funded by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant No.G:455-248-1442。
Objective:To assess the effect of memantine combined with liraglutide on aluminum chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in rats.Methods:Male Wistar rats were divided into 5 groups of 5 animals...
supported by the 2019-2020 TCM Technology Development Project of Shandong Province(No.2019-0044);Guangdong Basic and Applied Basic Research Foundation(No.2019A1515010644);Project of Traditional Chinese Medicine Bureau of Guangdong Province(No.20201073);General Program of National Natural Science Foundation of China(No.82074306)。
Objective:To evaluate the efficacy and safety of Chinese herbal medicines(CHMs)combined with chemical drugs for the treatment of Alzheimer's disease(AD).Materials and Methods:Databases were searched to retrieve random...
Objective: to explore whether citicoline combined with memantine therapy can help patients return to normal life as soon as possible for the majority of patients with vascular dementia. Methods: selected 150 patients ...
OBJECTIVE Alzheimer disease(AD)is a leading cause of dementia in elderly individuals and therapeutic options for AD are very limited.Over-activation of N-methyl-D-aspar⁃tate(NMDA)receptors,amyloidβ(Aβ)aggrega⁃tion,a...
Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the brain.In this disease,two different damage areas are identifying:the lesion core,in which cells ...
Alzheimer disease is one of the commonest neurological diseases which is characterized by amyloid plaques accumulation in multiple brain regions. This study investigated the potential neuroprotective effect of artesun...
the support by Neuroscience Research Center,Kaohsiung Medical University,KMU-TC108B01.
Current treatment paradigm in Alzheimer’s disease(AD)involves multiple approaches combining pharmacological and nonpharmacological intervention to mitigate the clinical symptoms,slow the progressive loss of cognitive...
BACKGROUND: The role of the amygdala in controlling emotional pain has been emphasized in several studies. In this study, the role of the NMDA glutamate receptors in the basolateral nucleus of the amygdala (BLA) in...
One strategy to reduce neurocognitive deterioration in patients after brain irradiation is the use of neuroprotective medication.To generate up-to date knowledge regarding neuroprotective agents we performed a systema...
Supported by the National Natural Science Foundation of China(No.81172982), the Natural Science Foundation of Guang- dong Province of China(No.2015A030311012) and the Fundamental Research Funds for the Central Universities of China(No. 11615323).
Ten memantine(Mema)-dihydroartemisinin(DHA) ligands were designed and synthesized. Three types of isomers including α, β, and a defined y isomer were found in each intermediates(1a--1e). Type γ isomer was fir...