Growth hormone attenuates the brain damage caused by ZIKV infection in mice  

作　　者：Zi-Da Zhen Na Wu Dong-Ying Fan Jun-Hong Ai Zheng-Ran Song Jia-Tong Chang Pei-Gang Wang Yan-Hua Wu Jing An 

机构地区：[1]Department of Microbiology,School of Basic Medical Sciences,Capital Medical University,Beijing,100069,China [2]Laboratory Animal Resource Center,Capital Medical University,Beijing,100069,China

出　　处：《Virologica Sinica》2022年第4期601-609,共9页中国病毒学（英文版）

基　　金：the grants from the National Key Research and Development Plan of China(2021YFC2300200);the National Natural Science Foundation of China(NSFC)(U1902210 and 81972979 to J.An,and 82172266 to P.G.Wang);Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Fiveyear Plan(IDHT20190510 to J.An)。

摘　　要：As a member of vector-borne viruses,Zika virus(ZIKV)can cause microcephaly and various neurological symptoms in newborns.Previously,we found that ZIKV could infect hypothalamus,causing a decrease in growth hormone(GH)secretion,growth delay and deficits in learning and memory in suckling mice.Early administration of GH can improve the cognitive function of the mice.Therefore,in this study we further investigated the mechanism underlying the protective role of GH in ZIKV infection in suckling mice.Our results showed that GH could effectively reduce brain damage caused by ZIKV infection via reducing cell apoptosis and inflammatory response rather than inhibiting viral replication.Our results provide important evidences not only for understanding the mechanism underlying ZIKV-associated neurological symptoms but also for the treatment of ZIKV infection.

关 键 词：Zika virus(ZIKV) Growth hormone APOPTOSIS MICROCEPHALY 

分 类 号：R373.3[医药卫生—病原生物学]