Zika Virus and Its Association with Neurological Disorders  

作　　者：Dama Faniriantsoa Henrio Marcellin Limin Guo Haiyang Yu Shuchao Wang Paul Pielnaa Adonira Saro Ismail Bilal Masokano Malik Muhammad Adil Ling Yuan Yanxia Huang Deyang Cai Ruping Zheng Zhongjun Huang Aixiang Luo Cyrollah Disoma Pinjia Liu Zanxian Xia Jufang Huang Dama Faniriantsoa Henrio Marcellin;Limin Guo;Haiyang Yu;Shuchao Wang;Paul Pielnaa;Adonira Saro;Ismail Bilal Masokano;Malik Muhammad Adil;Ling Yuan;Yanxia Huang;Deyang Cai;Ruping Zheng;Zhongjun Huang;Aixiang Luo;Cyrollah Disoma;Pinjia Liu;Zanxian Xia;Jufang Huang(Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China;Department of Radiology, Xiangya Hospital, Central South University, Changsha, China;Department of Hepatobiliary Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China;Department of Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China;Department of Cell Biology, School of Life Sciences, Central South University, Changsha, China)

机构地区：[1]Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China [2]Department of Radiology, Xiangya Hospital, Central South University, Changsha, China [3]Department of Hepatobiliary Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China [4]Department of Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China [5]Department of Cell Biology, School of Life Sciences, Central South University, Changsha, China

出　　处：《Advances in Microbiology》2022年第4期198-217,共20页微生物学（英文）

摘　　要：Zika virus (ZIKV) is a flavivirus that can be identified as a small envelope with a positive-stranded RNA and an important medical pathogen, which causes deadly human diseases. The virus is carried by Aedes aegypti mosquitoes through a blood meal and it is also spread through body fluids. ZIKV infection may present with symptoms like fever, myalgia, maculopapular rash as well as neurological sequelae, which include, microcephaly, epilepsy, and Guillain Barré syndrome (GBS). This put the virus on a scale of the public health burden of almost 87 countries. The potential threat of ZIKV infection is not completely eradicated in many countries in Africa, America, and the Western Pacific regions. There are no vaccines and treatments available to date. Since ZIKV causes microcephaly in utero by targeting neural progenitor cells, inducing apoptosis, and impairing neurodevelopment, this article hopes to evaluate the neurological disorders associated with the Zika virus infection while elucidating the current trends in the development of vaccines and drugs.Zika virus (ZIKV) is a flavivirus that can be identified as a small envelope with a positive-stranded RNA and an important medical pathogen, which causes deadly human diseases. The virus is carried by Aedes aegypti mosquitoes through a blood meal and it is also spread through body fluids. ZIKV infection may present with symptoms like fever, myalgia, maculopapular rash as well as neurological sequelae, which include, microcephaly, epilepsy, and Guillain Barré syndrome (GBS). This put the virus on a scale of the public health burden of almost 87 countries. The potential threat of ZIKV infection is not completely eradicated in many countries in Africa, America, and the Western Pacific regions. There are no vaccines and treatments available to date. Since ZIKV causes microcephaly in utero by targeting neural progenitor cells, inducing apoptosis, and impairing neurodevelopment, this article hopes to evaluate the neurological disorders associated with the Zika virus infection while elucidating the current trends in the development of vaccines and drugs.

关 键 词：Zika Virus (ZIKV) MICROCEPHALY Guillain Barré Syndrome EPILEPSY Neurological Disorders 

分 类 号：R74[医药卫生—神经病学与精神病学]