supported by grants from the National Natural Science Foundation of China(81930027,92169207,and 82172298).
The transcription factor Pax5 activates genes essential for B-cell development and function.However,the regulation of Pax5 expression remains elusive.The adaptor Rack1 can interact with multiple transcription factors ...
National Science Foundation of China(NSFC Nos.31671298,81802390,and 81672462);Natural Science Foundation of Beijing(No.7202187);National Key Research and Development Program of China(Nos.2016YFC0905200,2016YFC0905302,and 2017YFC 1308900);National Geriatrics Center Funding(No.NCRCG-PLAGH-2018002);Key Projects of Clinical Application and Promotion with Capital Characteristics(No.Z161100000516003);Military Medical Special Program for Youth of Chinese People's Liberation Army General Hospital(No.QNF19037)。
Background:Gene promoter methylation is a major epigenetic change in cancers,which plays critical roles in carcinogenesis.As a crucial regulator in the early stages of B-cell differentiation and embryonic neurodevelop...