BACKGROUND Icotinib could have potential effect and tolerability when used sequentially with chemotherapy for advanced epidermal growth factor receptor(EGFR)-mutated non-small cell lung cancer(NSCLC).AIM To evaluate t...
A patient with advanced lung adenocarcinoma who was unable to tolerate chemotherapy was controlled after combined treatment with apatinib.This case provides a basis for the treatment of this disease using this method....
BACKGROUND Epidermal growth factor receptor(EGFR)tyrosine-kinase inhibitors are widely used for the treatment of non-small-cell lung cancer with EGFR mutations.However,patients with rare,even compound EGFR mutations h...
Supported by the Key Project of Nanjing Health Bureau,No.ZKX16031;the Healthcare Project of Nanjing Science and Technology Committee,No.201715020;the Medical Key Science and Technology Development Project of Nanjing,No.ZKX18014;the Cadre Health Care Project of Jiangsu Province,No.BJ18006;the Cancer Research Funding of CSCO-Hausen,No.Y-HS2019-5
BACKGROUND Central nervous system(CNS) metastases are a catastrophic complication of nonsmall cell lung cancer(NSCLC), including brain and leptomeningeal carcinomatosis, and are always accompanied by a poor prognosis....
Objective To provide theoretical basis for clinical treatment of patients with terminal non-small cell lung cancer through the analysis of the cost and adverse reactions of the joint treatment of icotinib and pemetrex...
A 61-year-old Chinese woman was diagnosed as primary pulmonary adenocarcinoma of left superior lobe with epidermal growth factor receptor(EGFR)19 del mutation positive.Treatment with icotinib was given,but her disease...
To the Editor:A 66-year-old woman presented with a severe cough and was admitted into hospital in April 2014.Positron emission tomography/computed tomography (PET/CT) scan showed a 2.0 cm×2.0 cm node located on the l...
Surgery is the first choice of treatment for patients with non-small-cell lung cancer(NSCLC), but few patients can be treated surgically because of either advanced disease or poor pulmonary function. Other therapies i...
financially supported by National Natural Science Foundation of China (81403002, 81473181, and 81573501);the First Affiliated Hospital of Zhengzhou University (201613);Innovative Entrepreneurship Program of High-Level Talents in Dalian (2016RQ025)
UDP-glucuronosyltransferase 1A1(UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions(DDIs), hyperbilirubinemia and dr...
Objective Treatment of brain metastases from non-small cell lung cancer(NSCLC) is a challenge because of the poor prognosis. Icotinib is a new type of oral epidermal growth factor receptor(EGFR) tyrosine kinase inhibi...