supported by National Research,Development,and Innovation Office-NKFIA through projects:“National Laboratory of Translational Neuroscience(NLTN)Neurodevelopmental disorders”,“Adult nervous system disorders”(RRF-2.3.121-2022-00011);KIM NKFIA 2022-2.1.1-NL-2022-00005.Project No.TKP2021-EGA-32,TKP-2021-EGA-05,and K134334 have been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research,Development and Innovation Fund,financed under the TKP2021-EGA funding scheme;Further support was provided by the EU’s Horizon 2020 research and innovation program under grant agreement No.739593。
Nimodipine(NMD)has gained increasing attention in the latest scientific studies as it can act alone or in combination with other drugs to relieve or prevent symptoms of traumatic brain injury,ischemic stroke,and migra...
Objective: to observe the clinical effect of combining naloxone and nimodipine in patients with severe cerebral infarction. Methods: 68 patients with severe cerebral infarction admitted from January 2019 to December 2...
Objective: To investigate the therapeutic effect of Shenmai Injection on postoperative cerebral vasospasm in patients with ruptured aneurysms. Methods: Seventy patients undergoing cra...
Objective: to analyze the effect of piracetam combined with nimodipine in the treatment of acute primary cerebral hemorrhage. Results: according to the direction of the research topic, the object of this article is 10...
supported by the National Natural Science Foundation of China(Nos.31971185 and 31800316);the Key Projects of Support Program for Outstanding Young Talents in Colleges and Universities of Anhui Province(Nos.gxyq ZD2020031 and gxyq2018034);the Key Project of the Education Department of Anhui Province,China(No.KJ2017A359)。
Ischemic stroke presents a leading cause of mortality and morbidity worldwide.Theaflavic acid(TFA)is a theaflavin isolated from black tea that exerts a potentially neuro-protective effect.However,the dynamic propertie...
Solid dispersion(SD)systems have been extensively used to increase the dissolution and bioavailability of poorly water-soluble drugs.To circumvent the limitations of polyvinylpyrrolidone(PVP)dispersions,HPMC E5 was ap...
Objective:To observe the bioavailability of subcutaneous injection of nimodipine and oral administration of nimodipine in healthy rabbits and rabbits with subarachnoid hemorrhage (SAH), and determine whether subcutane...
supported by the National 11th&12th Five Year S&T Major Projects(2011BAI08B01,2011BAI08B02);the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2013BAI09B03);the Ministry of Science and Technology of China(2012ZX09303-005-001);Beijing Biobank of Cerebral Vascular Disease(D131100005313003)
Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remain...
Objective: To reduce the blood pressure and elevate intracranial pressure using nimodipine (Nimotop Intravenous (IV) infusion). Thus, intracerebral hemorrhage was controlled, and the purpose of hemostasis was achieved...
Proanthocyanidins have been shown to effectively protect ischemic neurons, but its mechanism remains poorly understood. Ginkgo proan-thocyanidins (20, 40, 80 mg/kg) were intraperitoneally administered 1, 24, 48 and ...