Targeting the cholinergic system in Parkinson’s disease  

作　　者：Changliang Liu 

机构地区：[1]Department of Neurobiology,Harvard Medical School,Boston,02115 MA,USA

出　　处：《Acta Pharmacologica Sinica》2020年第4期453-463,共11页中国药理学报（英文版）

基　　金：supported by the Gordon Fellowship from Harvard Medical School(to Changliang Liu).

摘　　要：Motor control in the striatum is an orchestra played by various neuronal populations.Loss of harmony due to dopamine de?ciency is considered the primary pathological cause of the symptoms of Parkinson’s disease(PD).Recent progress in experimental approaches has enabled us to examine the striatal circuitry in a much more comprehensive manner,not only reshaping our understanding of striatal functions in movement regulation but also leading to new opportunities for the development of therapeutic strategies for treating PD.In addition to dopaminergic innervation,giant aspiny cholinergic interneurons(ChIs)within the striatum have long been recognized as a critical node for balancing dopamine signaling and regulating movement.With the roles of ChIs in motor control further uncovered and more speci?c manipulations available,striatal ChIs and their corresponding receptors are emerging as new promising therapeutic targets for PD.This review summarizes recent progress in functional studies of striatal circuitry and discusses the translational implications of these new?ndings for the treatment of PD.

关 键 词：Parkinson’s disease motor control ACETYLCHOLINE DOPAMINE NICOTINIC receptor 

分 类 号：R742.5[医药卫生—神经病学与精神病学]