The role played by serendipity in the origin of modern psychopharmacology has proven to be controversial in scientific literature.In its original meaning(Walpole),serendipity refers to discoveries made through a combi...
Frontal lobe epilepsy has a complex and atypical semiology that may masquerade as psychiatric or parasomnias[1].An electroencephalography(EEG)and sleep lab workup should be an integral part of clinical assessment of t...
the National Natural Science Foundation of China(Nos.81570413,81773732,and 81973509).
Leptin resistance in endothelial cells leads to vascular endothelial dysfunction,which is the beginning and crucial link of atherosclerosis.However,the mechanism of leptin resistance remains obscure.Acid sphingomyelin...
Our current study aims to explore the interaction of melatonin (MEL) with the monoaminergic system on the pathophysiology of affective disorders in Wistar rats. We mention here that, the role of monoaminergic transmis...
the the Fundacao para a Ciência e Tecnologia(FCT)and Internationale Stichting Alzheimer Onderzoek(ISAO);the Netherlands,grant N 09501 and RFBR 11-04-01411 to TS
Objective: We sought to investigate the efficacy of oral dosing in mice with imipramine(7mg/kg/day) via water or in food pellets, and to compare its effects in the paradigms of learned helplessness, locomotion, hedoni...
Aim: Major depressive disorder (MDD) is a debilitating mental disorder associated with dysfunction of the neurotransmitter- neuroendocrine system and neuroinflammatory responses. Salvianolic acid B (SalB) has sho...
Nocturnal enuresis often causes considerable distress or functional impairment to patient and their parents necessitating a multidisciplinary approach from paediatrician, paediatric nephrologist, urologists and psychi...
Retinal ganglion cell(RGC) degeneration is irreversible in glaucoma and tyrosine kinase receptor B(Trk B)-associated signaling pathways have been implicated in the process.In this study,we attempted to examine whe...
Supported by Fondazione Banco di Sardegna,Italy(Grant no 2013 U718/AI.642.MGB)
AIM: To evaluate antidepressant-like effect of memantine in a rat model.METHODS: Male Wistar rats were treated intraperitoneally with either vehicle, memantine(10 mg/kg) or imipramine(20 mg/kg), for 3 wk. Twenty-four ...
Introduction:?Enuresis is one of the most common psychiatric disorders in children. Classical?treatments for primary enuretic children are conditioning (Bell and Pad method, and drug therapy). Neurofeedback is a kind ...