CHEMOSENSITIVITY

作品数：127被引量：532H指数：14
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TULP4 degrades RYBP to enhance DNA damage repair and chemosensitivity of pancreatic ductal adenocarcinoma
《Genes & Diseases》2025年第2期41-44,共4页Jingyao Dai Su Liu Yangyang Xie Yixuan Wang Xiyun Bian Tian Yu Tiantian Li Linchuang Jia Zhigang Zhao Zhiqiang Liu Xiaozhi Liu 
the Ethics Committee of the Fifth Central Hospital of Tianjin (No.TJWZXLL2022034).
Gemcitabine is widely used in the treatment of pancreatic ductal adenocarcinoma(PDAC),but the development of chemoresistance poses a significant challenge to achieving long-term disease-free survival in PDAC patients....
关键词：DAMAGE METABOLISM ADENOCARCINOMA 
Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer
《World Journal of Clinical Oncology》2025年第2期63-75,共13页Xu-Fan Zhang Qian Chen Qin Jiang Qiong-Ying Hu 
BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC patients.Although therapy may initially yield positive...
关键词：SH-4-54 Colorectal cancer Cancer stem-like cells STEMNESS CHEMOSENSITIVITY 
Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module
《Acta Pharmacologica Sinica》2024年第12期2657-2671,共15页Xiao-ju Shen Hui-lan Wei Xiao-cheng Mo Xiao-xiang Mo Li Li Jing-chuan He Xin-yu Wei Xiao-jun Qin Shang-ping Xing Zhuo Luo Zhi-quan Chen Jie Yang 
supported by National Natural Science Foundation of China(82374093);Joint Project on Regional High-lncidence Diseases Research of Guangxi Natural Science Foundation under Grant No.2023GXNSFDA026026;National Natural Science Foundation of China(82160698);Joint Project on Regional High-lncidence Diseases Research of Guangxi Natural Science Foundation under Grant No.2024GXNSFBA010027;Guangxi Natural Science Foundation(No.2022GXNSFBA035652);The Science and Technology Planning Project of Nanning Qingxiu District(No:2021013);the Guangxi Medical University Training Program for Distinguished Young Scholars,and the Guangxi First-class Discipline Project for Pharmaceutical Sciences(No.GXFCDP-PS-2018)。
Small cell lung cancer(SCLC)is a recalcitrant malignancy with dismal prognosis due to rapid relapse after an initial treatment response.More effective treatments for SCLC are desperately needed.Our previous studies sh...
关键词：small cell lung cancer CEMIP adaptor protein SRC YAP chemotherapy sensitivity 
Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma
《Acta Pharmacologica Sinica》2024年第11期2420-2431,共12页Xiao Fang Wen-ying Yu Chun-miao Zhu Nan Zhao Wei Zhao Ting-ting Xie Li-jie Wei Xi-ran Sun Juan Xie Ya Zhao 
support of the“Youth Talent Support Program”from Yangzhou University.This work was supported by the National Natural Science Foundation of China(81972251 to XF and 32170552 to YZ);Natural Science Research of Jiangsu Higher Education Institutions of China(23KJA310012 to XF and 21KJA180001 to YZ);the Jiangsu Provincial Medical Key Discipline Cultivation Unit(JSDW202251).
Chromosome instability(CIN)and subsequent aneuploidy are prevalent in various human malignancies,influencing tumor progression such as metastases and relapses.Extensive studies demonstrate the development of chemoresi...
关键词：colorectal carcinoma chromosome instability CHEMOSENSITIVITY BCL-XL Navitoclax WEHI-539 
A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells
《Oncology Research》2024年第5期817-830,共14页SHAHID KARIM ALANOUD NAHER ALGHANMI MAHA JAMAL HUDA ALKREATHY ALAM JAMAL HIND A.ALKHATABI MOHAMMED BAZUHAIR AFTAB AHMAD 
funded by the Deanship of Scientific Research(DSR),King Abdulaziz University,Jeddah,Saudi Arabia,under Grant No.KEP-1-166-41;The authors,therefore,acknowledge DSR,with thanks for their technical and financial support.
Cancer frequently develops resistance to the majority of chemotherapy treatments.This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors,specifically Canagliflozin(CAN),Dapaglif...
关键词：SGLT2 Cancer CYTOTOXICITY ATP Cell cycle 
miR-34b-3p-mediated regulation of STC2 and FN1 enhances chemosensitivity and inhibits proliferation in cervical cancer
《Acta Biochimica et Biophysica Sinica》2024年第5期740-752,共13页Shanshan Jin Wenting Wang Xinrui Xu Zhaowei Yu Zihan Feng Jun Xie Huimin Lv 
supported by the grants from the Applied Basic Research Programs of Science and Technology Commission Foundation of Shanxi Province(No.20210302124592);the Scientific Research Project of Health Commission of Shanxi Province(No.2021151).
Dysregulation of microRNA(miRNA)expression in cancer is a significant factor contributing to the progression of chemoresistance.The objective of this study is to explore the underlying mechanisms by which miR-34b-3p r...
关键词：miR-34b-3p CHEMORESISTANCE cervical cancer stanniocalcin 2(STC2) fibronectin 1(FN1) CISPLATIN 
Multiple Potential Markers of Chemosensitivity of Ovarian Cancer, Among Which KELIM of CA125 Is Low Cost and Efficient
《Journal of Biosciences and Medicines》2024年第2期257-273,共17页Huilin Tu Zhe Wang Luya Cai Xiaoxu Zhu Jianhua Qian 
Aim: Ovarian cancer (OC) is a malignant cancer with the highest death rate among various kinds of gynecological tumors. The treatment pattern of HGSCs is mainly primary debulking surgery (PDS), followed by platinum-ba...
关键词：Epithelial Cancer of the Ovary Chemotherapy in GYN Cancers 
Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway被引量：1
《Genes & Diseases》2024年第1期430-448,共19页Jun Fan Zhe Zhang Hongqiang Chen Dongjiao Chen Wenbo Yuan Jingzhi Li Yong Zeng Shimeng Zhou Shu Zhang Gang Zhang Jiashen Xiong Lu Zhou Jing Xu Wenbin Liu Yan Xu 
supported by the National Natural Science Foundation of China(No.81472482,82173556);the Clinical Technology Innovation and Cultivation Project of the Army Medical University of China(No.CX2019LC120);the National Key Clinical Specialty Military Construction Project(China,No.425Z8).
Emerging evidence suggested that zinc finger protein 831(ZNF831)was associated with immune activity and stem cell regulation in breast cancer.Whereas,the roles and molec-ular mechanisms of ZNF831 in oncogenesis remain...
关键词：Apoptosis Breast cancer CHEMOSENSITIVITY STAT3 ZNF831 
Targeting P21-activated kinase suppresses proliferation and enhances chemosensitivity in T-cell lymphoblastic lymphoma
《Blood Science》2023年第4期249-257,共9页Ning Su Yu Fang Xu Chen Xiaoqin Chen Zhongjun Xia Huiqiang Huang Yi Xia Panpan Liu Xiaopeng Tian Qingqing Cai 
supported by grants from the National Key Research and Development Program(No.2022YFC2502602 to Dr.Q.C.);the National Natural Science Foundation project(Nos.82230001 and 82270199 to Dr.Q.C.,No.81973384 to Dr.X.T.);the Medical Research Foundation of Guangdong Province(No.A2023488 to Dr.Y.F.).
T-cell lymphoblastic lymphoma(T-LBL)is a highly aggressive non-Hodgkin lymphoma with a poor prognosis.P21-activated kinase(PAK)is a component of the gene expression-based classifier that can predict the prognosis of T...
关键词：P21-activated kinase PAK inhibitor PROLIFERATION RELAPSE T-cell lymphoblastic lymphoma 
Deltonin enhances gastric carcinoma cell apoptosis and chemosensitivity to cisplatin via inhibiting PI3K/AKT/mTOR and MAPK signaling
《World Journal of Gastrointestinal Oncology》2023年第10期1739-1755,共17页Lin Yang Ya-Nan Liu Yi Gu Qi Guo 
BACKGROUND As an active ingredient derived from Dioscorea zingiberensis C.H.Wright,deltonin has been reported to show anti-cancer effects in a variety of malignancies.AIM To investigate the role and mechanism of actio...
关键词：Deltonin Gastric carcinoma CISPLATIN Apoptosis Chemotherapy Axis 
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