Nicotinic acetylcholine signaling is required for motor learning but not for rehabilitation from spinal cord injury  

作　　者：Yue Li Edmund R.Hollis II 

机构地区：[1]Burke Neurological Institute,White Plains,NY,USA [2]Feil Family Brain and Mind Research Institute,Weill Cornell Medicine,New York,NY,USA [3]Current address:Department of Neuroscience,University of Rochester Medical Center,Rochester,NY,USA

出　　处：《Neural Regeneration Research》2023年第2期364-367,共4页中国神经再生研究（英文版）

基　　金：supported by the Burke Foundation and the National Institutes of Health Common Fund,No.DP2 NS106663(to ERH);the New York State Department of Health Spinal Cord Injury Research Board Postdoctoral Fellowship,No.C32633GG(to YL)。

摘　　要：Therapeutic intervention for spinal cord injury is limited,with many approaches relying on strengthening the remaining substrate and driving recovery through rehabilitative training.As compared with learning novel compensatory strategies,rehabilitation focuses on resto ring movements lost to injury.Whether rehabilitation of previously learned movements after spinal cord injury requires the molecular mechanisms of motor learning,or if it engages previously trained motor circuits without requiring novel learning remains an open question.In this study,mice we re randomly assigned to receive intrape ritoneal injection with the pan-nicotinic,non-competitive antagonist mecamylamine and the nicotinicα7 subunit selective antagonist methyllycaconitine citrate salt or vehicle(normal saline)prior to motor learning assays,then randomly reassigned after motor learning for rehabilitation study post-injury.Ce rvical spinal co rd dorsal column lesion was used as a model of in complete injury.Results of this study showed that nicotinic acetylcholine signaling was required for motor learning of the single pellet-reaching task but it was dispensable for the rehabilitation of the same task after injury.Our findings indicate that critical diffe rences exist between the molecular mechanisms supporting compensatory motor learning strategies and the restoration of behavior lost to spinal cord injury.

关 键 词：ACETYLCHOLINE basal forebrain corticospinal tract dorsal column lesion mecamylamine METHYLLYCACONITINE motor control REHABILITATION ROTAROD single pellet-reaching task 

分 类 号：R651.2[医药卫生—外科学]