicidal toxicity.It is an emerging environmental contaminant that has been detected in surface waters,raising the p...
关键词：COR METABOLISM depletion 
Inhibitory Effects of Several Fluoroquinolones on Feline CYP1A and 3A in Hepatic Microsomes
《Open Journal of Veterinary Medicine》2020年第12期219-237,共19页Syed Sher Shah Sadaat Nasrin Stankzi Mohammad Monir Tawfeeq Farid Ahmad Tanin Amanullah Aziz Kazuki Sasaki 
In this study, the effects of several fluoroquinolones (FQs), such as Ciprofloxacin (CPFX);Orbifloxacin (OBFX);Norfloxacin (NFX);Ofloxacin (OFX);and Enerofloxacin (EFX) on activities of both Cytochrome P450 1A (CYP1A)...
关键词：Several Fluoroquinolones CYP Inhibitors EROD MIDAZOLAM MICROSOMES 
Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats被引量：3
《Acta Pharmacologica Sinica》2019年第8期1106-1118,共13页Kai-jing Zhao Yang Chen Shi-jin Hong Yi-ting Yang Jiong Xu Han-yu Yang Liang Zhu Ming Liu Qiu-shi Xie Xian-ge Tang Ting-ting Yang Ya-qian Zhou Li Liu Xiao-dong Liu 
supported by the National Natural Science Foundation of China (No. 81573490, 81872930, 81473273 and 81673505);Natural Science Foundation of Jiangsu Province of China (BK20161457);the "333", "Six Talent Peaks" and "Cyan Blue" Projects of Jiangsu Province
Cinnamic acid and its analogues (pyragrel and ozagrel) undergo chain-shortened (β-oxidative) and reductive metabolism on acyl side chain. In this study, we characterized the β-oxidative and reductive metabolism on a...
关键词：ANTIPLATELET DRUG cinnamic acid pyragrel OZAGREL DRUG METABOLISM hepatocytes mitochondria MICROSOMES pharmacokinetics in vitro-in vivo correlation 
Identification and interspecies characterization of UDP-glucuronosyltransferase isoforms catalyzing acacetin glucuronidation using recombinant UGT enzymes and microsomes被引量：3
《Journal of Traditional Chinese Medical Sciences》2019年第2期155-163,共9页Kangle Shi Shan Li Qinggang Meng 
the National Natural Science Foundation of China(81473800).
Objective:To explore the glucuronic acid metabolism of acacetin in human liver and intestinal microsomes to better characterize human uridine 5'-diphospho (UDP)-glucuronosyltransferase (UGT) isoforms.In addition,inter...
关键词：ACACETIN UDP-GLUCURONOSYLTRANSFERASES Human liver MICROSOMES GLUCURONIDATION Species differences 
Inhibitory effect of the combination of notoginseng total saponins and safflower total flavonoids on UDP-glucuronosyltransferases 1A1, 1A4, and 2B7 in human liver microsomes被引量：3
《Journal of Chinese Pharmaceutical Sciences》2019年第4期229-237,共9页李岩 孟雨晴 逯颖媛 常坤 高鹏 姜勇 屠鹏飞 郭晓宇 
National Natural Science Foundation of China(Grant No.81573684);National Key Technology R&D Program "New Drug Innovation" of China(Grant No.2018ZX09711001-008-003);Beijing Municipal Science and Technology Project(Grant No.Z181100002218028)
In the present study, the potential inhibition behaviors of notoginseng total saponins(NS), safflower total flavonoids(SF), and their combination(CNS) towards three major isoforms of UDP-glucuronosyltransferases(UGTs)...
关键词：UDP-GLUCURONOSYLTRANSFERASES Human liver MICROSOMES Herb-drug interaction Notoginseng RADIX et Rhizoma Carthami Flos 
Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations(MDO)被引量：3
《Acta Pharmaceutica Sinica B》2017年第2期241-248,共8页Ai-Ming Yu Magnus Ingelman-Sundberg Nathan J.Cherrington Lauren M.Aleksunes Ulrich M.Zanger Wen Xie Hyunyoung Jeong Edward M.Morgan Peter J.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David J.Waxman Li Wang Xiao-bo Zhong 
supported by grants of U01CA175315 and R01GM113888 from the U.S.National Institutes of Health(NIH);supported by grants of ES006694 and ES007091 from NIH;supported by grants of ES021800,ES020522,and ES005022 from NIH;supported by the Robert Bosch Foundation,Stuttgart,Germany;supported by grants of ES023438 and DK083952 from NIH;supported by grant of R01HL122593 from NIH and the Searle Scholars Program,USA;supported by grant of R01ES025708 from NIH;supported by grants of CA098468 and T32DK007737 from NIH;supported by grants of R01DK33765 and R01ES024421 from NIH;supported by grants of R01DK104656,R01DK080440,R01ES025909,R21AA022482,and R21AA024935 from NIH,grant of 1I01BX002634 from VA Merit Award,USA,grant of No.81572443 from National Natural Science Foundation of China,and grant of P30 DK34989 from Yale Liver Center,USA;supported by grants of R01ES019487,R01GM087367,and R01GM118367 from NIH
Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision medicine.At the 21 st International Symposium on Microsomes an...
关键词：Drug metabolism and toxicity Genetics EPIGENETICS Gut microbiota Long non-coding RNAs Disease Personalized medication 
Liver regeneration is associated with lipid reorganization in membranes of the endoplasmic reticulum
《Frontiers in Biology》2016年第5期396-403,共8页Anatoly I. Bozhkov Natalia G. Menzyanova Vadim V. Davydov Natalia I. Kurguzova Vadim I. Sidorov Anastasia S. Vasilieva 
BACKGROUND： In recent years, an adaptive endoplasmic reticulum （ER） stress response has been actively investigated. The ER membrane, isolated from the intact and regenerating liver, may be an appropriate model for ...
关键词：REGENERATION neutral lipids microsomes in vitro 
Effects of duration of phenytoin administration on mRNA expression of cytochrome P450 and P-glycoprotein in the liver and small intestine of rats
《Asian Journal of Pharmaceutical Sciences》2016年第5期662-667,共6页Atsushi Kawase Hiroyuki Tanaka Toru Otori Kenji Matsuyama Masahiro Iwaki 
Phenytoin(5,5-diphenylhydantoin;DPH) induces expression of cytochromes P450(CYPs). Interactions between DPH and tacrolimus suggested that the persistence of CYP induction after discontinuation of DPH is dependent on t...
关键词：PHENYTOIN CYTOCHROMES P450 MICROSOMES mRNA LIVER 
In vitro inhibitory effects of plumbagin,the promising antimalarial candidate,on human cytochrome P450 enzymes被引量：2
《Asian Pacific Journal of Tropical Medicine》2015年第11期894-898,共5页Wiriyaporn Sumsakul Wanna Chaijaroenkul Kesara Na-Bangchang 
the financial support provided by Thammasat University Research Fund under the TU Research Scholar,Contract No 78/2557;Commission on Higher Education,Ministry of Education of Thailand,Office of Higher Education Commission,Thammasat University(Excellence Center in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma),Thammasat University and the Thailand Research Fund through a Royal Golden Jubilee Ph.D.scholarship to Wiriyaporn Sumsakul(Grant no.PHD/0326/2551)
Objective:To investigate the propensity of plumbagin to inhibit the three isoforms of human cytochrome P450(CYP),ie.,CYP1A2,CYP2C19,and CYP3A4 using human liver microsomes in ritro.Methods:Inhibitory effects of plumba...
关键词：Metabolism HUMAN liver MICROSOMES PLUMBAGIN Cytoch 
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