MICROCEPHALY

作品数：46被引量：50H指数：4
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相关机构：福州大学更多>>
相关期刊：《Chinese Medical Journal》《Advances in Microbiology》《Open Journal of Ophthalmology》《Acta Epileptologica》更多>>
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Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model
《Journal of Genetics and Genomics》2024年第4期419-432,共14页Qing Yang Qiang Cao Yue Yu Xianxin Lai Jiahao Feng Xinjie Li Yinan Jiang Yazhou Sun Zhong-Wei Zhou Xin Li 
supported by the National Natural Science Foundation of China(81872299 to X.L.and 3217070538 to W.Z.Z.);Shenzhen Science and Technology Program(JCYJ20190807160011600 and JCYJ20210324124808023 to X.L.;JCYJ20200109142446804,JCYJ20220530145807018,ZDSYS20220606100803007,and JCYJ20190807154407467 to W.Z.Z.);Guangdong Provincial Key Laboratory of Digestive Cancer Research(2021B1212040006 to X.L.),and China Postdoctoral Science Foundation(2020M683073 to Y.Z.S.).
The cerebral cortex is a pivotal structure integral to advanced brain functions within the mammalian central nervous system.DNA methylation and hydroxymethylation play important roles in regulating cerebral cortex dev...
关键词：MICROCEPHALY Epigeneticmodification Tet1 Cerebral cortexdevelopment DNA hydroxymethylome TRANSCRIPTOME 
Biallelic mutations in UGDH cause congenital microcephaly
《Genes & Diseases》2023年第5期1816-1819,共4页Li Shu Guangyao Xie Daoqi Mei Rui Xu Shixian Liu Bo Xiao Xing Li Yuanyuan Xie Xiao Mao Hua Wang 
supported by the Natural Science Foundation of Hunan Province,China(No.2021JJ40280);the National Key Research and Development Program of China(No.2021YFC1005300);the Major Scientific and Technological Projects for Collaborative Prevention and Control of Birth Defects in Hunan Province,China(No.2019SK1010,2019SK1014);the National Key R&D Program of China(No.2019YFC1005100);the Hunan Provincial Science and Technology Department(China)(No.2018SK2064);the Joint Construction Project of Henan Medical Science and Technology Project(China)(No.LHGJ20200618,2018020633);the Henan Engineering Research Center of Childhood Neurodevelopment Open Project(China)(No.SG201907).
Hengel et al recently reported that bi-allelic loss-of-function mutations in UDP-Glucose 6-Dehydrogenase(UGDH)caused a severe epileptic encephalopathy syndrome-Jamuar syndrome(OMIM#618792).1 The functional studies par...
关键词：CONGENITAL CEREBRAL PATIENTS 
WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice
《Neuroscience Bulletin》2023年第9期1333-1347,共15页Dan Xu Yiqiang Zhi Xinyi Liu Le Guan Jurui Yu Dan Zhang Weiya Zhang Yaqing Wang Wucheng Tao Zhiheng Xu 
This work was supported by the National Natural Science Foundation of China(31970920,31921002,and 31430037).
Brain size abnormality is correlated with an increased frequency of autism spectrum disorder(ASD)in offspring.Genetic analysis indicates that heterozygous mutations of the WD repeat domain 62(WDR62)are associated with...
关键词：WDR62 MICROCEPHALY Autism spectrum disorder SYNAPSE Retinoic acid 
Consanguinity and Occurrence of Genetic Disorders in District Attock
《China-USA Business Review》2023年第1期20-27,共8页Ummara Rafi Sohail Hameed Naheed Malik Mariam Awan Shahid Baig Uzma Abdullah 
Consanguineous marriages are the marriages between blood relatives;nevertheless,it can also be referred as unions between second cousins or closer by the geneticists.Consanguinity increases the risk of congenital anom...
关键词：CONSANGUINITY NDM(Neuromuscular Disorder) MR(Mental Retardation) MICROCEPHALY EPILEPSY ICHTHYOSIS 
Growth hormone attenuates the brain damage caused by ZIKV infection in mice
《Virologica Sinica》2022年第4期601-609,共9页Zi-Da Zhen Na Wu Dong-Ying Fan Jun-Hong Ai Zheng-Ran Song Jia-Tong Chang Pei-Gang Wang Yan-Hua Wu Jing An 
the grants from the National Key Research and Development Plan of China(2021YFC2300200);the National Natural Science Foundation of China(NSFC)(U1902210 and 81972979 to J.An,and 82172266 to P.G.Wang);Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Fiveyear Plan(IDHT20190510 to J.An)。
As a member of vector-borne viruses,Zika virus(ZIKV)can cause microcephaly and various neurological symptoms in newborns.Previously,we found that ZIKV could infect hypothalamus,causing a decrease in growth hormone(GH)...
关键词：Zika virus(ZIKV) Growth hormone APOPTOSIS MICROCEPHALY 
Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study
《Reproductive and Developmental Medicine》2022年第2期98-103,共6页Juliana Herrero da Silva Ana Claudia Pereira Tercas-Trettel Juliano Andre Boquett Giovanny Vinicius Araujo Franca Augusto Cesar Cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia Nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini 
INAGEMP-National Institute of Population Medical Genetics grant CNPq(465549/2014-4);CAPES(88887.136366/2017-00);FAPERGS(17/2551-0000521-0);Project: Zika vírus: Uma abordagem translacional(CNPq grant 440763/2016-9);Project: A História Natural do Zika Vírus(Ministry of Health grant 929698560001160-02)
Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephal...
关键词：EPIDEMIOLOGY Live births MICROCEPHALY Zika virus 
Zika Virus and Its Association with Neurological Disorders
《Advances in Microbiology》2022年第4期198-217,共20页Dama Faniriantsoa Henrio Marcellin Limin Guo Haiyang Yu Shuchao Wang Paul Pielnaa Adonira Saro Ismail Bilal Masokano Malik Muhammad Adil Ling Yuan Yanxia Huang Deyang Cai Ruping Zheng Zhongjun Huang Aixiang Luo Cyrollah Disoma Pinjia Liu Zanxian Xia Jufang Huang 
Zika virus (ZIKV) is a flavivirus that can be identified as a small envelope with a positive-stranded RNA and an important medical pathogen, which causes deadly human diseases. The virus is carried by Aedes aegypti mo...
关键词：Zika Virus (ZIKV) MICROCEPHALY Guillain Barré Syndrome EPILEPSY Neurological Disorders 
Tolvaptan,an FDA-approved drug,inhibits Zika virus infection both in vitro and in vivo
《Journal of Chinese Pharmaceutical Sciences》2021年第3期218-229,共12页Xiuxiu Chen Ronghua Luo Zhaiwen Yao Changbo Zheng Qiuju Tang Wei Pang Fang Wang Liumeng Yang Sidong Xiong Yongtang Zheng 
National Key R&D Program of China(Grant No.2016YFC1201000);the Key Deployment Projects of the Chinese Academy of Sciences(Grant No.ZDRW-ZS-2016-4-2);the Key Laboratory of Bioactive Peptides of Yunnan Province(Grant No.AMHD-2017-3).
As a previously neglected member of flavivirus,Zika virus(ZIKV)has recently emerged and caused a global health concern because of its link to microcephaly and other congenital defects.Currently,no anti-ZIKV vaccine or...
关键词：Zika virus TOLVAPTAN ANTIVIRAL MICROCEPHALY FLAVIVIRUS 
Novel mutation in the ASXL3 gene in a Chinese boy with microcephaly and speech impairment:A case report被引量：5
《World Journal of Clinical Cases》2020年第24期6465-6472,共8页Jin-Rong Li Zhuo Huang You Lu Qiao-Yun Ji Ming-Yan Jiang Fan Yang 
Supported by the Health andFamily Planning Commission ofSichuan Province, No. 150106.
BACKGROUND Bainbridge-Ropers syndrome (BRPS) is a severe disorder characterized by failureto thrive, facial dysmorphism, and severe developmental delay. BRPS is caused bya heterozygous loss-of-function mutation in the...
关键词：Bainbridge-Ropers syndrome ASXL3 mutation Whole-exome sequencing Case report 
Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
《Genomics, Proteomics & Bioinformatics》2020年第6期737-748,共12页Yafei Chang Yisheng Jiang Cui Li Qin Wang Feng Zhang Cheng-Feng Qin Qing-Feng Wu Jing Li Zhiheng Xu 
This work was supported by the Strategic Priority Research Program and Innovation Program of the Chinese Academy of Sciences,China(Grant Nos.XDB32020100,XDA16010306,QYZDJ-SSW-SMC007,and GJHZ1827);the National Natural Science Foundation of China(Grant Nos.31730108,31430037,31571038,and 31871329);the Natural Science Foundation of Shanghai,China(Grant No.17ZR1413900).
The association of Zika virus(ZIKV)infection with microcephaly has raised alarm worldwide.Their causal link has been confirmed in different animal models infected by ZIKV.However,the molecular mechanisms underlying ZI...
关键词：Zika virus Brain development MICROCEPHALY Gene network Signaling pathway 
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