supported by the National Key Research and Development Program of China(Grant No.2022YFC3300902).
Morphine and morphine-6-glucuronide(M6G)produce central nervous system(CNS)effects by activating mu-opioid receptors,while naloxone is used mainly for the reversal of opioid overdose,specifically for the fatal complic...
The opioid epidemic in the United States continues to take the lives of many individuals, with overdoses continuing to rise every year. Naloxone is an opioid antagonist that is efficacious in temporarily reversing opi...
A 56-year-old man presented to the emergency department after an intentional overdose of oxycodone and ethanol.He was previously opioid-naive with no other medical history.He subsequently developed acute abdominal pai...
Objective: to observe the clinical effect of combining naloxone and nimodipine in patients with severe cerebral infarction. Methods: 68 patients with severe cerebral infarction admitted from January 2019 to December 2...
supported by a grant from the Deputy of Research and Technology,Health Ministry of Iran[Grant no.642];partially by a grant from the Pasteur Institute of Iran。
Objective This study aimed to investigate the effects of Montanide ISA-720 and Naloxone(NLX)in Hepatitis B surface antigen(HBsAg)vaccine formulation on cytokine and long-lasting antibody responses.Methods First,the HB...
the National Natural Science Foundation of China(31760278);NHC Key Laboratory of Drug Addiction Medicine of Kunming Medical University(2020DAMOP-002)。
The relationship between hippocampal electroencephalogram(EEG)power spectrum and the extinction of addiction memory was investigated.Forty KM mice(Kunming mice)that had successfully established morphine(MOR)-condition...
Objective To observe the efficacy of acupuncture combined with naloxone hydrochloride in the treatment of coma after surgery for cerebral hemorrhage and to explore its possible mechanism of action.Methods Seventy-two ...
the financial support received from the Natural Science Foundation of Liaoning Province [No. 20180550155, 2021-MS-332];the National Natural Science Foundation of China (No.81671907, 81871556, 82072165);LiaoNing Revitalization Talents Program (No. XLYC1902108);Scientific Research Project of the Educational Department of Liaoning Province(No. JYTQN201917, JYTQN201919);Liaoning Provincial Key Laboratory of Marine Bioactive Substances and Technological Innovation Center of Liaoning Pharmaceutical Action and Quality Evaluation (No. 2020–10)。
Spinal cord injury(SCI)causes Ca^(2+) overload,which can lead to inflammation and neuronal apoptosis.In this study,we prepared a nanovesicle derived from macrophage membrane(MVs),which encapsulated sodium alginate(SA)...
Objective: the purpose of this project is to explore the strategies and effects of clinical treatment for patients suffering from acute cerebrovascular diseases accompanied by conscious disturbance. Methods: 30 patien...
Spexin/NPQ is a novel highly conserved neuropeptide.It has a widespread expression in the periphery and central nervous system.This study explored the mechanisms and effects of supraspinal spexin on in A ammatory pain...