PEMETREXED

作品数：58被引量：75H指数：5
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相关领域：医药卫生更多>>
相关作者：袁芃施春雷徐兵河廖美琳朱利明更多>>
相关机构：中山医学大学阿斯利康(瑞典)有限公司上海市胸科医院中国医学科学院肿瘤医院更多>>
相关期刊：《药学进展》《Asian Journal of Social Pharmacy》《Science China Chemistry》《Oncology and Translational Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金天津市自然科学基金更多>>
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Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer
《Chinese Chemical Letters》2024年第12期228-233,共6页Zhi Li Shuya Pan Yuan Tian Shaowei Liu Weifeng Wei Jinlin Wang Tianfeng Chen Ling Wang 
supported by National Natural Science Foundation for Distinguished Young Scholars(No.82225025);National Natural Science Foundation of China(Nos.21877049,32171296)。
Selenium(Se)plays an important role in the development and treatment of lung cancer,yet its specific mechanisms remain elusive.Lower Se level in serum was noted in lung cancer patients compared to normal controls.Ther...
关键词：Selenium nanoparticles LENTINAN CHEMOTHERAPY PEMETREXED Non-small cell lung cancer Apoptosis 
Overcoming immuno-resistance by rescheduling anti-VEGF/cytotoxics/anti-PD-1 combination in lung cancer model
《Cancer Drug Resistance》2024年第1期910-924,共15页Guillaume Sicard Dorian Protzenko Sarah Giacometti Fabrice Barlési Joseph Ciccolini Raphaelle Fanciullino 
supported by A^(*)midex Foundation-initiative d’Excellence and the Aix-Marseille Université。
Background:Many tumors are refractory to immune checkpoint inhibitors,but their combination with cytotoxics is expected to improve sensitivity.Understanding how and when cytotoxics best re-stimulate tumor immunity cou...
关键词：Immune checkpoint inhibitors CISPLATIN PEMETREXED ANTI-VEGF non-small cell lung cancer efficacy study immunomonitoring 
Successful re-challenge of PD-1 inhibitors in combination with bevacizumab and pemetrexed for multiple primary NSCLC progressing on prior PD-1 inhibitor therapy:one case report
《Drug Combination Therapy》2023年第3期9-13,共5页Sheng-Hong Wu Mei Wang Ying Zhu Zhong-Hui He 
Lung cancer is a malignant tumor with high incidence and mortality rates in China and worldwide.Approximately 10%of these diseases are caused by multiple primary non-small cell lung cancers(NSCLC).Traditional antitumo...
关键词：NSCLC brain metastases PD-1 inhibitor BEVACIZUMAB PEMETREXED side effect 
Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell lung cancer:a retrospective analysis被引量：1
《Frontiers of Medicine》2022年第4期610-617,共8页Yaru Tian Hairong Tian Xiaoyang Zhai Hui Zhu Jinming Yu 
supported by the National Key R&D Program of China(No.2018YFC1313201);the Innovation Project of Shandong Academy of Medical Sciences(No.2019-04);the Academic Promotion Program of Shandong First Medical University(No.2019ZL002).
Bevacizumab,an anti-VEGF monoclonal antibody,has significantly improved the clinical outcomes of patients with advanced non-squamous NSCLC(ns-NSCLC).However,the safety and efficacy of bevacizumab for elderly patients ...
关键词：BEVACIZUMAB elderly patient advanced non-small-cell lung cancer overall survival toxicity 
Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial被引量：2
《Cancer Biology & Medicine》2022年第7期1089-1099,共11页Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang 
supported by grants from the National Natural Science Foundation of China(Grant No.81970184),The National Science and Technology Major Project of China(Grant No.2020ZX09201-009);Henan Medical Science and Technology Tacking Program(Joint Project)(Grant No.LHGJ20190021)。
Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary ce...
关键词：RITUXIMAB primary central nervous system lymphoma PEMETREXED FOTEMUSTINE WBRT 
Cost-Effectiveness Analysis of Atezolizumab plus Pemetrexed and Platinum in First-Line Treatment of Non-Squamous Non-Small Cell Lung Cancer in China
《Pharmacology & Pharmacy》2022年第6期164-173,共10页Wenyue Wang Yongfa Chen 
Objective: To evaluate the cost-effectiveness of atezolizumab plus pemetrexed and platinum-based (APP) in the first-line treatment of non-squamous non- small cell lung cancer (NSCLC). Methods: A partitioned survival m...
关键词：Atezolizumab Non-Small Cell Lung Cancer Partitioned Survival Model Cost-Effectiveness Analysis 
Dramatic response to immunotherapy in an epidermal growth factor receptor-mutant non-small cell lung cancer: A case report
《World Journal of Clinical Cases》2021年第36期11419-11424,共6页Ding Li Cheng Cheng Wen-Ping Song Pei-Zan Ni Wen-Zhou Zhang Xuan Wu 
Henan Provincial Science and Technology Research Project,No.202102310157;Medical Science and Technology Research Plan(Joint Construction)Project of Henan Province,No.LHGJ20190676.
BACKGROUND The advent of immune checkpoint inhibitors(ICIs)has revolutionized the management of several types of solid cancers,including lung cancer,by boosting the body's natural tumor killing response.However,it is ...
关键词：Epidermal growth factor receptor mutation Non-small cell lung cancer PEMETREXED IMMUNOTHERAPY Case report 
Host-guest inclusion for enhancing anticancer activity of pemetrexed against lung carcinoma and decreasing cytotoxicity to normal cells
《Chinese Chemical Letters》2021年第10期3034-3038,共5页Junyi Chen Yahan Zhang Yadan Zhang Liang Zhao Longming Chen Yao Chai Zhao Meng Xueshun Jia Qingbin Meng Chunju Li 
the National Natural Science Foundation of China(Nos.21772118,21971192,81573354);the Natural Science Foundation of Tianjin City(No.20JCZDJC00200)。
Advanced chemotherapy strategies are in urgent demand for improving anticancer efficacy.Herein,a water-soluble pillar[6]arene(WP6 A)was used to load chemotherapeutic agent pemetrexed(PMX)by forming direct host-guest i...
关键词：Supramolecular chemotherapy Host-guest complexation PEMETREXED ATP Competitive binding 
Rechallenge pemetrexed-based chemotherapy provides an option for initially benefited patients with advanced lung adenocarcinoma
《Chinese Medical Journal》2021年第17期2119-2121,共3页Jia-Ni Wang Quan-Hui Qiao Xing-Sheng Hu Yu-Tao Liu Zhi-Jie Wang Jian-Chun Duan Yu Feng Hao-Hua Zhu 
To the Editor:Pemetrexed plus platinum(cisplatin or carboplatin)chemotherapy doublets are widely recommended as the standard first-line treatment for non-small cell lung cancer(NSCLC)with no identified genetic mutatio...
关键词：CHEMOTHERAPY PEMETREXED ADENOCARCINOMA 
Antitumor and vascular effects of apatinib combined with chemotherapy in mice with non-small-cell lung cancer被引量：1
《Oncology and Translational Medicine》2021年第3期141-147,共7页Hui Cao Shili Wang Yaohui Liu 
Objective The aim of this study was to investigate the antitumor and vascular effects of apatinib use combined with chemotherapy on mice with non-small-cell lung cancer(NSCLC).Methods First,60 tumor-bearing nude mice ...
关键词：non-small-cell lung cancer(NSCLC) apatinib PEMETREXED 
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