Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study  

作　　者：Juliana Herrero da Silva Ana Claudia Pereira Tercas-Trettel Juliano Andre Boquett Giovanny Vinicius Araujo Franca Augusto Cesar Cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia Nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini 

机构地区：[1]Prefeitura Municipal de Tangara da Serra,Secretaria de Saude,Vigilancia Epidemiologica,Tangara da Serra,Brazil [2]Programa de Pos-Graduacao em Genetica e Biologia Molecular,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil [3]Universidade do Estado de Mato Grosso,Tangara da Serra,Brazil [4]Programa de Pos-Graduagcao em Saude Coletiva,Universidade Federal de Mato Grosso,Cuiaba,Brazil [5]Instituto Nacional de Genetica Medica Populacional-INaGeMP,Servico de Genetica Medica,Hospital de Clinicas de Porto Alegre(HCPA),Porto Alegre,Brazil [6]Programa de Pos-Graduacao em Saude da Crianga e do Adolescente,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil [7]Secretaria de Vigilancia em Saude,Ministerio da Saude,Brasilia,Brazil [8]Laboratorio de Visualizacao Avangada e Geoinformatica(VIZLab),Programa de Pos-Graduacao em Computacao Aplicada,Universidade do Vale do Rio dos Sinos,Sao Leopoldo,Brazil [9]Programa de Pos-Graduacao em Ciencia da Informacao,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil [10]Clinica Santa Luzia,Tangara da Serra,Brazil

出　　处：《Reproductive and Developmental Medicine》2022年第2期98-103,共6页生殖与发育医学（英文版）

基　　金：INAGEMP-National Institute of Population Medical Genetics grant CNPq(465549/2014-4);CAPES(88887.136366/2017-00);FAPERGS(17/2551-0000521-0);Project: Zika vírus: Uma abordagem translacional(CNPq grant 440763/2016-9);Project: A História Natural do Zika Vírus(Ministry of Health grant 929698560001160-02)

摘　　要：Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics.Methods::Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics.Results::Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015.Conclusion::This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.

关 键 词：EPIDEMIOLOGY Live births MICROCEPHALY Zika virus 

分 类 号：R714.5[医药卫生—妇产科学]