Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model  

作　　者：Yafei Chang Yisheng Jiang Cui Li Qin Wang Feng Zhang Cheng-Feng Qin Qing-Feng Wu Jing Li Zhiheng Xu 

机构地区：[1]Department of Bioinformatics and Biostatistics,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China [2]State Key Laboratory of Molecular Developmental Biology,CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China [3]Department of Virology,State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Beijing 100071,China [4]Parkinson’s Disease Center,Beijing Institute for Brain Disorders,Beijing 100101,China [5]University of Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Genomics, Proteomics & Bioinformatics》2020年第6期737-748,共12页基因组蛋白质组与生物信息学报（英文版）

基　　金：This work was supported by the Strategic Priority Research Program and Innovation Program of the Chinese Academy of Sciences,China(Grant Nos.XDB32020100,XDA16010306,QYZDJ-SSW-SMC007,and GJHZ1827);the National Natural Science Foundation of China(Grant Nos.31730108,31430037,31571038,and 31871329);the Natural Science Foundation of Shanghai,China(Grant No.17ZR1413900).

摘　　要：The association of Zika virus(ZIKV)infection with microcephaly has raised alarm worldwide.Their causal link has been confirmed in different animal models infected by ZIKV.However,the molecular mechanisms underlying ZIKV pathogenesis are far from clear.Hence,we performed global gene expression analysis of ZIKV-infected mouse brains to unveil the biological and molecular networks underpinning microcephaly.We found significant dysregulation of the sub-networks associated with brain development,immune response,cell death,microglial cell activation,and autophagy amongst others.We provided detailed analysis of the related complicated gene networks and the links between them.Additionally,we analyzed the signaling pathways that were likely to be involved.This report provides systemic insights into not only the pathogenesis,but also a path to the development of prophylactic and therapeutic strategies against ZIKV infection.

关 键 词：Zika virus Brain development MICROCEPHALY Gene network Signaling pathway 

分 类 号：R511[医药卫生—内科学]