CHOLINE

作品数：133被引量：439H指数：11
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相关领域：医药卫生更多>>
相关作者：李永红黄宗文张鸿彦陈翼洪愉更多>>
相关机构：复旦大学成都军区昆明总医院四川大学华西医院山东大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金江苏省自然科学基金更多>>
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Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
《Acta Pharmacologica Sinica》2024年第9期1912-1925,共14页Mo-ting Liu Yao Zhang Cai-gui Xiang Tao Yang Xiao-han Wang Qiu-kai Lu Hui-min Lu Chen Fan Chun-lan Feng Xiao-qian Yang Duo-wu Zou Heng Li Wei Tang 
National Natural Science Foundation of China(No.82173822).
Ulcerative colitis(UC)is associated with changed dietary habits and mainly linked with the gut microbiota dysbiosis,necroptosis of epithelial cells,and mucosal ulcerations.Liver dysfunction and abnormal level of liver...
关键词：ulcerative colitis dyslipidemia methionine-choline deficient diet MACROPHAGES gut microbes fecal microbiota transplantation 
Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation
《Hepatobiliary Surgery and Nutrition》2024年第3期393-411,I0001,I0002,共21页Chen Wang Zhao-Yan Liu Wen-Ge Huang Zhi-Jun Yang Qiu-Ye Lan Ai-Ping Fang Meng-Jun Hou Xiao-Lin Luo Yao-Jun Zhang Si Chen Hui-Lian Zhu 
Basic and Applied Basic Research Foundation of Guangdong Province,China(grant No.2020A1515110682);Guangdong Provincial Science and Technology Project(grant No.2017A040406008);National Natural Science Foundation of China(grant Nos.81973016,82103825);Postdoctoral Science Foundation of China(grant No.2020M683135).
Background:Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-associated death.Emerging evidence suggests that autophagy plays a critical role in HCC tumorigenesis,metastasis,and prognosis.Choline is ...
关键词：Hepatocellular carcinoma(HCC) AUTOPHAGY CHOLINE solute carrier family 5 member 7(SLC5A7) 
Bao-Gan-Xiao-Zhi-Wan Treatment Attenuates Methionine-choline-deficient Diet-induced Metabolic Dysfunction-associated Steatohepatitis in Rats by Modulating the NF-κB Signal Pathway and Autophagy
《Journal of Clinical and Translational Hepatology》2024年第6期607-611,共5页Liming Zhou Xiaobin Zeng Xiaofang Wei Wanying Shen Jie Yao Weigang Wu Lanlan Ge Boping Zhou 
supported by the Basic and Applied Basic Research Foundation of Guangdong Province(2021A1515220185).
Non-alcoholic fatty liver disease(NAFLD)is a condition involving the accumulation of liver fat in excess of 5–10%of its weight after excluding excessive alcohol intake and any other causes of liver disease or steatos...
关键词：NAFLD liver INTAKE 
A Pt/CeO_(2)Hybrid Nanozyme with Stable Peroxidase Activity for the Detection of Acetylcholine
《Chemical Research in Chinese Universities》2024年第2期268-271,共4页CUI Xulian MA Baofu PAN Hui XIA Yu LIU Li ZHAO Baofeng LIANG Zhen ZHANG Lihua ZHANG Yukui 
supported by the National Natural Science Foundation of China(No.32371505);the Innovation Fund Project of the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences(Nos.DMU-1&DICP UN202204,DICPI202110).
Acetylcholine(ACh)is a common neurotransmitterl)that is secreted by cholinergic neurons[2]and is found mainly in the peripheral and central nervous systems.[3]ACh transmits nerve signals from presynaptic to postsynapt...
关键词：Acetylcholine/choline Nanozyme Hydrogen peroxide Alzheimer’s disease 
MFSD7c functions as a transporter of choline at the blood–brain barrier
《Cell Research》2024年第3期245-257,共13页Xuan Thi Anh Nguyen Thanh Nha Uyen Le Toan Q.Nguyen Hoa Thi Thuy Ha Anna Artati Nancy C.P.Leong Dat T.Nguyen Pei Yen Lim Adelia Vicanatalita Susanto Qianhui Huang Ling Fam Lo Ngah Leong Isabelle Bonne Angela Lee Jorge L.Granadillo Catherine Gooch Dejie Yu Hua Huang Tuck Wah Soong Matthew Wook Chang Markus R.Wenk Jerzy Adamski Amaury Cazenave-Gassiot Long N.Nguyen 
supported in part by Singapore Ministry of Health's National Research Council NMRC/OFIRG/0066/20,Singapore Ministry of Education grants (T2EP30221-0012,T2EP30123-0014,and NUHSRO/2022/067/T1 (to L.N.N.));the Synthetic Biology Translational Research Programme of the Yong Loo Lin School of Medicine of the National University of Singapore (NUHSRO/2020/077/MSC/02/SB to M.W.C.).
Mutations in the orphan transporter MFSD7c(also known as Flvcr2),are linked to Fowler syndrome.Here,we used Mfsd7c knockout(Mfsd7c^(-/-))mice and cell-based assays to reveal that MFSD7c is a choline transporter at the...
关键词：MFS BARRIER sized 
Dietary choline activates the Ampk/Srebp signaling pathway and decreases lipid levels in Pacific white shrimp(Litopenaeus vannamei)被引量：1
《Animal Nutrition》2023年第4期58-70,共13页Jingjing Lu Xinyue Tao Jiaxiang Luo Tingting Zhu Lefei Jiao Peng Sun Qicun Zhou Douglas R.Tocher Min Jin 
supported by the Natural Science Foundation of Zhejiang Province(LY21C190006,LY17C190002);the National Key R&D Program of China(2018YFD0900400);China Agriculture Research System-48(Supported by China Agriculture Research System of MOF and MARA);National Natural Science Foundation of China(32072987);the K.C.Wong Magna Fund of Ningbo University,China.
An 8-week feeding trial was conducted in Pacific white shrimp(Litopenaeus vannamei)to evaluate the effects of dietary choline supplementation on choline transport and metabolism,hepatopancreas histological structure a...
关键词：Pacific white shrimp CHOLINE Lipid Fatty acid Histology Ampk signaling pathway 
Maternal dietary deficiencies in folic acid or choline worsen stroke outcomes in adult male and female mouse offspring
《Neural Regeneration Research》2023年第11期2443-2448,共6页McCoy Clementson Lauren Hurley Sarah Coonrod Calli Bennett Purvaja Marella Agnes S.Pascual Kasey Pull Brandi Wasek Teodoro Bottiglieri Olga Malysheva Marie A.Caudill Nafisa M.Jadavji 
American Heart Association,No.20AIREA35050015 (to NMJ)。
Maternal one-carbon metabolism plays an important role in early life programming.There is a well-established connection between the fetal environment and the health status of the offspring.Howeve r,there is a knowledg...
关键词：APOPTOSIS choline metabolism folic acid ischemic stroke maternal diet motor function one-carbon metabolism stroke outcome 
Volumetric and ultrasonic properties of thiamine hydrochloride drug in aqueous solutions of choline-based deep eutectic solvents at different temperatures
《Chinese Journal of Chemical Engineering》2023年第10期21-30,共10页Hemayat Shekaari Fariba Ghaffari Masumeh Mokhtarpour 
financial support from the graduate council of the University of Tabriz,Tabriz,Iran.
Important efforts have been made over the past years to improve the drug acts,which leads to the discovery of novel drug preparations and delivery systems.The optimal design of such processes requires a molecular-leve...
关键词：Deep eutectic solvents Thiamine hydrochloride Density Speed of sound Redlich-Meyer equation 
Alternative splicing of a carboxyl/choline esterase gene enhances the fenpropathrin tolerance of Tetranychus cinnabarinus
《Insect Science》2023年第5期1255-1266,共12页Peng Wei Xinying Zeng Haonan Han Yiqing Yang Youjun Zhang Lin He 
supported in part by the National Nature Sciences Foundation(32001935 and 31972297);the Fundamental Research Funds for the Central Universities(SWU-KR22005).
Detoxification plays a crucial role in agricultural pests to withstand pesticides,and cytochrome P450s,carboxyl/choline esterases(CCEs),and glutathione-S-transferases are the main proteins responsible for their detoxi...
关键词：alternative splicing carboxyl/choline esterase(CCE) detoxification function PYRETHROID pests 
Choline dehydrogenase interacts with SQSTM1 to activate mitophagy and promote coelomocyte survival in Apostichopus japonicus following Vibrio splendidus infection
《Zoological Research》2023年第5期905-918,共14页Lian-Lian Sun Ying-Fen Dai Mei-Xiang You Cheng-Hua Li 
supported by the National Natural Science Foundation of China (32102825);Natural Science Foundation of Zhejiang Province (LQ22C190003)。
Previous studies have shown that Vibrio splendidus infection causes mitochondrial damage in Apostichopus japonicus coelomocytes,leading to the production of excessive reactive oxygen species(ROS)and irreversible apopt...
关键词：Choline dehydrogenase MITOPHAGY SQSTM1 Microtubule-associated protein 1 light chain 3 Apostichopus japonicus 
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