NIMODIPINE

作品数:75被引量:210H指数:8
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相关领域:医药卫生更多>>
相关作者:曹美鸿陈立华袁贤瑞王磊蔡景霞更多>>
相关机构:中国科学院中国药科大学第三军医大学中国医学科学院北京协和医学院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划天津市自然科学基金更多>>
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UHPLC-MS/MS Approach for Following Nimodipine Saturation Kinetics in Acute Rat Brain Slice
《Journal of Analysis and Testing》2024年第4期466-477,共12页Zahraa Ali Rita Frank Tímea Körmöczi István Ilisz Ferenc Domoki Roland Weiczner Ferenc Bari Eszter Farkas Róbert Berkecz 
supported by National Research,Development,and Innovation Office-NKFIA through projects:“National Laboratory of Translational Neuroscience(NLTN)Neurodevelopmental disorders”,“Adult nervous system disorders”(RRF-2.3.121-2022-00011);KIM NKFIA 2022-2.1.1-NL-2022-00005.Project No.TKP2021-EGA-32,TKP-2021-EGA-05,and K134334 have been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research,Development and Innovation Fund,financed under the TKP2021-EGA funding scheme;Further support was provided by the EU’s Horizon 2020 research and innovation program under grant agreement No.739593。
Nimodipine(NMD)has gained increasing attention in the latest scientific studies as it can act alone or in combination with other drugs to relieve or prevent symptoms of traumatic brain injury,ischemic stroke,and migra...
关键词:NIMODIPINE Brain Electrospray ionization(ESI) UHPLC-MS MS ISCHEMIA 
Observation of the Clinical Effect of Combining Naloxone and Nimodipine in Patients with Severe Cerebral Infarction
《外文科技期刊数据库(文摘版)医药卫生》2022年第10期166-170,共5页HANZhaoqiang 
Objective: to observe the clinical effect of combining naloxone and nimodipine in patients with severe cerebral infarction. Methods: 68 patients with severe cerebral infarction admitted from January 2019 to December 2...
关键词:severe cerebral infarction NALOXONE NIMODIPINE neurological function adverse reactions 
Clinical Efficacy of Shenmai Injection in the Treatment of Cerebral Vasospasm after Ruptured Aneurysm Surgery
《Case Reports in Clinical Medicine》2021年第10期253-263,共11页Tianya Wu Jingxin Fu Xinghuo Jin Qichao Chen Huanming Huang Shiqi Chen Junan Zhou Longbiao Xu 
Objective: To investigate the therapeutic effect of Shenmai Injection on postoperative cerebral vasospasm in patients with ruptured aneurysms. Methods: Seventy patients undergoing cra...
关键词:Shenmai Injection NIMODIPINE Ruptured Aneurysm Aneurysmal Subarachnoid Hemorrhage Cerebral Vasospasm 
Therapeutic Effect of Piracetam Combined with Nimodipine on Acute Primary Cerebral Hemorrhage
《外文科技期刊数据库(文摘版)医药卫生》2021年第7期001-002,共4页HUO Guojin YAN Feiping 
Objective: to analyze the effect of piracetam combined with nimodipine in the treatment of acute primary cerebral hemorrhage. Results: according to the direction of the research topic, the object of this article is 10...
关键词:acute primary cerebral hemorrhage neural function cerebral blood flow 
Modeling the neuro-protection of theaflavic acid from black tea and its synergy with nimodipine via mitochondria apoptotic pathway
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2021年第2期123-135,共13页Dan MU Huaguang QIN Mengjie JIAO Shaogui HUA Tingzhe SUN 
supported by the National Natural Science Foundation of China(Nos.31971185 and 31800316);the Key Projects of Support Program for Outstanding Young Talents in Colleges and Universities of Anhui Province(Nos.gxyq ZD2020031 and gxyq2018034);the Key Project of the Education Department of Anhui Province,China(No.KJ2017A359)。
Ischemic stroke presents a leading cause of mortality and morbidity worldwide.Theaflavic acid(TFA)is a theaflavin isolated from black tea that exerts a potentially neuro-protective effect.However,the dynamic propertie...
关键词:Theaflavic acid(TFA) NIMODIPINE Ischemic stroke APOPTOSIS SYNERGY 
Cooperative effect of polyvinylpyrrolidone and HPMC E5 on dissolution and bioavailability of nimodipine solid dispersions and tablets被引量:1
《Asian Journal of Pharmaceutical Sciences》2019年第6期668-676,共9页Zhisu Sun Huicong Zhang Huiyang He Lingling Sun Xiaorui Zhang Qun Wang Kexin Li Zhonggui He 
Solid dispersion(SD)systems have been extensively used to increase the dissolution and bioavailability of poorly water-soluble drugs.To circumvent the limitations of polyvinylpyrrolidone(PVP)dispersions,HPMC E5 was ap...
关键词:Solid dispersion NIMODIPINE HPMC E5 Fluid-bed BIOAVAILABILITY 
Bioavailability study of nimodipine in rabbit subarachnoid hemorrhage
《Journal of Hainan Medical University》2019年第11期25-27,共3页Guang Yang Xiang-Ying Li Xiong Wang Jing Chen 
Objective:To observe the bioavailability of subcutaneous injection of nimodipine and oral administration of nimodipine in healthy rabbits and rabbits with subarachnoid hemorrhage (SAH), and determine whether subcutane...
关键词:NIMODIPINE SUBCUTANEOUS injection Oral RABBIT SUBARACHNOID hemorrhage BIOAVAILABILITY 
The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial被引量:8
《Science Bulletin》2019年第2期101-107,共7页Huaguang Zheng Yilong Wang Anxin Wang Hao Li David Wang Xingquan Zhao Penglian Wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei Wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang 
supported by the National 11th&12th Five Year S&T Major Projects(2011BAI08B01,2011BAI08B02);the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2013BAI09B03);the Ministry of Science and Technology of China(2012ZX09303-005-001);Beijing Biobank of Cerebral Vascular Disease(D131100005313003)
Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remain...
关键词:NIMODIPINE Acute ISCHEMIC stroke Mild COGNITIVE IMPAIRMENT COGNITIVE DECLINE Prevention 
Hemostatic Therapy for Intracerebral Hemorrhage
《Open Journal of Modern Neurosurgery》2017年第4期121-128,共8页Xingxia Wang Jie Gong Ping Gu Zhibao Zhao Qingwen Jin 
Objective: To reduce the blood pressure and elevate intracranial pressure using nimodipine (Nimotop Intravenous (IV) infusion). Thus, intracerebral hemorrhage was controlled, and the purpose of hemostasis was achieved...
关键词:NIMODIPINE INTRACEREBRAL HEMORRHAGE HYPERTENSION CRANIAL HYPERTENSION 
Protective effect of ginkgo proanthocyanidins against cerebral ischemia/reperfusion injury associated with its antioxidant effects被引量:3
《Neural Regeneration Research》2016年第11期1779-1783,共5页Wang-li Cao Hai-bo Huang Ling Fang Jiang-ning Hu Zhu-ming Jin Ru-wei Wang 
Proanthocyanidins have been shown to effectively protect ischemic neurons, but its mechanism remains poorly understood. Ginkgo proan-thocyanidins (20, 40, 80 mg/kg) were intraperitoneally administered 1, 24, 48 and ...
关键词:nerve regeneration cerebral ischemia/reperfusion injury PROANTHOCYANIDINS NIMODIPINE superoxide dismutase MALONDIALDEHYDE nitric oxide neural regeneration 
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