A biologic drug is a medication produced from or containing components of living organisms.Given the rigorous testing that originator biologics undergo to establish Food and Drug Administration(FDA)Biologics License A...
funded by Capital Clinical Diagnosis and Treatment Technology Research and Demonstration Application Project of China(Grant No.Z191100006619029);National Key R&D Program of China(Grant No.2020YFC2008200).
Background:To compare the efficacy and safety of preoperative intravitreal injections of ranibizumab and conbercept in Chinese proliferative diabetic retinopathy(PDR)patients.Methods:This prospective randomized contro...
This paper raises the question if intravitreal dexamethasone implant deserves to be utilized more effectively in a select subset of eyes with diabetic macular edema (DME). If so, what is the OCT morphology of such eye...
supported by Frontier Project of Hospital Development Center(SHDC12016105);Clinical Research Innovation Team Project of Shanghai General Hospital(CTCCR-2016A02);Scientific Project of Shanghai Municipal Health Commission(201940151);Shanghai Collaborative Innovation Center for Translational Medicine(TM201917);Shanghai Hospital Development Center(SHDC2020CR2040B and SHDC2020CR5014).
Background To evaluate whether the specific choroidal neovascularization(CNV)characteristics measured using optical coherence tomography angiography(OCTA)can predict the 6-month prognosis of neovascular age-related ma...
supported by grants from the National Natural Science Foundation of China(Grant Nos.82101150,82171078);Shanghai clinical 3-year action plan-major clinical research(Grant Nos.SHDC2020CR2041B,SHDC2020CR5014-003);Shanghai Sailing Program(Grant No.21YF1405300);Shanghai Committee of Science and Technology(Grant Nos.20Y11911100,18411965100).
Background:The aim of the study was to investigate the changes in the periarterial capillary-free zone(paCFZ)after anti-vascular endothelial growth factor(VEGF)therapy in patients with branch retinal vein occlusion(BR...
supported by an unrestricted grant from Research to Prevent Blindness,New York,NY.
Aims:To identify incident macular atrophy and evaluate antecedent anatomic alterations in eyes with neovascular age-related macular degeneration(NVAMD)that were treated with anti-vascular endothelial growth factor(ant...
supported by A^(*)midex Foundation-initiative d’Excellence and the Aix-Marseille Université。
Background:Many tumors are refractory to immune checkpoint inhibitors,but their combination with cytotoxics is expected to improve sensitivity.Understanding how and when cytotoxics best re-stimulate tumor immunity cou...
AIM:To evaluate the efficacy of retinal laser photocoagulation and intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF)for hemorrhagic retinal arterial macroaneurysm(RAM).METHODS:This was a ret...
AIM:To assess the long-term outcomes of treating macular edema(ME)associated with central retinal vein occlusion(CRVO)with a regimen of“5+pro re nata(PRN)”.METHODS:This retrospective study included 27 eyes of 27 pat...