METHYLLYCACONITINE

作品数：4被引量：9H指数：1
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相关领域：医药卫生更多>>
相关机构：滨州医学院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Neural Regeneration Research》《Chinese Chemical Letters》《BIOCELL》更多>>
相关基金：国家自然科学基金更多>>
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α7nAChR inhibition by methyllycaconitine citrate promotes cell pyroptosis by triggering the polyol pathway in cervical cancer cells
《BIOCELL》2024年第2期283-291,共9页JUNYING XU PING LI GE WANG DAQIANG YE XIUFU TANG 
supported by the Zhuhai Science and Technology Plan(ZH22036201210174PWC).
Background:α7 nicotinic acetylcholine receptor(α7nAChR)has been demonstrated to be involved in numerous of inflammatory diseases.Cell pyroptosis is a kind of cell death accompanied by inflammation.Objectives:The obj...
关键词：α7nAChR Cell pyroptosis AKR1B1 NF-κB 
Nicotinic acetylcholine signaling is required for motor learning but not for rehabilitation from spinal cord injury
《Neural Regeneration Research》2023年第2期364-367,共4页Yue Li Edmund R.Hollis II 
supported by the Burke Foundation and the National Institutes of Health Common Fund,No.DP2 NS106663(to ERH);the New York State Department of Health Spinal Cord Injury Research Board Postdoctoral Fellowship,No.C32633GG(to YL)。
Therapeutic intervention for spinal cord injury is limited,with many approaches relying on strengthening the remaining substrate and driving recovery through rehabilitative training.As compared with learning novel com...
关键词：ACETYLCHOLINE basal forebrain corticospinal tract dorsal column lesion mecamylamine METHYLLYCACONITINE motor control REHABILITATION ROTAROD single pellet-reaching task 
Synthesis of [6-6-6] ABE tricyclic ring analogues of methyllycaconitine
《Chinese Chemical Letters》2021年第10期3031-3033,共3页Dan Xiao Xin Zhao Jiang Lei Mengqian Zhu Liang Xu 
National Natural Science Foundation of China (Nos.21472129 and 21871190) for financial support of this work by grants。
A new synthesis of the bridged [6-6-6] ABE tricyclic ring analogues of methyllycaconitine with the C-1 oxygenated substituents has been developed using an efficient aza-annulation of β-enamino ketone followed by a fa...
关键词：C19-Diterpenoid alkaloids METHYLLYCACONITINE AZA-ANNULATION DECARBOXYLATION Acyl radical cyclization 
3rain protection against ischemic stroke using choline as a new molecular bypass treatment被引量：9
《Acta Pharmacologica Sinica》2015年第12期1416-1425,共10页Xin JIN Ru-huan WANG Hui WANG Chao-liang LONG Hai WANG 
Aim： To determine whether administration of choline could attenuate brain injury in a rat model of ischemic stroke and the underlying mechanisms. Methods： A rat model of ischemic stroke was established through perma...
关键词：ischemic stroke pMCAO rats CHOLINE METHYLLYCACONITINE NEOVASCULARIZATION α7 nicotinic acetylcholine receptor HIF-1Α VEGF ANGIOGENESIS brain microvascular endothelial cells 
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