Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway  

作　　者：Hui Wang Zhonghao Li Qisheng Wang Weixin Lin Ziting Zhou Xinru Mu Yongwei Jiang Shengfeng Lu Shaodong Chen Zhigang Lu 

机构地区：[1]Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China [2]Key Laboratory of Acupuncture and Medicine Research of Ministry of Education,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China [3]College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China [4]School of Medicine,Xiamen University,Xiamen,Fujian 361102,China

出　　处：《Genes & Diseases》2024年第3期120-123,共4页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82174498,82174141);the National Administration of Traditional Chinese Medicine Youth Qihuang Scholars Support Project,the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(China)(No.2020YLXK013);the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(No.KYCX21_1796).

摘　　要：Opioid abuse can suppress the lymphatic system function,and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillinresistant Staphylococcus aureus(MRSA)pneumonia.^(1,2)Gypenosides(Gps)are the most important immunomodulator components in the Chinese herbal medicine Gynostemma pentaphyllum.

关 键 词：HERBAL GYPENOSIDES IMMUNOSUPPRESSION 

分 类 号：R392[医药卫生—免疫学]