NICOTINIC

作品数：51被引量：96H指数：4
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相关领域：医药卫生更多>>
相关作者：刘传缋郑建全杨爱珍何湘平韩召军更多>>
相关机构：军事医学科学院贵阳医学院南京农业大学更多>>
相关期刊：《Chinese Medical Journal》《Neuroimmunology and Neuroinflammation》《World Journal of Diabetes》《World Journal of Neuroscience》更多>>
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Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models
《Translational Neurodegeneration》2024年第1期200-214,共15页Saige K.Power Sridevi Venkatesan Sarah Qu JoAnne McLaurin Evelyn K.Lambe 
funded by research grants from the Canadian Institutes of Health(CIHR):MOP 89825,EKL;PRJ153101,EKL and JM;support of a CIHR Banting and Best Canada Graduate Scholarship and an Ontario Graduate Scholarship,SKP.
Background Cognitive reserve allows for resilience to neuropathology,potentially through active compensation.Here,we examine ex vivo electrophysiological evidence for active compensation in Alzheimer’s disease(AD)foc...
关键词：Alzheimer’s disease Cognitive reserve Prefrontal cortex ACETYLCHOLINE Nicotinic receptors OPTOGENETICS ELECTROPHYSIOLOGY Acetylcholinesterase inhibitor Compensation 
A selective literature review exploring the role of the nicotinic system in schizophrenia
《General Psychiatry》2023年第2期86-91,共6页Guna Kanniah Rishi Kumar 
Nicotine use is more prevalent in patients with psychiatric disorders,especially those diagnosed with psychotic illnesses.Previously,this higher prevalence has been partially attributed to the potential ameliorative e...
关键词：SYSTEM attributed potential 
Nicotinic acetylcholine signaling is required for motor learning but not for rehabilitation from spinal cord injury
《Neural Regeneration Research》2023年第2期364-367,共4页Yue Li Edmund R.Hollis II 
supported by the Burke Foundation and the National Institutes of Health Common Fund,No.DP2 NS106663(to ERH);the New York State Department of Health Spinal Cord Injury Research Board Postdoctoral Fellowship,No.C32633GG(to YL)。
Therapeutic intervention for spinal cord injury is limited,with many approaches relying on strengthening the remaining substrate and driving recovery through rehabilitative training.As compared with learning novel com...
关键词：ACETYLCHOLINE basal forebrain corticospinal tract dorsal column lesion mecamylamine METHYLLYCACONITINE motor control REHABILITATION ROTAROD single pellet-reaching task 
The actions of neonicotinoid insecticides on nicotinic acetylcholine subunits Ldα1 and Ldα8 of Leptinotarsa decemlineata and assembled receptors被引量：1
《Insect Science》2022年第5期1387-1400,共14页Zhi-Min Wang Sha Li Cheng-Cheng Shi Lin-Jie Xie Kai-Yun Fu Wei-Hua Jiang 
funded by National Key Re-search and Development Project of China(No.2018YFD0200802).
The insect nicotinic acetylcholine receptor(nAChR)is a pentameric channel protein and also a target for neonicotinoids.There are few reported studies on the molecular interactions of Leptinotarsa decemlineata nAChRs w...
关键词：expression IMIDACLOPRID Leptinotarsa decemlineata nicotinic acetylcholine receptor THIAMETHOXAM Xenopus oocyte 
Knockin of the G275E mutation of the nicotinic acetylcholine receptor (nAChR) α6 confers high levels of resistance to spinosyns in Spodoptera exigua被引量：1
《Insect Science》2022年第2期478-486,共9页Ya-Yun Zuo Yu-Xin Xue Ze-Yu Wang Xuan Ren Ahmed A.A.Aioub Yi-Dong Wu Yi-Hua Yang Zhao-Nong Hu 
funded by the National Natural Science Foundation of China(32001941 and 31972303);the China Postdoctoral Science Foundation(2020M683586);the Research Fund for the Doctoral Program of Northwest A&F University(Z1090219195).
Spinosyns,including spinosad and spinetoram,act on the insect central nervous system,gradually paralyzing or destroying the target insect.Spinosad resistance is associated with loss-of-function mutations in the nicoti...
关键词：beet armyworm CRISPR G275E mutation nicotinic acetylcholine recep・tor spinosyns insecticides target resistance 
Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease被引量：3
《Neural Regeneration Research》2021年第6期1099-1104,共6页Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon 
supported by Inserm(to SV,LFF,CT,JV,SB,SS,SC);by the Labex IRON(ANR-11-LABX-18-01:to all authors).
To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease.It was recently observed in a rodent model of Alzheimer’s disease that the interaction ...
关键词：6-HYDROXYDOPAMINE astrocytes microglial activation neurodegeneration neuroinflammation nicotinicα7 receptor Parkinson’s disease PHA 543613 PRE-084 sigma-1 receptor 
Targeting the cholinergic system in Parkinson’s disease被引量：4
《Acta Pharmacologica Sinica》2020年第4期453-463,共11页Changliang Liu 
supported by the Gordon Fellowship from Harvard Medical School(to Changliang Liu).
Motor control in the striatum is an orchestra played by various neuronal populations.Loss of harmony due to dopamine de?ciency is considered the primary pathological cause of the symptoms of Parkinson’s disease(PD).R...
关键词：Parkinson’s disease motor control ACETYLCHOLINE DOPAMINE NICOTINIC receptor 
Differentiation of the Agonists and Antagonists of the α7 Nicotinic Acetylcholine Receptor
《Journal of Ocean University of China》2019年第5期1193-1198,共6页WU Guanzhao XU Qingliang BAO Yilei LIU Yuwei LI Qian FANG Zhengyu FU Jingyi DING Yuhang LIANG Zhiqing JIANG Tao YU Rilei 
supported by the Fundamental Research Funds for the Central Universities (No. 201762011 for R. Y.);National Laboratory Director Fund from the Qingdao National Laboratory of Marine Science and Technology (No. QNLM201709);the NSFC-Shandong Joint Fund (No. U1406402)
Theα7 nicotinic acetylcholine receptors(nAChRs)are widely expressed in the central and peripheral nervous systems and are important drug targets for the treatment of neurological diseases.However,differentiation of t...
关键词：NICOTINIC ACETYLCHOLINE RECEPTORS LIGAND efficacy LIGAND BINDING AFFINITY LIGAND efficiency 
S5A-3 Increased Blood Pressure Variability Impairs Memory in Rats
《神经药理学报》2018年第4期79-79,共1页ZHU Chao DU Ning-ning ZHOU Yan-meng WANG Hao HOU Xue-qin ZHANG Fang-fang TAN Rui GAO Shan JIA Xiao-li WANG Wei 赵晓民 ZHANG Han-ting 
This work was supported by the Natural Science Foundation of Shandong Province of China(ZR2014HQ007,ZR2017MH048),the Foundation of Overseas Distinguished Taishan Scholars of Shandong Province of China(to H-TZ)and Collaborative Innovation Center for Research and Development of Traditional Chinese Medicine in Mount Tai.
Background and Objective:Increased blood pressure variability(BPV),which has been considered to cause brain damage,can be induced by sinoaortic denervation(SAD)in rats.This study was designed to test the hypothesis th...
关键词：blood pressure variability sinoaortic DENERVATION MEMORY CHOLINERGIC α7 NICOTINIC ACETYLCHOLINE receptor 
Cholinergic receptor, nicotinic, alpha 7 as a target molecule of Arctic mutant amyloid β
《Neural Regeneration Research》2018年第8期1360-1361,共2页Naoya Sawamura Ye Ju Toru Asahi 
supported by a grant KAKENHI 15K06786;the Center of Innovation Science and Technology based Radical Innovation and Entrepreneurship Program(COI STREAM)of the Ministry of Education,Culture,Sports,Science and Technology(MEXT),Japan
Alzheimer’s disease（AD）is a progressive cognitive disorder that develops predominantly in elderly patients and is characterized by cognitive impairments affecting memory,learning,and attention（Selkoe,2002）.
关键词：Cholinergic receptor alpha 7 as a target molecule of Arctic mutant amyloid NICOTINIC AD 
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