ZIDOVUDINE

作品数：18被引量：28H指数：4
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相关领域：医药卫生更多>>
相关作者：王群更多>>
相关机构：山东农业大学更多>>
相关期刊：《Open Journal of Stomatology》《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》《Advances in Infectious Diseases》更多>>
相关基金：国家自然科学基金更多>>
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Bile duct ligation enhances AZT CNS toxicity partly by impairing the expression and function of BCRP in rat brain被引量：4
《Acta Pharmacologica Sinica》2020年第2期181-191,共11页Yuan-yuan Qin Ping Xu Tong Wu Chao-qun Qian Yi-lin Fan Dong-hao Gen Liang Zhu Wei-min Kong Han-yu Yang Feng Xu Yi-ting Yang Li Liu Xiao-dong Liu 
the National Natural Science Foundation of China(Nos.81573490,81872930,and 81673505);the Natural Science Foundation of Jiangsu Province(BK20161457);the"Double First-Class"University Project(CPU2018GY22).
Breast cancer resistance protein(BCRP)is one of ATP-binding cassette(ABC)transporters in brain microvessel endothelial cells that transport their substrates from brain to blood,thus limiting substrates to crossing int...
关键词：ZIDOVUDINE liver failure breast cancer resistance protein blood-brain barrier PHARMACOKINETICS drug distribution NEUROTOXICITY cognitive functions 
Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp被引量：1
《Acta Pharmacologica Sinica》2017年第11期1554-1565,共12页Fan WANG Ming-xing MIAO Bin-bin SUN Zhong-jian WANG Xian-ge TANG Yang CHEN Kai-jing ZHAO Xiao-dong LIU Li LIU 
This work was supported by the National Natural Science Foundation of China （No 81373482 and 81573490）, the Natural Science Foundation of Jiangsu Province （No BK20161457） and the ＂Six Talent Peaks＂ Project of Jiangsu Province.
HIV infection is often associated with liver failure, which alters the pharmacokinetics of many drugs. In this study we investigated whether acute liver failure （ALF） altered the pharmacokinetics of the first-line a...
关键词：ZIDOVUDINE acute liver failure P-GLYCOPROTEIN UDP-glucuronosyltransferase 2B7 PHARMACOKINETICS 
A stability-indicating LC–MS/MS method for zidovudine: Identification,characterization and toxicity prediction of two major acid degradation products
《Journal of Pharmaceutical Analysis》2017年第4期231-236,共6页Prashant S.Devrukhakar M.Shiva Shankar G.Shankar R.Srinivas 
Zidvovudine(AZT) is a nucleoside analogue reverse transcriptase inhibitor(NRTI), a class of anti-retroviral drug. A stability-indicating assay method for AZT was developed in line with ICH guideline. Successful separa...
关键词：Zidvovudine Stability study DEGRADATION products IN-SILICO TOXICITY prediction LC–ESI/MS/MS DEGRADATION pathway 
Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low-to middle-income countries被引量：1
《Infectious Diseases of Poverty》2017年第1期1449-1461,共13页Richard M.Gibson Gabrielle Nickel Michael Crawford Fred Kyeyune Colin Venner Immaculate Nankya Eva Nabulime Emmanuel Ndashimye Art F.Y.Poon Robert A.Salata Cissy Kityo Peter Mugyenyi Miguel E.Quinones-Mateu Eric J.Arts 
F.K.was funded by a scholarship from the NIH Fogarty International Center grants D43-TW000011 and D43-TW009780.E.J.A.was funded by NIAID/NIH AI49170;holds the Canada Research Chair in HIV-1 Pathogenesis and Viral Control.M.E.Q-M was partially supported by the CWRU/UH Center for AIDS Research(P30 AI036219);by funding from University Hospitals Cleveland Medical Center(UHCMC)for the University Hospitals Translational Laboratory(UHTL).
Background:Thymidine analogs,namely AZT(Zidovudine or Retrovir^(TM))and d4T(Stavudine or Zerit^(TM))are antiretroviral drugs still employed in over 75%of first line combination antiretroviral therapy(cART)in Kampala,U...
关键词：Antiretroviral treatment Drug resistance Uganda 
Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites被引量：1
《Acta Pharmaceutica Sinica B》2016年第2期158-162,共5页Lingli Mu Rui Zhou Fang Tang Xingling Liu Sanwang Li Feifan Xie Xiang Xie Jie Peng Peng Yu 
supported by the National Natural Science Foundation of China (Beijing, China) for Project No. 81102499;the Fundamental Research Funds for the Central Universities of Central South University (No. 2015zzts286)
Zidovudine (AZT), the first drug approved by the US Food and Drug Administration for the treatment of human immunodeficiency virus (HIV) infection, is metabolized in the host cells to 5'-AZT triphosphate (AZT-TP) whic...
关键词：LC-MS/MS ZIDOVUDINE METABOLITES PHOSPHATES hPBMCs hPBMCs PHARMACOKINETICS Intracellular killed 
A Time to Event Analysis of Adverse Drug Reactions Due to Tenofovir, Zidovudine and Stavudine in a Cohort of Patients Receiving Antiretroviral Treatment at an Outpatient Clinic in Zimbabwe
《Pharmacology & Pharmacy》2015年第3期201-206,共6页Tinashe Mudzviti Nyasha T. Mudzongo Samuel Gavi Cleophas Chimbetete Charles C. Maponga Gene D. Morse 
Background: Achieving the long terms goals of antiretroviral treatment (ART) requires a careful approach during treatment initiation that takes into account patient’s psychosocial state, availability and accessibilit...
关键词：Survival ANALYSIS Electronic Medical Records ADVERSE Drug Reactions 
Side effects and tolerability of post-exposure prophylaxis with zidovudine, lamivudine, and lopinavir/ritonavir： a comparative study with HIV/AIDS patients被引量：10
《Chinese Medical Journal》2014年第14期2632-2636,共5页Cai Juan Xiao Jiang Zhang Qiang 
Background In the era of highly active antiretroviral therapy （HAART）, the use of antiretrovirals as post-exposure prophylaxis （PEP） was the most important strategy for preventing occupational exposure to blood or...
关键词：post-exposure prophylaxis HIV/AIDS highly active antiretroviral therapy side effect 
An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings： a prospective, multicenter study in China被引量：7
《Chinese Medical Journal》2014年第1期59-65,共7页Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg 
Background An zidovudine （AZT）-substitution regimen containing 24-week stavudine （d4T） followed by long-term AZT for HIV therapy is potential to trade off short-term AZT-related anemia and long-term risks associat...
关键词：human immunodeficiency virus acquired immunodeficiency syndrome antiretroviral therapy ZIDOVUDINE STAVUDINE anemia LIPODYSTROPHY 
Trizivir (Abacavir/Lamivudine/Zidovudine) plus Lopinavir/Ritonavir Induction Therapy Followed by Trizivir-Alone Maintenance for HIV-1-Infected Patients: A 96-Week Pilot Treatment Simplification Study
《World Journal of AIDS》2012年第3期245-251,共7页Joseph C. Gathe Dean T. Martin M. Keith Rawlings Benjamin Daquioag John E. Fuchs Vanessa C. Williams Katrina L. Oie Gary E. Pakes 
Objective: The purpose of this study was to investigate whether switching HIV-infected patients stabilized on Trizivir (abacavir 300 mg/lamivudine 150 mg/zidovudine 300 mg) plus lopinavir/ritonavir 400 mg/100mg twice ...
关键词：Abacavir/Lamivudine/Zidovudine HIV-1 Infection Induction-Maintenance Strategy KALETRA Lopinavir/Ritonavir Trizivir 
Steady-state pharmacokinetics of zidovudine in Chinese HIV-infected patients被引量：4
《Chinese Medical Journal》2012年第11期1931-1935,共5页LIU Li-feng WANG Lu FU Qiang ZHU Zhu XIE Jing HAN Yang LIU Zheng-yin YE Min LI Tai-sheng 
This study was supported by the grants from the National Key Technologies R＆D Program for the llth Five-year Plan （No. 2008ZX10001-006） and the National Natural Science Foundation of China （No. 81071372）.
Background The pharmacokinetics of zidovudine （AZT） are possibly influenced by weight, age, sex, liver and renal functions, severity of disease, and ethnicity. Currently, little information is available on the stead...
关键词：human immunodeficiency virus  steady-state PHARMACOKINETICS ZIDOVUDINE Chinesepatients 
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