Wide‑field swept‑source OCT angiography of the periarterial capillary‑free zone before and after anti‑VEGF therapy for branch retinal vein occlusion  

作　　者：Wenyi Tang Wei Liu Jingli Guo Lili Zhang Gezhi Xu Keyan Wang Qing Chang 

机构地区：[1]Department of Ophthalmology,Eye and ENT Hospital of Fudan University,83 Fenyang Road,Shanghai 200031,China [2]Shanghai Key Laboratory of Visual Impairment and Restoration,Fudan University,Shanghai,China [3]NHC Key Laboratory of Myopia(Fudan University),Laboratory of Myopia,Chinese Academy of Medical Sciences,Shanghai,China

出　　处：《Eye and Vision》2024年第2期31-40,共10页眼视光学杂志（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(Grant Nos.82101150,82171078);Shanghai clinical 3-year action plan-major clinical research(Grant Nos.SHDC2020CR2041B,SHDC2020CR5014-003);Shanghai Sailing Program(Grant No.21YF1405300);Shanghai Committee of Science and Technology(Grant Nos.20Y11911100,18411965100).

摘　　要：Background:The aim of the study was to investigate the changes in the periarterial capillary-free zone(paCFZ)after anti-vascular endothelial growth factor(VEGF)therapy in patients with branch retinal vein occlusion(BRVO)by widefield swept-source optical coherence tomography angiography(SS-OCTA)and assess their associations with clinical outcomes.Methods:In this retrospective observational study of 54 treatment-naive BRVO patients with macular edema,we reviewed the findings of 12×12 mm^(2)SS-OCTA at baseline,3,6,and 12 months after intravitreal ranibizumab injections.The paCFZ and major retinal artery areas were measured on SS-OCTA images.The paCFZ area to artery area(P/A)ratio was calculated.Results:The paCFZ areas and P/A ratios of first-and second-order arteries were significantly greater in BRVO eyes than in contralateral eyes(all P<0.01),but there were no differences in the first-and second-order artery areas(P=0.20 and 0.25,respectively).The paCFZ areas and P/A ratios decreased significantly at 3,6,and 12 months after anti-VEGF therapy(all P<0.01).The baseline P/A ratio was significantly correlated with the baseline best-corrected visual acuity(BCVA),central retinal thickness,and their improvements at 3,6,and 12 months(all P<0.05).Baseline BCVA and P/A ratios of first-and second-order arteries were independently associated with the final BCVA in multivariate linear regression.Conclusions:Wide-field SS-OCTA shows that anti-VEGF therapy can lead to a significant improvement in the paCFZ parameters in BRVO.Smaller baseline P/A ratios on SS-OCTA tend to predict better visual outcomes at 12 months after anti-VEGF therapy.

关 键 词：Swept-source optical coherence tomography angiography Branch retinal vein occlusion Periarterial capillary free zone Anti-VEGF treatment PROGNOSIS 

分 类 号：R774.1[医药卫生—眼科]