TOLVAPTAN

作品数：33被引量：77H指数：4
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相关领域：医药卫生更多>>
相关作者：邱飞王礼琛卢永昕苏淑芳更多>>
相关机构：中国药科大学华中科技大学沈阳药科大学更多>>
相关期刊：《World Journal of Clinical Cases》《Open Journal of Gastroenterology》《China Medical Abstracts(Internal Medicine)》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金更多>>
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Structural basis of tolvaptan binding to the vasopressin V_(2)receptor
《Acta Pharmacologica Sinica》2024年第11期2441-2449,共9页Hong-li Liu Hai-yang Zhong Yi-xiao Zhang Hua-rui Xue Zheng-shuo Zhang Ke-quan Fu Xu-dong Cao Xiao-chun Xiong Dong Guo 
supported by the National Natural Science Foundation of China(22377103,22107090 and 22077110);the Natural Science Foundation of Jiangsu Province(BK20200106);the Major Basic Research Project of the Natural Science Research Foundation of the Jiangsu Higher Education Institutions(20KJA350001);the Natural Science Research Project of Jiangsu Universities(21KJB350009);the Scientific Research Foundation for Talented Scholars in Xuzhou Medical University(D2020036,D2022002).
The vasopressin V_(2)receptor(V_(2)R)is a validated therapeutic target for autosomal dominant polycystic kidney disease(ADPKD),with tolvaptan being the first FDA-approved antagonist.Herein,we used Gaussian accelerated...
关键词：vasopressin V_(2)receptor(V_(2)R) TOLVAPTAN binding pathway gaussian accelerated molecular dynamics(GaMD)simulations 
Plasma copeptin concentration is a predictor of tolvaptan efficacy in patients with hepatic ascites
《Portal Hypertension & Cirrhosis》2023年第3期109-114,共6页Fumimasa Tomooka Kei Moriya Takahiro Kubo Akihiko Shibamoto Jyunya Suzuki Satoshi Iwai Soichi Takeda Yuki Fujimoto Masahide Enomoto Koji Murata Yuki Tsuji Yukihisa Fujinaga Koh Kitagawa Norihisa Nishimura Hiroaki Takaya Kosuke Kaji Hideto Kawaratani Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji 
Aims:No solid evidence-based opinion was raised regarding predictors of the degree of ascites reduction with tolvaptan.This retrospective cohort study aimed to examine whether serum copeptin concentration is a useful ...
关键词：ASCITES COPEPTIN decompensated liver cirrhosis DIURETICS TOLVAPTAN 
Efficacy of tolvaptan in an infant with syndrome of inappropriate antidiuretic hormone secretion associated with holoprosencephaly:A case report
《World Journal of Clinical Cases》2023年第26期6262-6267,共6页Mari Mori Satoru Takeshita Nami Nakamura Yuki Mizuno Akiko Tomita Mineyoshi Aoyama Hiroki Kakita Yasumasa Yamada 
BACKGROUND Holoprosencephaly(HPE)is a congenital malformation with various degrees of incomplete separation of the cerebral hemispheres due to differentiation disorders of the forebrain.Although HPE with diabetes insi...
关键词：TOLVAPTAN HOLOPROSENCEPHALY Antidiuretic hormone Syndrome of inappropriate secretion of antidiuretic hormone HYPONATREMIA Case report 
The Efficacy and Safety of Tolvaptan in Heart Failure Patients with Congestive Signs:A Systematic Review and Meta-Analysis of Randomized Controlled Trials
《Cardiology Discovery》2023年第1期30-39,共10页Mei Zeng Na Li Tongshuai Chen Yun Ti Chunmei Zhang Peili Bu 
the State Key Program of National Natural Science Foundation of China(81530014);National Key R&D Plan of China(2017YFC1700502);National Natural Science Foundation for Young Scientists of China(81700366).
Objective:The aim of this study was to investigate the efficacy and safety of tolvaptan,as well as the impact of its treatment dose and duration in heart failure patients with congestive signs.Methods:The PubMed,Embas...
关键词：Heart failure TOLVAPTAN CONGESTION META-ANALYSIS Randomized controlled trials 
Tolvaptan ameliorated kidney function for one elderly autosomal dominant polycystic kidney disease patient: A case report
《World Journal of Clinical Cases》2022年第31期11500-11507,共8页Li Zhou Yan Tian Liang Ma Wen-Ge Li 
BACKGROUND Polycystic kidney disease(PKD)is a genetic disorder characterized by the growth of numerous cysts within the kidneys.Disease progress of some patients often occurs at the early stage.Thus,managing and contr...
关键词：Chronic kidney disease Autosomal dominant polycystic kidney disease Deep vein thrombosis TOLVAPTAN Case report 
Efficacy of Tolvaptan in elderly chronic heart failure patients combined with mild to moderate renal insufficiency with hyponatremia
《China Medical Abstracts(Internal Medicine)》2021年第2期102-102,共1页XU Xianjing 
Objective To evaluate the efficacy and safety of conventional diuretic therapy versus Tolvaptan in elderly chronic heart failure patients combined with mild to moderate renal insufficiency with hyponatremia,in order t...
关键词：INSUFFICIENCY PATIENTS clinical 
Tolvaptan,an FDA-approved drug,inhibits Zika virus infection both in vitro and in vivo
《Journal of Chinese Pharmaceutical Sciences》2021年第3期218-229,共12页Xiuxiu Chen Ronghua Luo Zhaiwen Yao Changbo Zheng Qiuju Tang Wei Pang Fang Wang Liumeng Yang Sidong Xiong Yongtang Zheng 
National Key R&D Program of China(Grant No.2016YFC1201000);the Key Deployment Projects of the Chinese Academy of Sciences(Grant No.ZDRW-ZS-2016-4-2);the Key Laboratory of Bioactive Peptides of Yunnan Province(Grant No.AMHD-2017-3).
As a previously neglected member of flavivirus,Zika virus(ZIKV)has recently emerged and caused a global health concern because of its link to microcephaly and other congenital defects.Currently,no anti-ZIKV vaccine or...
关键词：Zika virus TOLVAPTAN ANTIVIRAL MICROCEPHALY FLAVIVIRUS 
Acute Effects of Tolvaptan on Renal Hemodynamics in Autosomal Dominant Polycystic Kidney Disease —A Randomized, Cross-Over, Double Blind, Placebo-Controlled Study of Renal Plasma Flow and Glomerular Filtration Rate
《Open Journal of Nephrology》2019年第4期97-114,共18页My Helbo Malmberg Frank Holden Mose Rikke Lund Sonderbaek June Anita Ejlersen Jens Jorgen Jensen Erling Bjerregaard Pedersen Jesper Norgaard Bech 
Background: Previous studies have shown that reduced renal plasma flow (RPF) may play a role in progression of renal disease in autosomal dominant polycystic kidney disease (ADPKD). Tolvaptan, a vasopressin 2 antagoni...
关键词：Autosomal Dominant Polycystic Kidney Disease Renal Plasma Flow Glomerular Filtration Rate RENOGRAPHY Brachial Blood Pressure Central Blood Pressure VASOPRESSIN RENIN Angiotensin II ALDOSTERONE 
Tolvaptan attenuates atrial remodeling in rats undergoing chronic intermittent hypoxia via miRNA-21
《China Medical Abstracts(Internal Medicine)》2019年第4期211-212,共2页MA Zuowang 
Objective To investigate the effects and potential mechanisms of tolvaptan on chronic intermittent hypoxia(CIH)-induced atrial remodeling in rats.Methods A total of 45 Sprague-Dawley rats were divided into 3 groups by...
关键词：MIRNA ERK TOLVAPTAN 
The Effect of Loop Diuretics on Sarcopenia and Long-Term Prognosis in Patients with Refractory Hepatic Ascites Treated with Tolvaptan
《Open Journal of Gastroenterology》2018年第6期201-208,共8页Masaaki Shimada Hiroaki Iwase Noboru Hirashima Masashi Saito Hisashi Kondo Noboru Urata Satoshi Unita Takashi Kondo Daiki Tanaka Takuya Tsunekawa 
We investigated sarcopenia, focusing on the dose of loop diuretics used in 70 patients with refractory hepatic ascites treated with tolvaptan. Bloating improved in 68.5% of patients, as determined using the Japanese v...
关键词：TOLVAPTAN HEPATIC ASCITES SARCOPENIA Loop DIURETICS Long-Term Prognosis 
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