Central spexin produces antinociceptive effect against inflammatory pain via Fos in mice  

作　　者：Lyu Shuangyu Cui Binbin Zhang Xiaomei Zhou Yuchen 

机构地区：[1]School of Basic Medical Sciences,Henan Unirversity,Kaifeng 475004,China

出　　处：《解剖学杂志》2021年第S01期78-78,共1页Chinese Journal of Anatomy

摘　　要：Spexin/NPQ is a novel highly conserved neuropeptide.It has a widespread expression in the periphery and central nervous system.This study explored the mechanisms and effects of supraspinal spexin on in A ammatory pain.The results from the mouse formalin test show that i.c.v.administration of spexin decreased licking/biting time during the late and early phases.The nonamidated spexin had no effect on pain response.The antinociception of spexin was blocked by galanin receptor 3 antagonist SNAP37889.The Galr3 and Adcy4 mRNA levels in the brain were increased after injection with spexin.The antinociceptive effects of spexin were completely reversed by opioid receptor antagonist naloxone and kappa-opioid receptor antagonist nor-BNI.

关 键 词：PAIN NALOXONE ANTAGONIST 

分 类 号：R73[医药卫生—肿瘤]