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Chrysophanol Induces Cell Death and Inhibits Invasiveness through Alteration of Calcium Levels in HepG2 Human Liver Cancer Cells
《Chinese Journal of Integrative Medicine》2025年第5期434-440,共7页CHEN Shu-chao CHEN Qiao-wen KO Chih-yuan 
Supported by Academic Funding from the Second Affiliated Hospital of Fujian Medical University(Serial No.BS201902);Quanzhou Science and Technology Project(No.2020N090S,the Malignant Tumor Clinical Medicine Research Center,Quanzhou City,Fujian Province,China)。
Objective:To investigate the effect of chrysophanol,a phytochemical derived from Radix et Rhizoma Rhei on HepG2 liver cancer cells.Methods:HepG2 cell line was treated with different concentrations chrysophanol(0-100μ...
关键词:apoptosis calcium CHRYSOPHANOL liver cancer mitochondrial membrane potential Radix et Rhizoma Rhei Chinese medicine 
Assembly and network of Rhei Radix et Rhizoma surface microbiome shaped by processing methods and sampling locations
《Chinese Herbal Medicines》2025年第1期189-199,共11页Guangfei Wei Xiao Chen Guozhuang Zhang Conglian Liang Zhaoyu Zhang Bo Zhang Shilin Chen Linlin Dong 
supported by grants from the National Key R&D Plan(No.2022YFC3501801,2022YFC3501802and 2022YFC3501804);Fundamental Research Funds for the Central Public Welfare Research Institutes(No.ZXKT21037,ZZ15-YQ044,ZXKT22050 and ZXKT22001);Scientific Research Project of Hainan Academician Innovation Platform(No.YSPTZX202137 and SQ2021PTZ0052);Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2023E002-Y-58)。
Objective:Rhei Radix et Rhizoma has five types of products,namely,raw rhubarb(RR),wine rhubarb(WR),vinegar rhubarb(VR),cooked rhubarb(CR),and rhubarb charcoal(RC).However,Rhei Radix et Rhizoma is easily contaminated w...
关键词:community assembly FUNGI processing methods Rhei Radixet Rhizoma sampling locations 
Chinese medicine Bupleuri Radix inhibits the proliferation of renal clear cell carcinoma is related to RORC
《Integrative Medicine Discovery》2025年第5期1-12,共12页Yan Li Hao-Yu Wang An-Qi Lv Xun Xu Wei Yan Lang Guo Zhong-Min Zhang Bing-Qi Zhang Zheng-Ming Liao 
supported by Hubei Provincial Department of Science and Technology,Innovation and Development Joint Fund(No.2022CFD145);Young Talents Project of Hubei Provincial Administration of Traditional Chinese Medicine(No.ZY2023Q002).
Background:This research aims to investigate potential gene targets and mechanisms through which the traditional Chinese medicine(TCM)Bupleuri Radix(Chaihu)may impact on clear cell renal cell carcinoma(ccRCC)treatment...
关键词:traditional Chinese medicine Bupleuri Radix(Chaihu) clear cell renal cell carcinoma urologic neoplasms RORC(RORγ) 
Astragali Radix-Notoginseng Radix et Rhizoma medicine pair prevents cardiac remodeling by improving mitochondrial dynamic balance
《Chinese Journal of Natural Medicines》2025年第1期54-63,共10页Pingping Lin Hong Chen Zekun Cui Boyang Yu Junping Kou Fang Li 
supported by the National Natural Science Foundation of China (Nos. 82274231 and 81973506);the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No.CMEMR2023-B12);the Fundamental Research Funds for the Central Universities (No. 2632023TD06);the Young Talent Support Project of Jiangsu Association for Science and Technology(No. TJ-2022-025);the Qinglan Project of Jiangsu Province。
Astragali Radix(AR) and Notoginseng Radix et Rhizoma(NR) are frequently employed in cardiovascular disease treatment. However, the efficacy of the AR-NR medicine pair(AN) in improving cardiac remodeling and its underl...
关键词:Astragali Radix-Notoginseng Radix et Rhizoma medicine pair Mitochondrial dynamics Transforming growth factor-β1/Smad3 pathway Cardiac hypertrophy Cardiac fibrosis 
Effects of steaming process on rare saponins and efficacy of Panax ginseng, Panax notoginseng and Panax quinquefolium被引量:1
《Chinese Herbal Medicines》2024年第4期521-528,共8页Wenjie Zhao Linlin Han Tao Li Jungjoon Lee Yuqing Zhao 
supported by the Higher Education Discipline Innovation Project (111 Project, D18012)。
The steamed Panax ginseng C. A. Mey., Panax notoginseng(Burk.) F. H. Chen, and Panax quinquefolium L. not only facilitate storage, but also increase the content of rare saponins and enhance their clinical application ...
关键词:Ginseng Radix et Rhizoma Notoginseng Radix et Rhizoma Panacis Quinquefolii Radix rare saponins steaming process 
Renshen(Radix Ginseng) polysaccharide promotes repair of the mice intestinal mucosa through regulatory mechanisms based on polyamine and human antigen R
《Journal of Traditional Chinese Medicine》2024年第6期1118-1126,共9页WANG Guanyu DAI Xingzhen LIU Yiting ZHU Zeming HU Ling LI Ruliu 
National Natural Science Foundation of China:Study on the Effect of Supplementing Qi and Invigorating the Spleen on the Migration of Small Intestinal Epithelial Cells through the Regulation of Polyamines and Calcium Ions (No. 81673940);First-class Discipline Construction Major Project of Guangzhou University of Chinese Medicine,Guangzhou University of Chinese Medicine Planning (2020) No. 62:based on the Viscous Characteristics of Dampness and Pathogenic Factors in Lingnan,this Paper Studied the Differential Characteristics of the Syndrome of Deficiency of Spleen and Stomach Disease and the Intervention Mechanism of Lingnan Traditional Chinese Medicine for Mucosal Damage Repair。
OBJECTIVE: To investigate the mechanism and effect of Renshen(Radix Ginseng) polysaccharide on the migration of intestinal epithelial cell line 6(IEC-6), as well as the repair mechanism of Renshen(Radix Ginseng) polys...
关键词:Renshen(Radix Ginseng) polysaccharides human antigen R post-transcriptional regulation cell movement intestinal mucosal damage repair 
Radix Sanguisorbae Improves Intestinal Barrier in Septic Rats via HIF-1α/HO-1/Fe^(2+)Axis
《Chinese Journal of Integrative Medicine》2024年第12期1101-1112,共12页LIU Yi-yan BAO Dai-qin ZHANG Zi-sen ZHU Yu LIU Liang-ming LI Tao 
Objective:To investigate whether Radix Sanguisorbae(RS,Diyu)could restore intestinal barrier function following sepsis using a cecal ligation and puncture(CLP)-induced septic rat model and lipopolysaccharide(LPS)-chal...
关键词:Radix Sanguisorbae SEPSIS ferroptosis intestinal barrier function network pharmacology Chinesemedicine 
川牛膝片产地趁鲜加工及其可行性
《湖北农业科学》2024年第11期114-121,共8页郭晓亮 穆森 段媛媛 胡昌强 黄浩 
湖北省支持企业技术创新发展项目(2021BAB131);国家现代农业产业技术体系建设专项(CARS-21);恩施州研究与开发项目(D20210039)。
为了优化川牛膝(Cyathulae Radix)片产地趁鲜切制加工工艺并验证其可行性,采用正交试验设计,考察初干温度、初干程度、发汗时间及复干温度对川牛膝片质量与干燥时长的影响,并通过质量评价与代谢组分析验证工艺的可行性。结果表明,4个因...
关键词:川牛膝(Cyathulae Radix)片 产地趁鲜加工 质量 代谢组 可行性 
Investigation of oligomeric proanthocyanidins extracted from Rhodiolae Crenulatae Radix et Rhizomes using deep eutectic solvents and identified via data-dependent acquisition mass-spectroscopy
《Journal of Pharmaceutical Analysis》2024年第11期1695-1706,共12页Li Jia Liming Wang Xiaoxiao Zhang Qingrui Zhang Peng Lei Yanxu Chang Lifeng Han Xin Chai Wenzhi Yang Yuefei Wang Miaomiao Jiang 
supported by the Science and Technology Program of Tianjin in China(Grant No.:23ZYJDSS00030);the Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine,China(Grant Nos.:22HHZYSS00007 and 22HHZYJC00003).
In this study,34 deep eutectic solvents(DESs)were successfully prepared for the extraction of proanthocyanidin from Rhodiolae Crenulatae Radix et Rhizomes.The extraction process was optimized using single factor explo...
关键词:PROANTHOCYANIDINS Deep eutectic solvent Rhodiolae Crenulatae Radix et Rhizomes Pharmacodynamic material basis 
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis
《Chinese Journal of Natural Medicines》2024年第9期769-784,共16页ZHANG Yinhao JIA Kexin LI Yufei MA Zhi FAN Guifang LUO Ranyi LI Yajing YANG Yang LI Fanghong LIU Runping LIU Jia LI Xiaojiaoyang 
supported by Beijing Nova Program(No.Z201100006820025);the National Natural Science Foundation of China(No.82274186);the Fundamental Research Funds for the Central Universities(No.2023-JYB-JBZD-046);the National High-Level Talents Special Support Program to LI Xiaojiaoyan;the National Key Research and Development Program on Modernization of Traditional Chinese Medicine(No.2022YFC3502100);Beijing Municipal Science&Technology Commission(No.7212174)。
Hepatic ischemia/reperfusion injury(HIRI)is a common pathophysiological condition occurring during or after liver resection and transplantation,leading to hepatic viability impairment and functional deterioration.Rece...
关键词:Hepatic ischemia/reperfusion injury Rehmanniae Radix Praeparata Ferroptosis Intracellular iron homeostasis 
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