S5A-3 Increased Blood Pressure Variability Impairs Memory in Rats  

作　　者：ZHU Chao DU Ning-ning ZHOU Yan-meng WANG Hao HOU Xue-qin ZHANG Fang-fang TAN Rui GAO Shan JIA Xiao-li WANG Wei 赵晓民 ZHANG Han-ting ZHAO Xiao-min

机构地区：[1]Institute of Pharmacology,Taishan Medical University,Taian,271016,China

出　　处：《神经药理学报》2018年第4期79-79,共1页Acta Neuropharmacologica

基　　金：This work was supported by the Natural Science Foundation of Shandong Province of China(ZR2014HQ007,ZR2017MH048),the Foundation of Overseas Distinguished Taishan Scholars of Shandong Province of China(to H-TZ)and Collaborative Innovation Center for Research and Development of Traditional Chinese Medicine in Mount Tai.

摘　　要：Background and Objective:Increased blood pressure variability(BPV),which has been considered to cause brain damage,can be induced by sinoaortic denervation(SAD)in rats.This study was designed to test the hypothesis that increased BPV impairs learning and memory in rats with SAD.Methods:SAD was performed in male Sprague-Dawley rats.Passive avoidance trial was used to evaluate learning and memory ability.Results:Compared with shamoperated(Sham)group,there was no significant difference in the latency of passive avoidance in adaption trial.The latency of avoiding darkness in retention trial in SAD group was significantly lower than that in Sham group both 2 and 16 weeks after SAD(P<0.05,P<0.01).Westernblot assay revealed that all the expression of choline acetyltransferase,vesicular acetylcholine transporter andα7 nicotinic acetylcholine receptor decreaed in both cerebral cortex(P<0.05)and hippocampus(P<0.05)16 weeks after SAD(P<0.05),while only level ofα7 nicotinic acetylcholine receptor was reduced in hippocampus 2 weeks after SAD(P<0.05).Conclusion:Increasd BPV reduces memory ability in SAD rats,potentially through cholinergic pathway.

关 键 词：blood pressure variability sinoaortic DENERVATION MEMORY CHOLINERGIC α7 NICOTINIC ACETYLCHOLINE receptor 

分 类 号：R74[医药卫生—神经病学与精神病学]