BENPROPERINE

作品数：3被引量：4H指数：1
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相关作者：李岩更多>>
相关机构：沈阳药科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Chemical Research in Chinese Universities》《Burns & Trauma》更多>>
相关基金：国家高技术研究发展计划国家自然科学基金更多>>
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Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis
《Burns & Trauma》2023年第1期709-721,共13页Ruzhen Zhang Sheng Chen Zhifan Yang Ning Zhang Kenan Guo Keyi Lv Zimo Zhou Meijiao Gao Xiancheng Hu Yongping Su Jianming He Fengchao Wang 
supported by the National Natural Science Foundation of China(81872556);Chongqing Academician Program(Basic Research and Frontier Exploration)cstc2018jcyj-yszxX0004.
Background:The rapid turnover of the intestinal epithelium is driven by the proliferation and differentiation of intestinal stem cells(ISCs).The dynamics of the F-actin cytoskeleton are critical for maintaining interc...
关键词：F-ACTIN BENPROPERINE ARPC2 Intestinal stem cell YAP 
Glucuronidation of Two Novel Metabolites of Benproperine with Trichloroacetimidate Donor
《Chemical Research in Chinese Universities》2006年第4期455-458,共4页LI Yan HARA Osamu MAEBA Isamu ZHONG Da-fang 
Supported by the National Natural Science Foundation of China(No. 39930180)
The glucuronide metabolites of benproperine were synthesized from mono-hydroxylate metabolites of benproperine that were treated with methyl （2,3,4-tri-O-acetyl-1-O-tfichloroacetimidoyl ） -α-D-glucopyranuronate wit...
关键词：GLUCURONIDATION BENPROPERINE METABOLITE Trichloroacetimidate 
Identification of some benproperine metabolites in humans and investigation of their antitussive effect被引量：4
《Acta Pharmacologica Sinica》2005年第12期1519-1526,共8页Yan LI Da-fang ZHONG Si-wei CHEN Isamu MAEBA 
Project supported by Grant 2003AA2Z347C of the 863 Program of China.
Aim： To identify 4 unknown metabolites of benproperine （BPE l） in human urine after a po dose, and to investigate the antitussive effect of monohydroxylate metabolites. Methods： The putative metabolite references ...
关键词：BENPROPERINE METABOLISM antitussive agents HYDROXYLATION GLUCURONIDE high performance liquid chromatography mass spectrometry 
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