云南高校图书馆联盟文献共享服务平台- UDP-GLUCURONOSYLTRANSFERASE

UDP-GLUCURONOSYLTRANSFERASE: 作品数：17被引量：53H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：吴媛吴媛董瑞华刘泽源更多>>; 相关机构：军事医学科学院杭州师范大学解放军第307医院更多>>; 相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Pharmacology & Pharmacy》更多>>; 相关基金：国家自然科学基金更多>>

Genetics of Gallstone Disease and Their Clinical Significance: A Narrative Review: 《Journal of Clinical and Translational Hepatology》2024年第3期316-326,共11页Christopher J.Costa Minh Thu T.Nguyen Haleh Vaziri George Y.Wu; Gallstone(GS)disease is common and arises from a combination of genetic and environmental factors.Although genetic abnormalities specifically leading to cholesterol GSs are rare,there are clinically significant gene v...; 关键词：GALLSTONES CHOLELITHIASIS ATP-binding cassette transporters ABCG8 protein Human UDP-glucuronosyltransferase A1

真核表达肝药酶UGT1A9可溶重组蛋白方法探索: 《杭州师范大学学报（自然科学版）》2023年第4期351-357,共7页尹鑫俐戚旭丹涂予溪陆茜杨元陈侠斌童骏森; 国家自然科学基金项目(32101010).; UDP-葡萄糖醛酸基转移酶(UGTs)是人体重要的肝脏药物代谢酶,其底物选择性、催化机制等研究因难以获得可溶性全酶而受到限制.本研究以制备UGT1A9可溶重组蛋白为研究目标,通过筛选重组蛋白表达体系、融合标签种类及linker长度,优化重组蛋...; 关键词：药物代谢酶 UDP-GLUCURONOSYLTRANSFERASE UGT1A9 真核表达蛋白纯化

A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living cells and tissues被引量：3: 《Frontiers of Chemical Science and Engineering》2022年第1期103-111,共9页Mingyue Zhu Zhenhao Tian Lingling Jin Xiaokui Huo Chao Wang Jingnan Cui Yan Tian Xiangge Tian Lei Feng; the Natural Science Foundation of Liaoning Province 2020-MS-252;the National Key R&D Program of China(Grant No.2018YFC1603001).; Uridine diphosphate(UDP)-glucuronosyltransferases(UGTs)are enzymes involved in the biotransformation of important endogenous compounds such as steroids,bile acids,and hormones as well as exogenous substances including...; 关键词：UDP-glucuronosyltransferase 1A8 fluorescent probe subtype selectivity fluorescence imaging

Identification and interspecies characterization of UDP-glucuronosyltransferase isoforms catalyzing acacetin glucuronidation using recombinant UGT enzymes and microsomes被引量：3: 《Journal of Traditional Chinese Medical Sciences》2019年第2期155-163,共9页Kangle Shi Shan Li Qinggang Meng; the National Natural Science Foundation of China(81473800).; Objective:To explore the glucuronic acid metabolism of acacetin in human liver and intestinal microsomes to better characterize human uridine 5'-diphospho (UDP)-glucuronosyltransferase (UGT) isoforms.In addition,inter...; 关键词：ACACETIN UDP-GLUCURONOSYLTRANSFERASES Human liver MICROSOMES GLUCURONIDATION Species differences

Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp被引量：1: 《Acta Pharmacologica Sinica》2017年第11期1554-1565,共12页Fan WANG Ming-xing MIAO Bin-bin SUN Zhong-jian WANG Xian-ge TANG Yang CHEN Kai-jing ZHAO Xiao-dong LIU Li LIU; This work was supported by the National Natural Science Foundation of China （No 81373482 and 81573490）, the Natural Science Foundation of Jiangsu Province （No BK20161457） and the ＂Six Talent Peaks＂ Project of Jiangsu Province.; HIV infection is often associated with liver failure, which alters the pharmacokinetics of many drugs. In this study we investigated whether acute liver failure （ALF） altered the pharmacokinetics of the first-line a...; 关键词：ZIDOVUDINE acute liver failure P-GLYCOPROTEIN UDP-glucuronosyltransferase 2B7 PHARMACOKINETICS

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1被引量：7: 《Acta Pharmaceutica Sinica B》2017年第6期657-664,共8页Xuewei Cheng Xia Lv Hengyan Qu Dandan Li Mengmeng Hu Wenzhi Guo Guangbo Ge Ruihua Dong; financially supported by National Natural Science Foundation of China (81403002, 81473181, and 81573501);the First Affiliated Hospital of Zhengzhou University (201613);Innovative Entrepreneurship Program of High-Level Talents in Dalian (2016RQ025); UDP-glucuronosyltransferase 1A1(UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions(DDIs), hyperbilirubinemia and dr...; 关键词：ICOTINIB ERLOTINIB UGT1A1 Inhibitory effects Drug–drug interactions(DDIs)

In Vivo Interaction of Morphine and Diclofenac: 《Pharmacology & Pharmacy》2016年第12期493-503,共11页Yoshiaki Kimura Koki Muryoi Mika Shibata Noriyuki Ozaki Kunizo Arai; The number of studies on possible pharmacokinetic interactions between opioid analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used in combination for the treatment of chronic pain, is ...; 关键词：MORPHINE DICLOFENAC UDP-GLUCURONOSYLTRANSFERASE Von Frey Test

Effects of diammonium glycyrrhizinate on hepatic and intestinal UDP-Glucuronosyltransferases in rats: Implication in herb-drug interactions: 《Chinese Journal of Natural Medicines》2016年第7期534-540,共7页LI Fei-Yan XIE Hao WENG Lin WANG Hong CAO Li-Juan HAO Hai-Ping WANG Guang-Ji; supported by the Key Lab of Drug Metabolism and Pharmacokinetics of Jiangsu Province(No.BM2012012); Glycyrrhizin is a major bioactive component of liquorice, which exerts multiple biochemical and pharmacological activities and is frequently used in combination with other drugs in the clinic. Mycophenolate mofetil(MM...; 关键词：Diammonium glycyrrhizinate UDP-GLUCURONOSYLTRANSFERASE SPRAGUE-DAWLEY rat Drug-drug interaction

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α被引量：2: 《Acta Pharmaceutica Sinica B》2016年第5期504-509,共6页Sung-joon Cho Miaoran Ning Yanyan Zhang Leah H.Rubin Hyunyoung Jeong; supported by the U.S. National Institute of Health (Grants HD065532 and GM112746); UDP-glucuronosyltransferase 1A9(UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules.Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or...; 关键词：UGT1A9 17Β-ESTRADIOL ESTROGEN receptor Drug METABOLISM SEX difference

黄芩素在人及不同种属肝微粒体中的UDP-glucuronosyltransferase代谢差异: 《肿瘤药学》2013年第5期400-400,共1页吴媛董瑞华高欣刘泽源; 目的研究黄芩素在不同种属肝微粒体中的UDP-葡萄糖醛酸转移酶(UDP-glucuronosyltransferase,UDPGA)代谢差异特性。方法使用肝微粒体体外代谢孵育法、HPLC-UV分析方法,选用不同种属的肝微粒体进行黄芩素UDPGA体外代谢研究。结果黄芩素在...; 关键词：黄芩素代谢葡萄糖醛酸结合物 UDP-葡萄糖醛酸转移酶酶动力学

UDP-GLUCURONOSYLTRANSFERASE