GLUCURONIDATION

作品数：11被引量：9H指数：2
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相关领域：医药卫生更多>>
相关作者：马国蒋华良罗小民陈凯先更多>>
相关机构：复旦大学中国科学院更多>>
相关期刊：《Asian Journal of Andrology》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chemical Research in Chinese Universities》更多>>
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Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity
《Cancer Communications》2022年第11期1212-1216,共5页Nicolas Alejandro Fraunhoffer Analía Meilerman Abuelafia Brice Chanez Martin Bigonnet Odile Gayet Julie Roques Eduardo Chuluyan Nelson Dusetti Juan Iovanna 
supported by the National Cancer Institute(Grants number 2018-078,2019-037, 2018-079),Canceropole Provence-Alpes-Côte d’Azur,Amidex Foundation and the national institute of health and medical research.
Dear Editor,Pancreatic ductal adenocarcinoma(PDAC)treatment is focused on two regimens.The polychemotherapy,FOLFIRINOX(folinic acid,fluorouracil,irinotecan,oxali-platin),is used in patients with good health conditions...
关键词：GEMCITABINE cancer CHEMOTHERAPY 
UDP-glucuronosyltransferases mediate coffee-associated reduction of liver fibrosis in bile duct ligated humanized transgenic UGT1A mice
《Hepatobiliary Surgery and Nutrition》2021年第6期766-781,共16页Steffen Landerer Sandra Kalthoff Christian P.Strassburg 
Background:Coffee consumption has been shown to reduce the risk of liver fibrosis and is capable of inducing human UDP-glucuronosyltransferase(UGT)1A genes.UGT1A enzymes act as indirect antioxidants catalyzing the eli...
关键词：GLUCURONIDATION CHOLESTASIS liver fibrosis COFFEE oxidative stress 
Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified
《Acta Pharmacologica Sinica》2021年第2期311-322,共12页Lu-lu Pan Yong Yang Min Hui Shuo Wang Cui-yun Li Hong Zhang Yan-hua Ding Li Fu Xing-xing Diao Da-fang Zhong 
supported by the National Natural Science Foundation of China(grant nos.81521005 and 81903701);the National Key Research Project of the Chinese Academy of Sciences(grant no.XDA12050306).
Forsythin extracted from Forsythiae Fructus is widely used to treat fever caused by the common cold or influenza in China,Japan and Korea.The present study aimed to analyze the pharmacokinetics,metabolism and excretio...
关键词：FORSYTHIN PHARMACOKINETICS drug metabolism drug excretion SULFATION GLUCURONIDATION organic anion transporter 3 
Identification and interspecies characterization of UDP-glucuronosyltransferase isoforms catalyzing acacetin glucuronidation using recombinant UGT enzymes and microsomes被引量：3
《Journal of Traditional Chinese Medical Sciences》2019年第2期155-163,共9页Kangle Shi Shan Li Qinggang Meng 
the National Natural Science Foundation of China(81473800).
Objective:To explore the glucuronic acid metabolism of acacetin in human liver and intestinal microsomes to better characterize human uridine 5'-diphospho (UDP)-glucuronosyltransferase (UGT) isoforms.In addition,inter...
关键词：ACACETIN UDP-GLUCURONOSYLTRANSFERASES Human liver MICROSOMES GLUCURONIDATION Species differences 
Glucuronidation is the dominating in-vivo metabolism pathway of herbacetin:elucidation of herbacetin pharmacokinetics after intravenous and oral administration in rats
《中国药理学与毒理学杂志》2017年第10期1019-1019,共1页Bei-kang GE Liang ZHAO Te QI Ping-xiang XU Ming XUE 
supported by National Foundation of Natural Sciences of China(81573683 and 81173121)
OBJECTIVE To map a comprehensive metabolic pathway of herbacetin in rats,specifically,to elucidate the biotransformation of herbacetin in vivo and to simultaneously monitor the pharmacokinetic process of both parent d...
关键词：herbacetin PHARMACOKINETICS BIOTRANSFORMATION GLUCURONIDATION hepatic metabolism colonic degradation 
The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants被引量：1
《Acta Pharmacologica Sinica》2017年第8期1184-1194,共11页Zi-zhao YANG Li LI Lu WANG Ling-min YUAN Ming-cheng XU Jing-kai GU Hui-di JIANG Lu-shan YU Su ZENG 
This study was supported by the International：Science ＆ Technology Cooperation Progrcam of China （No 2014DFE30050）; Program for Zhejiang Leading Team of S＆T Innovation Team （No 2011R50014）; Natural Science Foundation of Zhejiang Province （No LQ15H310003）; and Fundamental Research Funds for the Central Universities of China Ministry of Education （No 2016XZZX001-08）.
Uridine diphosphate-glucuronosyltransferase （UGT） 2B7 is expressed mostly in the human liver, lung and kidney and can transfer endogenous glucuronide group into its substrate and impact the pharmacological effects o...
关键词：UGT2B7 single nucleotide polymorphisms DIMERIZATION enzyme kinetics morphine metabolism 
Stereoselective glucuronidation of carvedilol by Chinese liver microsomes
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2007年第10期756-764,共9页YOU Lin-ya, YU Chun-na, XIE Sheng-gu, CHEN Shu-qing, ZENG Su (Department of Drug Metabolism and Pharmaceutical Analysis, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China) 
the National Natural Science Foundation of China (No. 30225047);the Science and Technology Foundation of Zhejiang Province, China (No. 2005C13026)
Objective: To study the stereoselective glucuronidation of carvedilol (CARV) by three Chinese liver microsomes. Methods: The metabolites of CARV were identified by a hydrolysis reaction with β-glucuronidase and HPLC-...
关键词：CARVEDILOL (CARV) DERIVATIZATION STEREOSELECTIVITY Enzyme kinetics CHINESE liver MICROSOMES 
Glucuronidation of Two Novel Metabolites of Benproperine with Trichloroacetimidate Donor
《Chemical Research in Chinese Universities》2006年第4期455-458,共4页LI Yan HARA Osamu MAEBA Isamu ZHONG Da-fang 
Supported by the National Natural Science Foundation of China(No. 39930180)
The glucuronide metabolites of benproperine were synthesized from mono-hydroxylate metabolites of benproperine that were treated with methyl （2,3,4-tri-O-acetyl-1-O-tfichloroacetimidoyl ） -α-D-glucopyranuronate wit...
关键词：GLUCURONIDATION BENPROPERINE METABOLITE Trichloroacetimidate 
Biosynthesis of imipramine glucuronide and characterization of imipramine glucuronidation catalyzed by recombinant UGTIA4被引量：3
《Acta Pharmacologica Sinica》2006年第5期623-628,共6页Ming-rong QIAN Su ZENG 
Project supported by the National Natural Science Foundation of China(No C30100232 and No C30225047).
Aim： To study the profile of imipramine N^＋-glucuronidation using homogenates of recombinant uridine-5＇-dipho sphoglucuronosyltransferase 1 A4 （UGT 1A4） from baculovirus-infected sf9 cells. Methods： Recombinant ...
关键词：IMIPRAMINE GLUCURONIDE uridine-5＇- diphosphoglucuronosyltransferase 1A4 BACULOVIRUS solid-phase extraction 
Stereoselective urinary excretion of S-(-)- and R-(+)-propranolol glucuronide following oral administration of RS-propranolol in Chinese Han subjects被引量：2
《World Journal of Gastroenterology》2005年第12期1822-1824,共3页Lian-Jun Luan 
Supported by the National Natural Science Foundation of China, No. 30225047
AIM: To study the stereoselectivity of phase Ⅱ glucuronidation metabolism of side-chain propranolol in Chinese Han population. METHODS: Sixteen adult Chinese Han volunteers with an average age of 20 years were given ...
关键词：STEREOSELECTIVITY EXCRETION Propranolol enantiomer GLUCURONIDATION 
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