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Tau(t)ing glucocorticoid binding
《Cell Research》2025年第1期1-2,共2页Sabine Vettorazzi Jan Tuckermann 
Glucocorticoids are two-faced drugs:they have beneficial antiinflammatory effects but,on the other hand,trigger complications like osteoporosis;identifying glucocorticoid-mediated pathways responsible for side effects...
关键词：GLUCOCORTICOID DRUGS CORNERS 
Natural product mediated mesenchymaleepithelial remodeling by covalently binding ENO1 to degrade m6A modified b-catenin mRNA
《Acta Pharmaceutica Sinica B》2025年第1期467-483,共17页Tianyang Chen Guangju Liu Sisi Chen Fengyuan Zhang Shuoqian Ma Yongping Bai Quan Zhang Yahui Ding 
support of the National Natural Science Foundation of China(Nos.81872764 and 82273808 to Quan Zhang and No.82272654 to Yahui Ding).
The transition of cancer cells from epithelial state to mesenchymal state awarded hepatocellular carcinoma(HCC)stem cell properties and induced tumorigenicity,drug resistance,and high recurrence rate.Reversing the mes...
关键词：Natural product Target identification ENO1 Mesenchymal-epithelial remodeling Β-CATENIN 
Halogen-assisted octet binding electrons construction of pnictogens towards wide-bandgap nonlinear optical pnictides
《Chinese Chemical Letters》2024年第12期557-560,共4页Lihua Gao Yinglei Han Chensheng Lin Huikang Jiang Guang Peng Guangsai Yang Jindong Chen Ning Ye 
supported by the National Natural Science Foundation of China(Nos.22305174,22375147,52332001,51890862,51902308 and 21921001);the Natural Science Foundation of Fujian Province(No.2021J05097);the Natural Science Foundation of Tianjin City(No.22JCYBJC01380)。
The design of pnictide nonlinear optical crystals is quite different from chalcogenide and oxide those in which a new paradigm need be developed to regulate the band gap,one of key optical parameters In this work,two ...
关键词：Nonlinear optical crystal Halidepnictide Wide band gap Structure design Electronic structure 
Synthesis,crystal structure,and DNA‑binding of binuclear lanthanide complexes based on a multidentate Schiff base ligand
《无机化学学报》2024年第12期2486-2496,共11页GUAN Xiaofen LIU Yating LI Jia HU Yiwen DING Haiyuan SHI Yuanjing WANG Zhiqiang WANG Wenmin 
山西省应用基础研究基金(No.202303021212256)资助。
Two new dinuclear lanthanidecomplexes,namely[Ln_(2)(dbm)_(2)(HL)_(2)(CH_(3)OH)_(2)]·4CH_(3)OH[Ln=Tb(1)and Dy(2),Hdbm=dibenzoylmethane]have been synthesized using prepared multidentate Schiff base ligand H_(3)L(hydrox...
关键词：binuclear lanthanide complexes crystal structures multidentate Schiff base DNA INSERTION 
Modulating the Binding of Metal Centers with Reaction Intermediates to Boost Photocatalytic CO_(2)Reduction
《CCS Chemistry》2024年第12期2961-2970,共10页Ji-Hong Zhang Hong-Juan Wang Wen-Jie Shi Wei Yang Jian-Hua Mei Yu-Chen Wang Tong-Bu Lu Di-Chang Zhong 
the National Key R&D Program of China(grant no.2022YFA1502902);the National Natural Science Foundation of China(NSFC;grant nos.22271218 and 22071182);the Natural Science Foundation of Tianjin City,China(grant no.23JCQNJC00570);the Tianjin University of Technology Innovation Project for Postgraduate Students,China(grant no.YJ2233);the Tianjin Research Innovation Project for Postgraduate Students,China(grant no.2022BKY155).
It is a consensus that the process involving photocatalytic CO_(2)reduction to CO undergoes a*COOH/*CO pathway,in which the binding of the catalytic centers with the*COOH/*CO reaction intermediates greatly influences ...
关键词：homogeneous catalysis CO_(2)reduction PHOTOCATALYSIS moderate binding coordination environment 
Peptide Cy_(RL-QN15)accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor
《Zoological Research》2024年第6期1287-1299,共13页Yu-Tong Wu Ze-Qiong Ru Ying Peng Zhe Fu Qiu-Ye Jia Zi-Jian Kang Yuan-Sheng Li Yu-Bing Huang Sai-Ge Yin Kun Guo Nai-Xin Liu Cheng-An Feng Jing Tang Bai-Yu Zhang Zhi Yang Ying Wang Xin-Wang Yang 
supported by the Key Program of Yunnan Applied Basic Research Project(202301AS070036);Outstanding Youth Program of Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(202301AY070001-301);First-Class Discipline Team of Skin&Mucosal Regenerative Medicine of Kunming Medical University(2024XKTDTS10);National Natural Science Foundation of China(32360138,32301054,32060212,82371567);Program of Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(202301AY070001-012,202101AY070001-006,202301AY070001-198,202101AY070001-035,202101AY070001-036,202401AY070001-028,202401AY070001-068)。
Individuals with diabetes frequently face serious challenges,including delayed wound healing and increased risk of infection.Notably,the regeneration of hair follicles plays a crucial role in accelerating diabetic ski...
关键词：CyRL-QN15 Hair follicle stem cells(HFSCs) Β-CATENIN Frizzled-7 
Structural basis of tolvaptan binding to the vasopressin V_(2)receptor
《Acta Pharmacologica Sinica》2024年第11期2441-2449,共9页Hong-li Liu Hai-yang Zhong Yi-xiao Zhang Hua-rui Xue Zheng-shuo Zhang Ke-quan Fu Xu-dong Cao Xiao-chun Xiong Dong Guo 
supported by the National Natural Science Foundation of China(22377103,22107090 and 22077110);the Natural Science Foundation of Jiangsu Province(BK20200106);the Major Basic Research Project of the Natural Science Research Foundation of the Jiangsu Higher Education Institutions(20KJA350001);the Natural Science Research Project of Jiangsu Universities(21KJB350009);the Scientific Research Foundation for Talented Scholars in Xuzhou Medical University(D2020036,D2022002).
The vasopressin V_(2)receptor(V_(2)R)is a validated therapeutic target for autosomal dominant polycystic kidney disease(ADPKD),with tolvaptan being the first FDA-approved antagonist.Herein,we used Gaussian accelerated...
关键词：vasopressin V_(2)receptor(V_(2)R) TOLVAPTAN binding pathway gaussian accelerated molecular dynamics(GaMD)simulations 
Chalcogenoviologen Enhanced Host–Guest Recognition
《CCS Chemistry》2024年第11期2679-2691,共13页Yuanning Feng Xingang Zhao Daniel A.Appleton Han Han Ryan M.Young Wenqi Liu Christopher K.Lee Weixingyue Li Bai-Tong Liu Yong Wu Chun Tang Aspen X-Y.Chen Charlotte L.Stern Dong Jun Kim Michael R.Wasielewski Yunyan Qiu J.Fraser Stoddart 
supported by the US Department of Energy,Office of Science,Office of Basic Energy Sciences,under Award DE-FG02-99ER14999(M.R.W.);This research made use of the Integrated Molecular Structure Education and Research Center NMR,MS,and X-ray facility at NU,which receives support from the Soft and Hybrid Nanotechnology Experimental(SHyNE)Resource(NSF ECCS-2025633)and NU(C.L.S.).
In the field of supramolecular chemistry,cyclophanes with novel properties are highly sought after since they can be tailored to fulfill specific tasks.In this article,we incorporate chalcogenoviologen-based units int...
关键词：binding titrations CHALCOGENS host–guest systems molecular recognition supramolecular chemistry 
Potential regulatory mechanism and clinical significance of synaptotagmin binding cytoplasmic RNA interacting protein in colorectal cancer
《World Journal of Clinical Oncology》2024年第11期1412-1427,共16页Hui Li He-Qing Huang Zhi-Guang Huang Rong-Quan He Ye-Ying Fang Rui Song Jia-Yuan Luo Da-Tong Zeng Kai Qin Dan-Ming Wei Gang Chen 
Supported by Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project,No.Z-A20220415 and No.Z20210442;The First Affiliated Hospital of Guangxi Medical University Provincial and Ministerial Key Laboratory Cultivation Project:Guangxi Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer,No.21-220-18.
BACKGROUND Colorectal cancer(CRC)causes many deaths worldwide.Synaptotagmin binding cytoplasmic RNA interacting protein(SYNCRIP)is an RNA-binding protein that plays an important role in multiple cancers by epigenetica...
关键词：Synaptotagmin binding cytoplasmic RNA interacting protein Colorectal cancer Radiotherapy Cell mitosis Immune microenvironment 
Rack1 regulates B-cell development and function by binding to and stabilizing the transcription factor Pax5
《Cellular & Molecular Immunology》2024年第11期1282-1295,共14页Xueting Zhang Chenke Ma Yuchen Lu Jing Wang Hongfang Yun Hui Jiang Mengyao Wu Xiaoyao Feng Wenbin Gai Guanglei Xu Hongbin Deng Jiannan Feng Wanli Liu Taoxing Shi Qianqian Cheng Jiyan Zhang 
supported by grants from the National Natural Science Foundation of China(81930027,92169207,and 82172298).
The transcription factor Pax5 activates genes essential for B-cell development and function.However,the regulation of Pax5 expression remains elusive.The adaptor Rack1 can interact with multiple transcription factors ...
关键词：RACK1 PAX5 UBIQUITINATION B-cell development BCR signaling 
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