UDP-GLUCURONOSYLTRANSFERASES

作品数：7被引量：21H指数：3
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相关领域：医药卫生更多>>
相关作者：屠鹏飞郭晓宇更多>>
相关机构：北京大学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Hepatobiliary Surgery and Nutrition》《Journal of Traditional Chinese Medical Sciences》更多>>
相关基金：国家自然科学基金国家科技支撑计划更多>>
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UDP-glucuronosyltransferases mediate coffee-associated reduction of liver fibrosis in bile duct ligated humanized transgenic UGT1A mice
《Hepatobiliary Surgery and Nutrition》2021年第6期766-781,共16页Steffen Landerer Sandra Kalthoff Christian P.Strassburg 
Background:Coffee consumption has been shown to reduce the risk of liver fibrosis and is capable of inducing human UDP-glucuronosyltransferase(UGT)1A genes.UGT1A enzymes act as indirect antioxidants catalyzing the eli...
关键词：GLUCURONIDATION CHOLESTASIS liver fibrosis COFFEE oxidative stress 
Identification and interspecies characterization of UDP-glucuronosyltransferase isoforms catalyzing acacetin glucuronidation using recombinant UGT enzymes and microsomes被引量：3
《Journal of Traditional Chinese Medical Sciences》2019年第2期155-163,共9页Kangle Shi Shan Li Qinggang Meng 
the National Natural Science Foundation of China(81473800).
Objective:To explore the glucuronic acid metabolism of acacetin in human liver and intestinal microsomes to better characterize human uridine 5'-diphospho (UDP)-glucuronosyltransferase (UGT) isoforms.In addition,inter...
关键词：ACACETIN UDP-GLUCURONOSYLTRANSFERASES Human liver MICROSOMES GLUCURONIDATION Species differences 
Inhibitory effect of the combination of notoginseng total saponins and safflower total flavonoids on UDP-glucuronosyltransferases 1A1, 1A4, and 2B7 in human liver microsomes被引量：3
《Journal of Chinese Pharmaceutical Sciences》2019年第4期229-237,共9页李岩 孟雨晴 逯颖媛 常坤 高鹏 姜勇 屠鹏飞 郭晓宇 
National Natural Science Foundation of China(Grant No.81573684);National Key Technology R&D Program "New Drug Innovation" of China(Grant No.2018ZX09711001-008-003);Beijing Municipal Science and Technology Project(Grant No.Z181100002218028)
In the present study, the potential inhibition behaviors of notoginseng total saponins(NS), safflower total flavonoids(SF), and their combination(CNS) towards three major isoforms of UDP-glucuronosyltransferases(UGTs)...
关键词：UDP-GLUCURONOSYLTRANSFERASES Human liver MICROSOMES Herb-drug interaction Notoginseng RADIX et Rhizoma Carthami Flos 
Inhibitory potential of three Yin-tonification herbal formulas on the activities of human major cytochrome P450 and UDP-glucuronosyltransferases isozymes in vitro
《Journal of Traditional Chinese Medicine》2018年第4期511-522,共12页Seong Eun Jin Hyeun-Kyoo Shin Hyekyung Ha 
the Construction of Scientific Evidences for Herbal Medicine Formulas(K16251) and Evaluation of Herb-Drug Interactions(No.K16252) grant from the Korea Institute of Oriental Medicine(KIOM)
OBJECTIVE:To investigate the influence of Yin-tonification herbal formulas Jaeumganghwa-tang(Ziyin Jianghuo Tang,JEGHT),Ssanghwa-tang(Shuanghe Tang,SHT) and Yukmijihwang-tang(Liuwei Di huang Tang,YMJHT) on the activit...
关键词：Yin reinforcing agents CytochromeP-450 enzyme system Uridine diphosphate gluc-uronic acid TRANSFERASES Herb-drug interactions 
Osthole prevents acetaminophen-induced liver injury in mice被引量：8
《Acta Pharmacologica Sinica》2018年第1期74-84,共11页Yun CAI Wu SUN Xin-xin ZHANG Yan-die LIN Hao CHEN Hao LI 
This study was supported by the National Natural Science Foundation of China （No 81270944 and 81070678） and the Qinglan Project （2014） awarded to Dr Hao LI. Dr Hao LI is an associate fellow at the Collaborative Innovation Center for Cardiovascular Disease Translational Medicine.
Acetaminophen （APAP） overdose leads to severe hepatotoxicity. Osthole, a natural coumarin found in traditional Chinese medicinal herbs, has therapeutic potential in the treatment of various diseases. In this study, ...
关键词：ACETAMINOPHEN HEPATOTOXICITY OSTHOLE oxidative stress inflammatory cytokines UDP-GLUCURONOSYLTRANSFERASES SULFOTRANSFERASES H89 L-buthionine sulfoximine 
Effects of diammonium glycyrrhizinate on hepatic and intestinal UDP-Glucuronosyltransferases in rats: Implication in herb-drug interactions
《Chinese Journal of Natural Medicines》2016年第7期534-540,共7页LI Fei-Yan XIE Hao WENG Lin WANG Hong CAO Li-Juan HAO Hai-Ping WANG Guang-Ji 
supported by the Key Lab of Drug Metabolism and Pharmacokinetics of Jiangsu Province(No.BM2012012)
Glycyrrhizin is a major bioactive component of liquorice, which exerts multiple biochemical and pharmacological activities and is frequently used in combination with other drugs in the clinic. Mycophenolate mofetil(MM...
关键词：Diammonium glycyrrhizinate UDP-GLUCURONOSYLTRANSFERASE SPRAGUE-DAWLEY rat Drug-drug interaction 
Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients被引量：7
《Acta Pharmacologica Sinica》2015年第5期644-650,共7页Xiao-chun XIE Jun LI Hong-yang WANG Hong-liang LI Jing LIU Qian FU Jia-wen HUANG Chen ZHU Guo-ping ZHONG Xue-ding WANG Ping-ping SUN Min HUANG Chang-xi WANG Jia-li LI 
Aim： To evaluate the effects of UDP-glucuronosyltransferases （UGTs） polymorphisms on the pharmacokinetics of the immunosuppressant mycophenolate mofetil （MMF） in Chinese renal transplant recipients. Methods： A t...
关键词：renal transplantation IMMUNOSUPPRESSANT mycophenolate mofetil mycophenolic acid 7-O-MPA-glucuronide PHARMACOKINETICS UDP-GLUCURONOSYLTRANSFERASES genetic polymorphisms 
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