Synthesis of [6-6-6] ABE tricyclic ring analogues of methyllycaconitine  

作　　者：Dan Xiao Xin Zhao Jiang Lei Mengqian Zhu Liang Xu 

机构地区：[1]Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education,West China School of Pharmacy,Sichuan University,Chengdu 610041,China [2]State Key Laboratory of Biotherapy,West China Hospital,West China Medical School,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2021年第10期3031-3033,共3页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China (Nos.21472129 and 21871190) for financial support of this work by grants。

摘　　要：A new synthesis of the bridged [6-6-6] ABE tricyclic ring analogues of methyllycaconitine with the C-1 oxygenated substituents has been developed using an efficient aza-annulation of β-enamino ketone followed by a facile decarboxylation to form BE rings.Subsequent elaboration to form the A ring was achieved by a transannular acyl radical cyclization with concomitant equipment of the key C-1 oxygen functionality.

关 键 词：C19-Diterpenoid alkaloids METHYLLYCACONITINE AZA-ANNULATION DECARBOXYLATION Acyl radical cyclization 

分 类 号：TQ464.2[化学工程—制药化工]