GLUCURONIDE

作品数：33被引量：58H指数：4
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相关领域：医药卫生更多>>
相关作者：王俊伟王绘军罗敬峰郭亚飞杨晓静更多>>
相关机构：重庆市公安局美国农业部中国药科大学中国医学科学院北京协和医学院更多>>
相关期刊：《Cancer Biology & Medicine》《American Journal of Analytical Chemistry》《中国生物学文摘》《Journal of Life Sciences》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划更多>>
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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor
《Neural Regeneration Research》2025年第3期819-820,共2页Rayudu Gopalakrishna Jennifer Aguilar Emily Lee William J.Mack 
supported by NIH grants, NINDS R21 NS116720 and NINDS/NIA RF1 NS130681 (to RG and WJM)。
The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ...
关键词：RESVERATROL MOLAR dated 
A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin
《Journal of Integrative Medicine》2024年第6期621-636,共16页Xin-yang Liu Wei Xie He-yang Zhou Hui-qing Zhang Yong-sheng Jin 
supported by National Natural Science Foundation of China(No.81573585);the Innovative Practice of Undergraduate Project of Naval Medical University(No.FH2021104)。
Natural product-based antiviral candidates have received significant attention.However,there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug resistance.Baicalein and ...
关键词：BAICALIN BAICALEIN Antiviral effects Influenza virus FLAVIVIRUS Hepatitis B virus Mechanism 
Nonalcoholic steatohepatitis increases plasma retention of sorafenib-glucuronide in a mouse model by altering hepatocyte hopping
《Acta Pharmaceutica Sinica B》2024年第11期4874-4882,共9页Erica Toth Hui Li Kayla Frost Paxton Sample Joseph Jilek Siennah Greenfield Dahea You Danielle Kozlosky Michael Goedken Mary F.Paine Lauren Aleksunes Nathan Cherrington 
by National Institute of General Medical Sciences grant(GM123643,USA);National Institute of Environmental Health Sciences grants(T32ES007148,ES028668,ES006694,and ES007091,USA).
Hepatocyte hopping is the hepatocyte-to-sinusoid-to-hepatocyte shuttling that increases the efficiency of hepatic elimination of xenobiotics. This phenomenon is mediated via efflux of hepatic metabolites by Mrp3 and r...
关键词：Nonalcoholic steatohepatitis Hepatocytehopping SORAFENIB Sorafenibglucuronide Drug disposition ADME Transport Knockoutmouse 
Home Monitoring of Estrone-3-Glucuronide (E1-3G) Levels in Two Different Ovarian Stimulation Protocols: A Pilot Study
《Open Journal of Obstetrics and Gynecology》2024年第10期1640-1656,共17页Iavor K. Vladimirov Desislava Tacheva Evan Gatev Magdalena Rangelova Martin Vladimirov 
Background: Studies have shown a strong correlation between the growth of E2 in serum and estrone-3-glucuronide (E1-3G) in urine during ovarian stimulation. Thus, we developed theoretical models for using urinary E1-3...
关键词：Ovarian Stimulation Monitoring E1-3G Antagonist Protocol PPOS Protocol IVF ART 
A New Protocol for Controlled Ovarian Stimulation Monitoring by Self-Determination of Estrone-3-Glucuronide and Single Ultrasound (COSSESU)
《Open Journal of Obstetrics and Gynecology》2021年第9期1217-1228,共12页Iavor K. Vladimirov Martin Vladimirov Desislava Tacheva 
Background: Answering the question...
关键词：COS Monitoring E3G ESTRADIOL TVUS Telemedicine 
Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer被引量：2
《Cancer Biology & Medicine》2021年第1期155-171,共17页Kaiyuan Wang Jian Wang Ting Liu Wenwen Yu Nan Dong Chen Zhang Wenbin Xia Feng Wei Lili Yang Xiubao Ren 
supported by the Science&Technology Development Fund of Tianjin Education Commission for Higher Education,Tianjin,China(Grant No.2017KJ200)。
Objective:Patients with cancer pain are highly dependent on morphine analgesia,but studies have shown a negative correlation between morphine demand and patient outcomes.The long-term use of morphine may result in abn...
关键词：Non-small cell lung cancer TLR4 PD-L1 morphine-3-glucuronide immune escape 
Relationship between plasma 3-DG levels and critical illness and clinical prognosis in patients with sepsis
《Journal of Hainan Medical University》2019年第12期48-52,共5页Su-Yan Zhang Xu-Dong Han Zhi-Long Cao Jin-Feng Lin 
Objective:To explore the relationship among plasma 3-deoxyglucuronide (3-DG) level, severity of sepsis and clinical prognosis, and to provide references for the assessment of sepsis patients' condition and prognosis.M...
关键词：3-deoxyglucuronide SEPSIS SEVERITY of illness Clinical prognosis 
Free bisphenol A(BPA),BPA-Glucuronide(BPA-G),and total BPA concentrations in maternal serum and urine during pregnancy and umbilical cord blood at delivery被引量：3
《Emerging Contaminants》2019年第1期279-287,共9页Warren G.Foster Cariton Kubwabo Ivana Kosarac Sandra Gregorovich Garima Aryal Kaela Coleman 
The time and commitment of study participants to this project are greatly appreciated.Funding for this project was provided from Health Canada under the Chemicals Management Plan.
While adult exposure to total bisphenol A(BPA)has been well documented,developmental exposure to BPA and fetal exposure to the bioactive form(free BPA)remains poorly defined.Therefore,pregnant women(n?199)between 28 a...
关键词：Bisphenol A Free BPA Conjugated BPA PREGNANCY Exposure Fetal development Cord blood 
Sensitive Analysis and Pharmacokinetic Study of Berberrubine Using LC-MS/MS被引量：2
《Chinese Herbal Medicines》2017年第3期236-249,共14页Yu-qing Zhao Na Yang Fei Fei Run-bin Sun Si-qi Feng Jun He Jing-qiu Huang Yue Xie Ji-ye Aa Guang-ji Wang 
National Natural Science Foundation of the People’s Republic of China(No.81573495,81530098);Key Technology Projects of China"Creation of New Drugs"(No.2015ZX09501001);Project for Jiangsu Province Key Lab of Drug Metabolism and Pharmacokinetics(BM2012012)
Objective To develop a sensitive and reproducible liquid chromatography-tandem mass spectrometry（LC-MS/MS） method to evaluate the pharmacokinetic behavior of berberrubine（BRB） and its glucuronide（BRBG） in rats. ...
关键词：berberrubine berberrubine glucuronide LC-MS/MS pharmacokinetic study ratbiological samples 
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine被引量：11
《Acta Pharmacologica Sinica》2017年第3期351-361,共11页Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG 
Acknowledgements This study was financially supported by the National Natural Science Foundation of China （No_ 81573495, 81530098）, the Key Technology Projects of China ＂Creation of New Drugs＂ （No_ 2015ZX09501001）, the Project for Jiangsu Province Key Lab of Drug Metabolism and Pharmacokinetics （No BM2012012） and the Project of the University Collaborative Innovation Center of Jiangsu Province （Modern Chinese Medicine Center and Biological Medicine Center）.
Berberrubine （BRB） is the primary metabolite of berberine （BBR） that has shown a stronger glucose-lowering effect than BBR in vivo. On the other hand, BRB is quickly and extensively metabolized into berberrubine-9...
关键词：HYPERGLYCEMIA glucose-lowering effect BERBERINE berberrubine GLUCURONIDE （x-glycosidase HFD-induced hyperglycemiamodel of C57BL/6 mice human normal liver cell line 1_-02 PHARMACOKINETICS 
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