云南高校图书馆联盟文献共享服务平台- MORPHINE

MORPHINE: 作品数：294被引量：364H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李锦白洁陈妍李昕秦伯益更多>>; 相关机构：军事医学科学院昆明理工大学哈尔滨医科大学中国科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金河北省自然科学基金更多>>

Randomized, Double Blind, Double-Masked, Parallel-Group Clinical Study to Compare the Effectiveness of Oral Transmucosal Fentanyl 200 µg vs Morphine Hydrochloride 2 mg IV in the Treatment of Postoperative Pain: 《Open Journal of Anesthesiology》2025年第2期48-58,共11页Hernan Figueredo Vicente Bozza Maria Gonzalez Yibirin David Alberto Rincón Matute; Postoperative pain is an acute pain that appears due to the surgical act, reaching its maximum intensity in the first 24 - 48 hours after surgery. Postoperative pain control reduces possible postoperative complication...; 关键词：Postoperative Pain VAS PR PID SPID TOTPAR FENTANYL MORPHINE

Astrocytic pyruvate dehydrogenase kinase-lactic acid axis involvement in glia-neuron crosstalk contributes to morphine-induced hyperalgesia in mice: 《Fundamental Research》2024年第4期820-828,共9页Xiaqing Ma Qi Qi Wenying Wang Min Huang Haiyan Wang Limin Luo Xiaotao Xu Tifei Yuan Haibo Shi Wei Jiang Tao Xu; the National Natural Science Foundation of China(82171486);Natural Science Foundation of Shanghai to T.X.(21ZR1448400);the Interdisciplinary Program of Shanghai Jiao Tong University to T.X.(YG2021ZD23);General Science Foundation of Shanghai Sixth People's Hospital to T.X.(YNMS202114);the Young Scholarship Program of the National Natural Science Foundation of China to Xiaqing Ma(82201366)and by Shanghai Sailing Program(21YF1434200).; The activation of spinal astrocytes accounts for opioid-induced hyperalgesia(OIH),but the underlying mechanisms remain elusive.The presence of astrocyte-neuron lactate shuttle(ANLS)makes astrocytes necessary for some ...; 关键词：Pyruvate dehydrogenase kinase 4 Phosphorylated pyruvate dehydrogenase Astrocyte-neuron lactate shuttle Opioid-induced hyperalgesia LACTATE

PBPK-PD model for predicting morphine pharmacokinetics,CNS effects and naloxone antagonism in humans: 《Acta Pharmacologica Sinica》2024年第8期1752-1764,共13页Rui-jing Mu Tian-lei Liu Xiao-dong Liu Li Liu; supported by the National Key Research and Development Program of China(Grant No.2022YFC3300902).; Morphine and morphine-6-glucuronide(M6G)produce central nervous system(CNS)effects by activating mu-opioid receptors,while naloxone is used mainly for the reversal of opioid overdose,specifically for the fatal complic...; 关键词：MORPHINE NALOXONE PBPK-PD model MIOSIS respiratory depression ANALGESIA

改进鸽群和Morphin算法的混合路径规划算法研究: 《机械设计与制造》2024年第6期53-57,63,共6页支奕琛谷玉海徐小力龙伊娜; 促进高校内涵发展—学科建设专项资助项目(5112011015)。; 针对目前无人车在复杂环境例如同时存在静态和动态障碍物的环境下路径规划能力较弱的情况,提出了一种引入自适应权重系数的鸽群算法和Morphine算法的混合路径规划算法。(1)在栅格地图中确定起点和终点同时建立环境模型;(2)在鸽群算中加...; 关键词：无人车障碍物改进鸽群算法 Morphine算法

Cardiovascular Risk of Opioids: A Real-World Study Based on FAERS: 《Journal of Clinical and Nursing Research》2024年第6期48-57,共10页Yanli Yang Shiliang Xi Heqing Tang; Objective:This research utilizes the FAERS for data mining to identify heart-related side effects caused by opioids,ensuring the safe use of these medications.Methods:Data from 79 quarters(Q12004 to Q32023)involving a...; 关键词：OPIOIDS FAERS Cardiovascular adverse events MORPHINE HYDROMORPHONE OXYCODONE METHADONE TRAMADOL

Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway: 《Genes & Diseases》2024年第3期120-123,共4页Hui Wang Zhonghao Li Qisheng Wang Weixin Lin Ziting Zhou Xinru Mu Yongwei Jiang Shengfeng Lu Shaodong Chen Zhigang Lu; supported by the National Natural Science Foundation of China(No.82174498,82174141);the National Administration of Traditional Chinese Medicine Youth Qihuang Scholars Support Project,the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(China)(No.2020YLXK013);the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(No.KYCX21_1796).; Opioid abuse can suppress the lymphatic system function,and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillinresistant Staphylococcus aureus(MRSA)pneumonia....; 关键词：HERBAL GYPENOSIDES IMMUNOSUPPRESSION

Stereoselective recognition of morphine enantiomers by μ-opioid receptor: 《National Science Review》2024年第3期177-185,共9页Yibo Wang Van A.Ngo Xiaohui Wang; supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0450102);the Scientific and Technological Innovation 2030(STI2030)-Major Projects(2021ZD0203000(2021ZD0203003));the National Natural Science Foundation of China(91956121,22277118 and 21950410528);the Beijing National Laboratory for Molecular Sciences(BNLMS202108);the Chinese Academy of Sciences Pioneer Hundred Talents Program.; Stereospecific recognition of chiral molecules plays a crucial role in biological systems.The μ-opioid receptor(MOR)exhibits binding affinity towards(-)-morphine,a well-established gold standard in pain management,wh...; 关键词：stereoselective recognition thermodynamics and kinetics residence time morphine enantiomers μ-opioid receptor

Postoperative Analgesia and Cesarean Section under General Anesthesia: Multicenter Study: 《Open Journal of Anesthesiology》2024年第1期1-12,共12页Ghislain Edjo Nkilly Raphael Okoue Ondo Pascal Christian Nze Obiang Stéphane Oliveira Jean-Marcel Mandji-Lawson Romain Tchoua; Background: Neuraxial anesthesia with intrathecal morphine is the reference technique in cesarean section anesthesia for the management of postoperative analgesia. If there is a contraindication to this, general anest...; 关键词：CESAREAN General Anesthesia MORPHINE Parietal Infiltration Epidural Catheter Transversus Abdominis Plane Block Intravenous Analgesia

Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis: 《Signal Transduction and Targeted Therapy》2023年第10期4949-4963,共15页Pengju Yan Ningning Li Ming Ma Zhaoli Liu Huicui Yang Jinnan Li Chunlei Wan Shuliu Gao Shuai Li Longtai Zheng John LWaddington Lin Xu Xuechu Zhen; This research was funded by the National Innovation of Science and Technology-2030(Program of Brain Science and Brain-lnspired Intelligence Technology)Grant(2021ZD0204004);the National Natural Science Foundation of China(81973334,81773702)。; Substance use disorder remains a major challenge,with an enduring need to identify and evaluate new,translational targets for effective treatment.Here,we report the upregulation of Hypoxia-inducible factor-1α(HIF-1α...; 关键词：DRUG MORPHINE ANEMIA

Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice被引量：1: 《Journal of Traditional Chinese Medicine》2023年第5期915-924,共10页HAN Shuai MAO Hua JIN Tingting YAN Rubing WANG Ziyi ZHANG Jie SHI Jianwen LIANG Yongxin; Natural Science Foundation of Shandong Province:Mechanism of the Compound Huanglian Decoction Against Morphine Tolerance Based on Network Pharmacology and Microglia M1/M2 Pattern(No.ZR2023MH270)。; OBJECTIVE: To evaluate the effect of berberine on morphine analgesia, tolerance, and hyperalgesia. METHODS: Morphine-induced acute tolerance model: mice received intraperitoneal berberine at doses of 2.5, 5.0, and 10 ...; 关键词：BERBERINE MORPHINE PAIN drug tolerance HYPERALGESIA

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