Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease  

作　　者：Duaa M.Bakhshwin Foziya W.Alhalabi Mohamad Omar Barasheed Ahmed M.Bakhshwin Maha H.Jamal Mohammed A.Bazuhair Fatemah O.Kamel Rania M.Magadmi Zoheir A Damanhouri Samar M.Alsaggaf 

机构地区：[1]Department of Clinical Pharmacology,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia [2]Hera General Hospital,Makkah,Saudi Arabia [3]Department of Pathology,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia [4]Department of Clinical Anatomy,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第5期207-214,共8页亚太热带生物医学杂志（英文版）

基　　金：funded by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant No.G:455-248-1442。

摘　　要：Objective:To assess the effect of memantine combined with liraglutide on aluminum chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in rats.Methods:Male Wistar rats were divided into 5 groups of 5 animals each:the positive control,the negative control,the memantine-treated group,the liraglutide-treated group,and the combination group treated with memantine and liraglutide.AlCl_(3)and D-GAL were used to induce neurotoxicity.Behavioral tests,brain beta-amyloid protein,and oxidative stress biomarkers were evaluated.Results:The Morris water maze test indicated an enhanced memory in the combination group.Moreover,the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain tissue.Neuronal inflammation and oxidative stress biomarkers were significantly reduced,and the levels of antioxidant parameters were enhanced.Conclusions:The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer’s disease.

关 键 词：Alzheimer’s disease Cognitive function Glucagonlike peptide-1 LIRAGLUTIDE MEMANTINE 

分 类 号：R285.5[医药卫生—中药学]