RIVASTIGMINE

作品数：20被引量：35H指数：3
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相关领域：医药卫生更多>>
相关作者：王晓良更多>>
相关机构：北京协和医学院中国医学科学院北京协和医学院更多>>
相关期刊：《中华医学信息导报》《国外药讯》《Chinese Medicine》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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Divergent Protein Engineering of Transaminase for the Synthesis of Chiral Rivastigmine and Apremilast Precursors
《Chinese Journal of Chemistry》2024年第19期2335-2340,共6页Langyu Tang Xinjie Yang Ningning Sun Guojiao Wu Yuzhou Wu Fangrui Zhong 
the National Key R&D Program of China(No.2021YFF1200203 to G.W.and 2018YFA0903500 to F.Z.);Hubei Provincial Key R&D program(2021BAA168 to Y.W.);Shen-Zhen Science and Technology Program(JCYJ20220530160805011 to F.Z.);the interdisciplinary research program of Huazhong University of Science and Technology(HUST)(2023JCYJ001 to F.Z.);the China Postdoctoral Science Foundation(2023M741259 to X.Y.)for financial supports.
Comprehensive Summary The implementation of divergent protein engineering on the natural transaminase Vf-ω-TA led to the development of two effective mutants(M2 and M8),enabling the enzymatic synthesis of chiral amin...
关键词：Asymmetric catalysis Chiral amine Protein engineering Directed evolution BIOCATALYSIS TRANSAMINASE ENANTIOSELECTIVITY Syntheticmethods AMINATION Enzymes 
Efficacy and Safety of Chinese Herbal Medicines Combined with Chemical Drugs for Alzheimer's Disease:A Systematic Review and Meta-Analysis
《World Journal of Traditional Chinese Medicine》2024年第1期1-13,共13页Li Xu Wen-Jun Chen Cai-Jun Tian Yan Zhang Yan Ma Tian-Hao Li Hong-Jie Liu Zhe Zhang 
supported by the 2019-2020 TCM Technology Development Project of Shandong Province(No.2019-0044);Guangdong Basic and Applied Basic Research Foundation(No.2019A1515010644);Project of Traditional Chinese Medicine Bureau of Guangdong Province(No.20201073);General Program of National Natural Science Foundation of China(No.82074306)。
Objective:To evaluate the efficacy and safety of Chinese herbal medicines(CHMs)combined with chemical drugs for the treatment of Alzheimer's disease(AD).Materials and Methods:Databases were searched to retrieve random...
关键词：Alzheimer's disease Chinese herbal medicine DONEPEZIL MEMANTINE META-ANALYSIS randomized controlled trials RIVASTIGMINE 
Framework of treating Alzheimer’s dementia
《Brain Science Advances》2019年第2期82-93,共12页Yuan-Han Yang Rajka Liscic Jacqueline Dominguez 
the support by Neuroscience Research Center,Kaohsiung Medical University,KMU-TC108B01.
Current treatment paradigm in Alzheimer’s disease(AD)involves multiple approaches combining pharmacological and nonpharmacological intervention to mitigate the clinical symptoms,slow the progressive loss of cognitive...
关键词：DONEPEZIL RIVASTIGMINE GALANTAMINE MEMANTINE Alzheimer’s disease 
Comparative efficacy and safety of cognitive enhancers for treating vascular cognitive impairment: systematic review and Bayesian network meta-analysis被引量：10
《Neural Regeneration Research》2019年第5期805-816,共12页Bo-Ru Jin Hua-Yan Liu 
supported by the Natural Science Foundation of Liaoning Province of China,No.20170541036(to HYL)
Objective: To assess and compare the clinical efficacy and safety of cognitive enhancers(donepezil, galantamine, rivastigmine, and memantine) on cognition, behavior, function, and global status in patients with vascul...
关键词：nerve REGENERATION VASCULAR cognitive impairment VASCULAR dementia pharmacotherapy cholinesterase inhibitors DONEPEZIL GALANTAMINE RIVASTIGMINE memantine systematic review Bayesian network META-ANALYSIS neural REGENERATION 
Design, synthesis and evaluation of genistein-polyamine conjugates as multi-functional anti-Alzheimer agents被引量：2
《Acta Pharmaceutica Sinica B》2015年第1期67-73,共7页Xin Zhang Jiang Wang Chen Hong Wen Luo Chaojie Wang 
the National Natural Science Foundation of China (Nos. 21172053 and 21302041);the China Postdoctoral Science Foundation (No. 2012M521391);the Postdoctoral Science Foundation of Henan Province (No. 2011015);the Foundation of Henan Educational Committee (No. 14A350008)
A series of genistein-polyamine conjugates(4a–4h) were designed, synthesized and evaluated as multi-functional anti-Alzheimer agents. The results showed that these compounds had significant cholinesterases(Ch Es) inh...
关键词：GENISTEIN POLYAMINE Alzheimer’s disease ACETYLCHOLINESTERASE Molecular modeling Metal-chelating Inhibition RIVASTIGMINE 
Rivastigmine Restores 5-HT<sub>1A</sub>Receptor Levels in the Hippocampus of Olfactory Bulbectomized Mice
《Advances in Alzheimer's Disease》2014年第3期128-136,共9页Muhammad Rashedul Islam Shigeki Moriguchi Hideaki Tagashira Kohji Fukunaga 
Rivastigmine, a dual acetylcholinesterase and butyrylcholinesterase inhibitor, is used for symptomatic treatment of patients with mild to moderately severe dementia in Alzheimer’s disease (AD) patients. In the presen...
关键词：RIVASTIGMINE 5-HT1A RECEPTOR 5-HT2A RECEPTOR NICOTINIC Acetylcholine RECEPTOR Olfactory Bulbectomized MICE 
Randomized, Placebo-Controlled Trial of Transdermal Rivastigmine for the Treatment of Encephalopathy in Liver Cirrhosis (TREC Trial)
《Open Journal of Gastroenterology》2014年第6期255-264,共10页Patrick P. Basu Niraj James Shah Mark M. Aloysius Robert S. Brown 
Objectives: Cognitive dysfunction in patients with hepatic encephalopathy (HE) may be caused by alterations in cholinergic neurotransmission. The objective of the study was to evaluate the efficacy and safety of trans...
关键词：ACETYLCHOLINESTERASE CHOLINERGIC Function Hepatic ENCEPHALOPATHY RIVASTIGMINE 
Effects of Rivastigmine Combined with Reinhartdt and Sea Cucumber Capsule in Patients with Mild-to-Moderate Parkinson’s Disease Dementia: A Pilot Study被引量：1
《Chinese Medicine》2014年第2期94-103,共10页Yongxing Yan Lizhen Liang Tao Xie Yonghui Shen Yanjing Cao 
Many patients with Parkinson’s disease suffer cognitive impairment or dementia. Cholinesterase inhibitors (ChEIs) have positive effects on patients with Parkinson’s Disease Dementia (PDD). But it is only improve sym...
关键词：Parkinson’s Disease Cognitive Function RIVASTIGMINE Reinhartdt and Sea CUCUMBER 
Acetylcholinesterase inhibitors in cognitive impairment in Huntington's disease: A brief review
《World Journal of Psychiatry》2013年第3期62-64,共3页Joe John Vattakatuchery Renjith Kurien 
Huntington's disease(HD) is a neurodegenerative disease associated with cognitive deficits. Cognitive dysfunction may be present in the early stages of the disease, even before the onset of motor symptoms. The cogniti...
关键词：Huntington’s disease Huntington’s DEMENTIA Cognitive deficits ACETYLCHOLINESTERASE INHIBITORS DONEPEZIL RIVASTIGMINE GALANTAMINE 
Third degree atrioventricular block associated with treatment with rivastigmine transdermal patch被引量：2
《Journal of Geriatric Cardiology》2013年第1期113-115,共3页Fredrikke C. Knudtzen Thomas B. Christophersen 
Rivastigmine transdermal patch is indicated for patientswithAlzheimer’s disease and dementia with Parkinson’s disease. Rivastigmine, an acetylcholinesterase inhibitor, has several common adverse effects, mainly invo...
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