Effects of Different Extinction for Morphine-CPP on Hippocampal EEG Power Spectrum in Mice  

作　　者：LI Chunchun GAO Jingyao WANG Xiaoqin WANG Gongwu CAO Jun 

机构地区：[1]School of Life Sciences,Yunnan Normal University,Kunming 650500,Yunnan,China [2]School of Ecology and Environmental Science,Yunnan University,Kunming 650500,Yunnan,China

出　　处：《Wuhan University Journal of Natural Sciences》2022年第3期265-272,共8页武汉大学学报（自然科学英文版）

基　　金：the National Natural Science Foundation of China(31760278);NHC Key Laboratory of Drug Addiction Medicine of Kunming Medical University(2020DAMOP-002)。

摘　　要：The relationship between hippocampal electroencephalogram(EEG)power spectrum and the extinction of addiction memory was investigated.Forty KM mice(Kunming mice)that had successfully established morphine(MOR)-conditioned place preference(CPP)were divided into four groups:saline-training extinction(SAL-TE),SAL-natural extinction(SAL-NE),MORTE,MOR-NE,for extinction treatment and EEG recording in the dorsal and ventral hippocampus(DH/VH).Results show that the CPP score of MOR-TE significantly decreased and the total,βandγbands power spectrum of MOR-TE was suppressed.Notably,the total power from the VH was more correlated with the extinction method,and the TE total power was always lower than NE in SAL or MOR group.Naloxone enhanced the EEG total power and all bands(DH)orβandγbands(VH)power in the SAL group.However,in the MOR-TE group,onlyβandγbands power in VH increased(P<0.05).The results suggest that TE can promote the extinction of opiate addictive memory more effectively than NE,and the extinction of MOR-CPP may have a stronger correlation with changes of VH-EEG power spectrum.

关 键 词：MORPHINE NALOXONE conditioned place preference hippocampus electroencephalogram(EEG)power spectrum 

分 类 号：Q42[生物学—神经生物学] R338[生物学—生理学]